SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z4m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		5 / 10 VAL A 150
TYR A  74
THR A 203
GLY A  40
ALA A  72
 CR2  A  66 ( 4.9A)
None
CR2  A  66 ( 3.6A)
None
None
 1.49A 2coiA-4z4mA:
undetectable
2coiB-4z4mA:
undetectable		 2coiA-4z4mA:
21.48
2coiB-4z4mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		3 / 3 ASN A 170
LEU A 141
HIS A 169
 None
 0.83A 2q6fB-4z4mA:
undetectable		 2q6fB-4z4mA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
 1.20A 3t3rB-4z4mA:
undetectable		 3t3rB-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
 1.22A 3t3rC-4z4mA:
undetectable		 3t3rC-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
 1.18A 3t3rD-4z4mA:
undetectable		 3t3rD-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.1A)
 0.93A 4o1zA-4z4mA:
undetectable		 4o1zA-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		4 / 8 TYR A  92
PHE A  84
VAL A 163
ILE A 123
 None
 0.94A 5hw8H-4z4mA:
undetectable		 5hw8H-4z4mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		5 / 12 LEU A 137
GLY A 138
GLN A 177
ILE A 171
ASP A 173
 None
 1.13A 6bxnB-4z4mA:
undetectable		 6bxnB-4z4mA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1
(Aequorea
victoria;
Homo
sapiens) 		4 / 8 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
 0.87A 6cduG-4z4mA:
undetectable
6cduH-4z4mA:
undetectable		 6cduG-4z4mA:
21.49
6cduH-4z4mA:
21.49