SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ASP A 269
ARG A 265
ILE A 335
 None
 0.77A 1a4gB-4z5qA:
undetectable		 1a4gB-4z5qA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 VAL A 313
VAL A 315
TRP A  50
 None
 0.99A 1bdwA-4z5qA:
undetectable
1bdwB-4z5qA:
undetectable		 1bdwA-4z5qA:
5.31
1bdwB-4z5qA:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 7 GLU A 361
LEU A 357
LEU A 157
GLY A 158
 HEM  A 401 ( 4.8A)
HEM  A 401 (-4.6A)
None
None
 0.91A 1mt1H-4z5qA:
undetectable
1mt1K-4z5qA:
undetectable		 1mt1H-4z5qA:
14.42
1mt1K-4z5qA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 6 GLU A 361
LEU A 357
LEU A 157
GLY A 158
 HEM  A 401 ( 4.8A)
HEM  A 401 (-4.6A)
None
None
 0.89A 1n13H-4z5qA:
undetectable
1n13K-4z5qA:
undetectable		 1n13H-4z5qA:
14.42
1n13K-4z5qA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 7 LEU A 357
LEU A 157
GLY A 158
GLU A 361
 HEM  A 401 (-4.6A)
None
None
HEM  A 401 ( 4.8A)
 0.91A 1n13G-4z5qA:
undetectable
1n13J-4z5qA:
undetectable		 1n13G-4z5qA:
8.17
1n13J-4z5qA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 7 LEU A 238
PHE A 242
GLY A 241
ILE A 113
 None
None
HEM  A 401 (-3.2A)
None
 1.07A 2bdmA-4z5qA:
23.9		 2bdmA-4z5qA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		4 / 7 GLY A 241
GLY A 240
VAL A 152
LEU A 357
 HEM  A 401 (-3.2A)
P33  A 407 ( 3.4A)
None
HEM  A 401 (-4.6A)
 0.78A 2oa1B-4z5qA:
undetectable		 2oa1B-4z5qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ASP A 220
THR A 109
PRO A 110
 None
 0.63A 2q64B-4z5qA:
undetectable		 2q64B-4z5qA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 11 MET A 373
LEU A 369
LEU A 366
MET A 131
GLY A 126
 None
 1.36A 3hm1B-4z5qA:
2.3		 3hm1B-4z5qA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 11 VAL A 360
PHE A 345
GLY A 241
GLY A 240
ILE A 237
 None
HEM  A 401 (-4.6A)
HEM  A 401 (-3.2A)
P33  A 407 ( 3.4A)
HEM  A 401 (-4.5A)
 0.90A 3owxA-4z5qA:
undetectable
3owxB-4z5qA:
undetectable		 3owxA-4z5qA:
21.21
3owxB-4z5qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 PHE A 345
CYH A 352
GLU A 361
PRO A 149
VAL A 344
 HEM  A 401 (-4.6A)
HEM  A 401 (-2.2A)
HEM  A 401 ( 4.8A)
None
HEM  A 401 (-4.6A)
 1.44A 3rfaA-4z5qA:
undetectable		 3rfaA-4z5qA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 PHE A 345
CYH A 352
GLU A 361
PRO A 149
VAL A 344
 HEM  A 401 (-4.6A)
HEM  A 401 (-2.2A)
HEM  A 401 ( 4.8A)
None
HEM  A 401 (-4.6A)
 1.47A 3rfaB-4z5qA:
undetectable		 3rfaB-4z5qA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ASP A 220
THR A 109
PRO A 110
 None
 0.67A 3tkgD-4z5qA:
undetectable		 3tkgD-4z5qA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 LEU A 157
ILE A 216
ILE A 237
CYH A 234
ALA A 107
 None
None
HEM  A 401 (-4.5A)
None
None
 1.26A 3uj7A-4z5qA:
undetectable		 3uj7A-4z5qA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 GLY A 241
GLY A 240
ILE A 237
VAL A 360
PHE A 345
 HEM  A 401 (-3.2A)
P33  A 407 ( 3.4A)
HEM  A 401 (-4.5A)
None
HEM  A 401 (-4.6A)
 0.95A 4fglA-4z5qA:
undetectable
4fglB-4z5qA:
undetectable		 4fglA-4z5qA:
21.21
4fglB-4z5qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		3 / 3 ASP A  37
GLY A 303
ASP A  57
 None
 0.62A 4xdtA-4z5qA:
undetectable		 4xdtA-4z5qA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 11 VAL A 360
PHE A 345
GLY A 241
GLY A 240
ILE A 237
 None
HEM  A 401 (-4.6A)
HEM  A 401 (-3.2A)
P33  A 407 ( 3.4A)
HEM  A 401 (-4.5A)
 0.90A 4zvmA-4z5qA:
undetectable
4zvmB-4z5qA:
undetectable		 4zvmA-4z5qA:
21.03
4zvmB-4z5qA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 ALA A 276
LEU A 280
ILE A 239
LEU A 357
PHE A 345
 None
None
P33  A 407 ( 4.5A)
HEM  A 401 (-4.6A)
HEM  A 401 (-4.6A)
 1.15A 5eshA-4z5qA:
25.2		 5eshA-4z5qA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		5 / 12 GLU A 371
LYS A 367
GLY A 121
LEU A 127
ALA A 147
 None
 1.26A 5kbwA-4z5qA:
undetectable		 5kbwA-4z5qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4z5q CYTOCHROME P450
HYDROXYLASE
(Streptomyces
atroolivaceus) 		6 / 11 LEU A 127
GLU A 371
GLY A 372
SER A 143
GLU A 364
ALA A 124
 None
 1.44A 5o96G-4z5qA:
undetectable		 5o96G-4z5qA:
21.57