SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.47A 1n6cA-4z4pA:
13.9		 1n6cA-4z4pA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 10 GLY A5408
LEU A5409
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-3.1A)
None
None
 0.25A 2h21A-4z4pA:
7.3		 2h21A-4z4pA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5408
LEU A5409
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-3.1A)
None
None
 0.24A 2h21B-4z4pA:
7.0		 2h21B-4z4pA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5408
LEU A5409
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-3.1A)
None
None
 0.30A 2h21C-4z4pA:
7.5		 2h21C-4z4pA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.74A 2r3aA-4z4pA:
13.8		 2r3aA-4z4pA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		7 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.28A 3ooiA-4z4pA:
16.4		 3ooiA-4z4pA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5527
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.47A 3ooiA-4z4pA:
16.4		 3ooiA-4z4pA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.52A 3opeA-4z4pA:
16.8		 3opeA-4z4pA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.34A 3rq4A-4z4pA:
11.1		 3rq4A-4z4pA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.38A 3s8pA-4z4pA:
10.0		 3s8pA-4z4pA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.38A 4bupA-4z4pA:
9.7		 4bupA-4z4pA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.40A 4e47A-4z4pA:
13.8		 4e47A-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.17A 4e47A-4z4pA:
13.8		 4e47A-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.38A 4e47B-4z4pA:
12.0		 4e47B-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.14A 4e47B-4z4pA:
12.0		 4e47B-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.46A 4e47C-4z4pA:
13.7		 4e47C-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.18A 4e47C-4z4pA:
13.7		 4e47C-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.41A 4jdsA-4z4pA:
13.7		 4jdsA-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.08A 4jdsA-4z4pA:
13.7		 4jdsA-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.40A 4jdsB-4z4pA:
13.9		 4jdsB-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.13A 4jdsB-4z4pA:
13.9		 4jdsB-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.44A 4jdsC-4z4pA:
13.7		 4jdsC-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.16A 4jdsC-4z4pA:
13.7		 4jdsC-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.44A 4jlgA-4z4pA:
13.6		 4jlgA-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.25A 4jlgA-4z4pA:
13.6		 4jlgA-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.25A 4ynmA-4z4pA:
16.9		 4ynmA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
HIS A5539
ASN A5474
HIS A5475
CYH A5525
 SAH  A5602 (-3.6A)
None
SAH  A5602 (-3.1A)
None
ZN  A5601 ( 2.2A)
 0.96A 4ynmB-4z4pA:
17.4		 4ynmB-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.36A 4ynmB-4z4pA:
17.4		 4ynmB-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
HIS A5539
HIS A5475
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.95A 4ynpA-4z4pA:
16.7		 4ynpA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.34A 4ynpA-4z4pA:
16.7		 4ynpA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5527
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.00A 4ynpA-4z4pA:
16.7		 4ynpA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 10 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.10A 4ynpB-4z4pA:
17.4		 4ynpB-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 10 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.44A 4ynpB-4z4pA:
17.4		 4ynpB-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.08A 4ypaA-4z4pA:
16.6		 4ypaA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.45A 4ypaA-4z4pA:
16.6		 4ypaA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.25A 4ypaB-4z4pA:
16.6		 4ypaB-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.29A 4ypaC-4z4pA:
16.6		 4ypaC-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.07A 4ypaC-4z4pA:
16.6		 4ypaC-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.09A 4ypaD-4z4pA:
16.5		 4ypaD-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.35A 4ypaD-4z4pA:
16.5		 4ypaD-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.55A 4ypeA-4z4pA:
16.3		 4ypeA-4z4pA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.49A 4ypeB-4z4pA:
17.0		 4ypeB-4z4pA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.10A 4ypuA-4z4pA:
16.7		 4ypuA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
HIS A5539
ASN A5474
HIS A5475
CYH A5525
 SAH  A5602 (-3.6A)
None
SAH  A5602 (-3.1A)
None
ZN  A5601 ( 2.2A)
 0.92A 4ypuA-4z4pA:
16.7		 4ypuA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.44A 4ypuA-4z4pA:
16.7		 4ypuA-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
 0.33A 4ypuB-4z4pA:
17.0		 4ypuB-4z4pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
 0.42A 5ayfA-4z4pA:
13.4		 5ayfA-4z4pA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 ILE A5406
GLY A5408
GLY A5538
ASN A5474
TYR A5512
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 ( 4.2A)
SAH  A5602 (-3.1A)
None
 1.19A 5ayfA-4z4pA:
13.4		 5ayfA-4z4pA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.14A 5jhnA-4z4pA:
13.4		 5jhnA-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.43A 5jhnA-4z4pA:
13.4		 5jhnA-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.17A 5jhnB-4z4pA:
13.5		 5jhnB-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.45A 5jhnB-4z4pA:
13.5		 5jhnB-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 0.52A 5jinA-4z4pA:
13.4		 5jinA-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.48A 5jinB-4z4pA:
13.5		 5jinB-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.15A 5jiyA-4z4pA:
13.4		 5jiyA-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.47A 5jiyA-4z4pA:
13.4		 5jiyA-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.20A 5jiyB-4z4pA:
13.5		 5jiyB-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.48A 5jiyB-4z4pA:
13.5		 5jiyB-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 0.50A 5jj0A-4z4pA:
13.4		 5jj0A-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.25A 5jj0B-4z4pA:
13.5		 5jj0B-4z4pA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
TYR A5472
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
None
SAH  A5602 (-3.1A)
None
None
 0.37A 5kklB-4z4pA:
5.7		 5kklB-4z4pA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
TYR A5451
HIS A5475
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.42A 5lsuA-4z4pA:
16.5		 5lsuA-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		3 / 3 ASN A5474
TYR A5512
CYH A5525
 SAH  A5602 (-3.1A)
None
ZN  A5601 ( 2.2A)
 0.12A 5lsuB-4z4pA:
16.5		 5lsuB-4z4pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 10 TYR A5388
ILE A5494
ILE A5496
ILE A5424
ILE A5473
 None
 1.10A 5murE-4z4pA:
undetectable		 5murE-4z4pA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.40A 5t0kA-4z4pA:
13.6		 5t0kA-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.20A 5t0kB-4z4pA:
13.8		 5t0kB-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.49A 5t0mA-4z4pA:
13.7		 5t0mA-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.15A 5t0mB-4z4pA:
13.5		 5t0mB-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.49A 5t0mB-4z4pA:
13.5		 5t0mB-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 10 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
 0.57A 5tegB-4z4pA:
16.0
5tegE-4z4pA:
undetectable		 5tegB-4z4pA:
28.98
5tegE-4z4pA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 10 GLY A5408
TYR A5451
TYR A5472
ASN A5474
HIS A5475
TYR A5512
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
SAH  A5602 (-3.1A)
None
None
 0.54A 5tqrB-4z4pA:
12.2		 5tqrB-4z4pA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.46A 5ttfA-4z4pA:
13.4		 5ttfA-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.52A 5ttfB-4z4pA:
13.4		 5ttfB-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.34A 5ttfC-4z4pA:
13.4		 5ttfC-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.56A 5ttfD-4z4pA:
13.4		 5ttfD-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.40A 5ttfD-4z4pA:
13.4		 5ttfD-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.52A 5ttgA-4z4pA:
13.7		 5ttgA-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.44A 5ttgA-4z4pA:
13.7		 5ttgA-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.55A 5ttgB-4z4pA:
13.6		 5ttgB-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.43A 5ttgB-4z4pA:
13.6		 5ttgB-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.44A 5tuyA-4z4pA:
13.4		 5tuyA-4z4pA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.45A 5tuyB-4z4pA:
13.4		 5tuyB-4z4pA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.34A 5tuzA-4z4pA:
13.7		 5tuzA-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 None
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 1.14A 5tuzA-4z4pA:
13.7		 5tuzA-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.50A 5tuzB-4z4pA:
13.6		 5tuzB-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.46A 5tuzB-4z4pA:
13.6		 5tuzB-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.09A 5updA-4z4pA:
17.2		 5updA-4z4pA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		7 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.48A 5updA-4z4pA:
17.2		 5updA-4z4pA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.10A 5v21A-4z4pA:
16.1		 5v21A-4z4pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.39A 5v21A-4z4pA:
16.1		 5v21A-4z4pA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.15A 5v9iA-4z4pA:
13.4		 5v9iA-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.52A 5v9iA-4z4pA:
13.4		 5v9iA-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.55A 5v9iB-4z4pA:
13.5		 5v9iB-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.56A 5v9iC-4z4pA:
13.4		 5v9iC-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 11 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.43A 5v9iC-4z4pA:
13.4		 5v9iC-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 0.66A 5v9iD-4z4pA:
13.4		 5v9iD-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.36A 5v9iD-4z4pA:
13.4		 5v9iD-4z4pA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.48A 5v9jA-4z4pA:
13.7		 5v9jA-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.46A 5v9jA-4z4pA:
13.7		 5v9jA-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.52A 5v9jB-4z4pA:
13.6		 5v9jB-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.42A 5v9jB-4z4pA:
13.6		 5v9jB-4z4pA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.14A 5vscA-4z4pA:
13.5		 5vscA-4z4pA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.46A 5vscA-4z4pA:
13.5		 5vscA-4z4pA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.12A 5vscB-4z4pA:
13.2		 5vscB-4z4pA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.50A 5vscB-4z4pA:
13.2		 5vscB-4z4pA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.31A 5vsdA-4z4pA:
13.6		 5vsdA-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.53A 5vsdB-4z4pA:
13.6		 5vsdB-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.47A 5vsdB-4z4pA:
13.6		 5vsdB-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.15A 5vseA-4z4pA:
13.6		 5vseA-4z4pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.48A 5vseA-4z4pA:
13.6		 5vseA-4z4pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 1.14A 5vseB-4z4pA:
13.3		 5vseB-4z4pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.50A 5vseB-4z4pA:
13.3		 5vseB-4z4pA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.30A 5vsfA-4z4pA:
13.7		 5vsfA-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
 0.49A 5vsfB-4z4pA:
13.7		 5vsfB-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5525
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.48A 5vsfB-4z4pA:
13.7		 5vsfB-4z4pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.22A 6a5kA-4z4pA:
13.5		 6a5kA-4z4pA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		7 / 12 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.33A 6a5mA-4z4pA:
13.6		 6a5mA-4z4pA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.46A 6a5mA-4z4pA:
13.6		 6a5mA-4z4pA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5527
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.00A 6a5mA-4z4pA:
13.6		 6a5mA-4z4pA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		7 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.81A 6agoA-4z4pA:
15.6		 6agoA-4z4pA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5408
HIS A5475
CYH A5525
CYH A5527
GLY A5538
 SAH  A5602 (-3.6A)
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
SAH  A5602 ( 4.2A)
 0.95A 6bp4B-4z4pA:
13.7		 6bp4B-4z4pA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
TYR A5451
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.47A 6bp4B-4z4pA:
13.7		 6bp4B-4z4pA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 12 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5527
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 0.89A 6bp4B-4z4pA:
13.7		 6bp4B-4z4pA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		7 / 11 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.49A 6cenA-4z4pA:
16.7		 6cenA-4z4pA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		6 / 12 GLY A5408
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.30A 6ineA-4z4pA:
15.4		 6ineA-4z4pA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		4 / 7 GLY A5408
LEU A5409
TYR A5451
ASN A5474
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
 0.61A 6nm4A-4z4pA:
9.0		 6nm4A-4z4pA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D
(Homo
sapiens) 		5 / 9 ILE A5406
GLY A5408
LEU A5409
TYR A5451
ASN A5474
 SAH  A5602 (-4.1A)
SAH  A5602 (-3.6A)
SAH  A5602 (-4.1A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
 0.63A 6nm4B-4z4pA:
9.1		 6nm4B-4z4pA:
24.40