SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 10 LEU A 395
ALA A 121
VAL A 249
LEU A 245
PHE A 369
 None
 1.49A 1aqbA-4z5pA:
undetectable		 1aqbA-4z5pA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 LEU A 262
LEU A 253
VAL A 249
ILE A 136
LEU A 124
 None
 1.18A 1s19A-4z5pA:
undetectable		 1s19A-4z5pA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 4 VAL A 280
LEU A 372
ILE A 397
LEU A 374
 None
 1.03A 2byoA-4z5pA:
undetectable		 2byoA-4z5pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ALA A 236
THR A 240
CYH A 348
 HEM  A 401 (-3.9A)
HEM  A 401 (-4.5A)
HEM  A 401 (-2.4A)
 0.65A 3e4eA-4z5pA:
28.8		 3e4eA-4z5pA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ALA A 236
THR A 240
CYH A 348
 HEM  A 401 (-3.9A)
HEM  A 401 (-4.5A)
HEM  A 401 (-2.4A)
 0.57A 3e4eB-4z5pA:
25.1		 3e4eB-4z5pA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 10 ALA A 361
LEU A 140
ALA A 134
ILE A 397
LEU A 253
 None
 1.22A 3fl9A-4z5pA:
undetectable		 3fl9A-4z5pA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 VAL A 249
LEU A 123
LEU A 365
ALA A 141
LEU A 245
 None
 0.97A 3n8wA-4z5pA:
undetectable		 3n8wA-4z5pA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 VAL A 249
LEU A 123
LEU A 365
ALA A 141
LEU A 245
 None
 1.03A 3n8zA-4z5pA:
2.4		 3n8zA-4z5pA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 11 LEU A 252
GLY A 246
LEU A 276
ARG A 278
LEU A  19
 None
 1.11A 3ndvA-4z5pA:
undetectable
3ndvB-4z5pA:
undetectable		 3ndvA-4z5pA:
23.82
3ndvB-4z5pA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 11 GLY A 246
LEU A 276
ARG A 278
LEU A  19
LEU A 252
 None
 1.11A 3ndvC-4z5pA:
undetectable
3ndvD-4z5pA:
undetectable		 3ndvC-4z5pA:
23.82
3ndvD-4z5pA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 9 ARG A 263
LEU A 259
ALA A 251
GLY A 246
ILE A 136
 None
 1.18A 3spkA-4z5pA:
undetectable		 3spkA-4z5pA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 LEU A 372
ALA A 251
THR A 254
LEU A 395
 None
 0.90A 3t3zA-4z5pA:
28.4		 3t3zA-4z5pA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 LEU A 372
ALA A 251
THR A 254
LEU A 395
 None
 0.89A 3t3zB-4z5pA:
28.4		 3t3zB-4z5pA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 LEU A 372
ALA A 251
THR A 254
LEU A 395
 None
 0.90A 3t3zD-4z5pA:
28.3		 3t3zD-4z5pA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 LEU A 374
LEU A 372
GLY A 246
LEU A 245
PHE A 120
 None
 1.16A 3tbgA-4z5pA:
28.7		 3tbgA-4z5pA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 11 LEU A 252
THR A 254
LEU A 245
VAL A 137
PHE A 120
 None
 1.25A 3tbgA-4z5pA:
28.7		 3tbgA-4z5pA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 LEU A 153
ALA A 103
MET A 112
LEU A 353
PHE A 229
 None
None
None
HEM  A 401 ( 4.8A)
HEM  A 401 ( 4.9A)
 1.32A 4udaA-4z5pA:
undetectable		 4udaA-4z5pA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 TYR A 347
LEU A 339
ASP A  52
 None
 0.76A 5zv2B-4z5pA:
undetectable		 5zv2B-4z5pA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 VAL A 249
LEU A 262
LEU A 259
HIS A 255
 None
 0.98A 6e43A-4z5pA:
undetectable		 6e43A-4z5pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 VAL A 249
LEU A 262
LEU A 259
HIS A 255
 None
 1.02A 6e43B-4z5pA:
undetectable		 6e43B-4z5pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 VAL A 249
LEU A 262
LEU A 259
HIS A 255
 None
 1.00A 6e43C-4z5pA:
undetectable		 6e43C-4z5pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 VAL A 249
LEU A 262
LEU A 259
HIS A 255
 None
 0.99A 6e43D-4z5pA:
undetectable		 6e43D-4z5pA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ASN A 247
PRO A 392
GLN A 393
 None
 0.89A 6jnhA-4z5pA:
undetectable		 6jnhA-4z5pA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4z5p CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ASN A 247
PRO A 392
GLN A 393
 None
 0.93A 6jogA-4z5pA:
undetectable		 6jogA-4z5pA:
21.09