SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
 1.32A 1dz8A-4z5sA:
undetectable		 1dz8A-4z5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
 1.34A 1dz8B-4z5sA:
undetectable		 1dz8B-4z5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
 1.35A 1dz9B-4z5sA:
undetectable		 1dz9B-4z5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 9 TYR A  17
LEU A  74
VAL A  76
VAL A  28
ILE A  24
 None
 1.26A 1gebA-4z5sA:
undetectable		 1gebA-4z5sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.47A 1kiaA-4z5sA:
undetectable		 1kiaA-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.46A 1kiaB-4z5sA:
undetectable		 1kiaB-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.45A 1kiaC-4z5sA:
undetectable		 1kiaC-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.45A 1kiaD-4z5sA:
undetectable		 1kiaD-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.47A 1nbhA-4z5sA:
undetectable		 1nbhA-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.45A 1nbhB-4z5sA:
undetectable		 1nbhB-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.47A 1nbhC-4z5sA:
undetectable		 1nbhC-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR A  17
TYR A  12
TYR A  21
TYR A 125
 None
 1.45A 1nbhD-4z5sA:
undetectable		 1nbhD-4z5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		6 / 9 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
ILE A  24
 None
 1.29A 2a1oB-4z5sA:
undetectable		 2a1oB-4z5sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 TYR A  17
LEU A  74
VAL A  76
GLY A  71
VAL A  28
 None
 1.29A 2cp4A-4z5sA:
undetectable		 2cp4A-4z5sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 7 GLU A 194
LYS A 195
LEU A 198
ASN A 182
LEU A 181
 None
 1.15A 4wg0B-4z5sA:
undetectable
4wg0C-4z5sA:
undetectable		 4wg0B-4z5sA:
9.03
4wg0C-4z5sA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4z5s ALDEHYDE
DECARBONYLASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 109
PHE A 117
ALA A 118
ILE A  27
ALA A  83
 None
 1.09A 5vceA-4z5sA:
undetectable		 5vceA-4z5sA:
18.14