SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		5 / 12 THR A  72
SER A  53
PHE A 137
LEU A 142
VAL A 235
 None
 1.36A 1q23D-4z48A:
undetectable
1q23E-4z48A:
undetectable		 1q23D-4z48A:
20.97
1q23E-4z48A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 ARG A 127
VAL A 103
TRP A 104
 None
 1.13A 1qw6A-4z48A:
undetectable		 1qw6A-4z48A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 ARG A 127
VAL A 103
TRP A 104
 None
 1.12A 1qwcA-4z48A:
undetectable		 1qwcA-4z48A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 7 TYR A  73
THR A 229
SER A  48
VAL A 255
 None
 1.15A 1tv8B-4z48A:
undetectable		 1tv8B-4z48A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 ARG A 127
VAL A 103
TRP A 104
 None
 1.09A 1vagA-4z48A:
undetectable		 1vagA-4z48A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 ARG A 127
VAL A 103
TRP A 104
 None
 1.05A 1zviA-4z48A:
undetectable		 1zviA-4z48A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 4 ILE A  88
ARG A 237
ILE A 147
THR A  99
 None
 1.29A 3ia4C-4z48A:
undetectable		 3ia4C-4z48A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.03A 3jx1A-4z48A:
undetectable
3jx1B-4z48A:
undetectable		 3jx1A-4z48A:
21.29
3jx1B-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 4 GLY A 108
GLU A 110
ASP A 112
ASP A 154
 None
 1.24A 3mb5A-4z48A:
undetectable		 3mb5A-4z48A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.04A 3nlyA-4z48A:
undetectable
3nlyB-4z48A:
undetectable		 3nlyA-4z48A:
21.29
3nlyB-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 LEU A 150
GLN A 191
TYR A 156
TYR A 158
 None
 1.14A 3po7A-4z48A:
undetectable		 3po7A-4z48A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.00A 3rqlA-4z48A:
undetectable
3rqlB-4z48A:
undetectable		 3rqlA-4z48A:
21.29
3rqlB-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		5 / 12 TYR A 172
LEU A 174
VAL A 193
ASP A 151
GLN A  44
 None
 1.30A 4c9wA-4z48A:
undetectable		 4c9wA-4z48A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.11A 4capA-4z48A:
undetectable
4capB-4z48A:
undetectable		 4capA-4z48A:
21.29
4capB-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.11A 4d32A-4z48A:
undetectable
4d32B-4z48A:
undetectable		 4d32A-4z48A:
21.29
4d32B-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 6 PHE A  70
PHE A  90
THR A 244
LEU A 142
 None
 0.93A 4ejgD-4z48A:
undetectable		 4ejgD-4z48A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		5 / 10 ILE A 147
PHE A 137
SER A  69
PRO A  93
ILE A  88
 None
 1.23A 4g8zX-4z48A:
undetectable		 4g8zX-4z48A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		5 / 12 ASP A  43
VAL A 153
ASN A 149
GLY A 108
ASP A  83
 None
 1.41A 4pevA-4z48A:
undetectable		 4pevA-4z48A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.07A 4v3yA-4z48A:
undetectable
4v3yB-4z48A:
undetectable		 4v3yA-4z48A:
21.29
4v3yB-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 VAL A 117
PHE A  90
ARG A  68
 None
None
IOD  A 301 (-4.5A)
 0.98A 4xr4B-4z48A:
undetectable		 4xr4B-4z48A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 ARG A 127
VAL A 103
TRP A 104
 None
 1.11A 5fvoA-4z48A:
undetectable		 5fvoA-4z48A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		4 / 8 SER A 105
ARG A 127
VAL A 103
TRP A 104
 None
 1.12A 5uo7A-4z48A:
undetectable
5uo7B-4z48A:
undetectable		 5uo7A-4z48A:
20.57
5uo7B-4z48A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4z48 UNCHARACTERIZED
PROTEIN
(Desulfovibrio
piger) 		3 / 3 TYR A  85
ASP A 113
ASP A  83
 None
 0.83A 5x6yA-4z48A:
undetectable		 5x6yA-4z48A:
16.67