SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 10 ALA A  63
GLU A 125
ARG A 198
ILE A 385
LEU A  14
 None
 1.30A 1a52A-4z4lA:
undetectable		 1a52A-4z4lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 10 ALA A  63
GLU A 125
ARG A 198
ILE A 385
LEU A  14
 None
 1.27A 1a52B-4z4lA:
undetectable		 1a52B-4z4lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 TRP A 355
VAL A 357
TRP A 307
 None
 1.21A 1c4dA-4z4lA:
undetectable
1c4dB-4z4lA:
undetectable		 1c4dA-4z4lA:
3.93
1c4dB-4z4lA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 GLN A 116
CYH A  51
VAL A  52
GLY A 119
 None
 1.06A 1ekjC-4z4lA:
undetectable
1ekjD-4z4lA:
undetectable		 1ekjC-4z4lA:
18.07
1ekjD-4z4lA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 CYH A  51
VAL A  52
GLY A 119
GLN A 116
 None
 1.02A 1ekjC-4z4lA:
undetectable
1ekjD-4z4lA:
undetectable		 1ekjC-4z4lA:
18.07
1ekjD-4z4lA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 ARG A 347
ILE A 340
TRP A 337
GLU A 338
 None
 1.42A 1nsiA-4z4lA:
undetectable
1nsiB-4z4lA:
undetectable		 1nsiA-4z4lA:
22.78
1nsiB-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 ARG A 347
ILE A 340
TRP A 337
GLU A 338
 None
 1.45A 1nsiC-4z4lA:
undetectable
1nsiD-4z4lA:
undetectable		 1nsiC-4z4lA:
22.78
1nsiD-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.45A 1nsiC-4z4lA:
undetectable
1nsiD-4z4lA:
undetectable		 1nsiC-4z4lA:
22.78
1nsiD-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 ALA A 332
VAL A 314
TRP A 337
 None
 0.84A 1tkqA-4z4lA:
undetectable		 1tkqA-4z4lA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 8 THR A 185
TRP A  98
SER A  55
ARG A  56
 None
 1.24A 1xr2B-4z4lA:
undetectable		 1xr2B-4z4lA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ASN A  86
SER A  55
LEU A  58
MET A 138
LEU A  96
 None
 1.40A 1ya3B-4z4lA:
undetectable		 1ya3B-4z4lA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.43A 2nsiA-4z4lA:
undetectable
2nsiB-4z4lA:
undetectable		 2nsiA-4z4lA:
22.78
2nsiB-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 ARG A 347
ILE A 340
TRP A 337
GLU A 338
 None
 1.42A 2nsiC-4z4lA:
undetectable
2nsiD-4z4lA:
undetectable		 2nsiC-4z4lA:
22.78
2nsiD-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.44A 2nsiC-4z4lA:
undetectable
2nsiD-4z4lA:
undetectable		 2nsiC-4z4lA:
22.78
2nsiD-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 PHE A  78
GLY A  31
GLY A  32
ASN A  54
 None
 0.95A 2qr2A-4z4lA:
undetectable
2qr2B-4z4lA:
undetectable		 2qr2A-4z4lA:
20.39
2qr2B-4z4lA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 TYR A 376
GLU A 312
ASN A 319
 None
 0.98A 2y7hC-4z4lA:
undetectable		 2y7hC-4z4lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 ARG A 347
ILE A 340
TRP A 337
GLU A 338
 None
 1.43A 3e7gA-4z4lA:
undetectable
3e7gB-4z4lA:
undetectable		 3e7gA-4z4lA:
22.09
3e7gB-4z4lA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.45A 3e7gA-4z4lA:
undetectable
3e7gB-4z4lA:
undetectable		 3e7gA-4z4lA:
22.09
3e7gB-4z4lA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 GLU A 158
HIS A 112
THR A 185
 None
 0.84A 3hkuA-4z4lA:
undetectable		 3hkuA-4z4lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.34A 4cx7C-4z4lA:
undetectable
4cx7D-4z4lA:
undetectable		 4cx7C-4z4lA:
22.78
4cx7D-4z4lA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 TYR A 376
HIS A 377
ARG A 380
 None
 0.96A 4e7bC-4z4lA:
undetectable		 4e7bC-4z4lA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.44A 4nosA-4z4lA:
undetectable
4nosB-4z4lA:
undetectable		 4nosA-4z4lA:
22.24
4nosB-4z4lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 ARG A 347
ILE A 340
TRP A 337
GLU A 338
 None
 1.47A 4nosC-4z4lA:
undetectable
4nosD-4z4lA:
undetectable		 4nosC-4z4lA:
22.24
4nosD-4z4lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 TRP A 337
GLU A 338
ARG A 347
ILE A 340
 None
 1.48A 4nosC-4z4lA:
undetectable
4nosD-4z4lA:
undetectable		 4nosC-4z4lA:
22.24
4nosD-4z4lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 5 ASP A 346
VAL A 345
TRP A 353
GLU A 352
 None
 1.42A 4qzuA-4z4lA:
0.0
4qzuD-4z4lA:
0.0		 4qzuA-4z4lA:
17.31
4qzuD-4z4lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 8 PHE A  81
SER A 130
ALA A 139
LEU A 123
 None
 1.02A 4rkuA-4z4lA:
undetectable
4rkuJ-4z4lA:
undetectable		 4rkuA-4z4lA:
18.84
4rkuJ-4z4lA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 VAL A 189
LEU A 190
ILE A 212
VAL A 271
LEU A 262
 None
 0.95A 4y8wA-4z4lA:
undetectable		 4y8wA-4z4lA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 VAL A 189
LEU A 190
ILE A 212
VAL A 271
LEU A 262
 None
 0.96A 4y8wB-4z4lA:
undetectable		 4y8wB-4z4lA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 PHE A 171
GLU A 158
GLU A 250
HIS A 377
GLY A 246
 None
 1.47A 4ydqB-4z4lA:
undetectable		 4ydqB-4z4lA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 LEU A  53
ASN A 378
LEU A  14
PHE A  60
ILE A  18
 None
 1.21A 5dv4A-4z4lA:
undetectable		 5dv4A-4z4lA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 VAL A 189
ALA A 117
VAL A 113
TYR A 114
 None
 1.03A 5i8fA-4z4lA:
undetectable		 5i8fA-4z4lA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ALA A 258
ILE A 293
TYR A 245
PHE A 317
PHE A 228
 None
 1.35A 5jlcA-4z4lA:
undetectable		 5jlcA-4z4lA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4z4l CELLOBIOSE
2-EPIMERASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 8 TRP A 236
HIS A 186
ARG A 152
GLU A 166
 None
 1.19A 6mn4A-4z4lA:
undetectable		 6mn4A-4z4lA:
18.67