SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z5y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 ASP A  59
ASP A 220
HIS A 269
THR A 273
GLY A  12
 None
None
CU  A 402 (-3.6A)
None
None
 1.46A 1ia0B-4z5yA:
undetectable		 1ia0B-4z5yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 6 SER A  57
ASN A  55
LEU A  87
ASP A  88
 None
 1.06A 1mxdA-4z5yA:
undetectable		 1mxdA-4z5yA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 8 SER A  57
ASN A  55
LEU A  87
ASP A  88
 None
 1.04A 1mxgA-4z5yA:
undetectable		 1mxgA-4z5yA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 4 THR A 273
GLY A 221
ASP A 220
ALA A 246
 None
 1.16A 1sg9A-4z5yA:
undetectable		 1sg9A-4z5yA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 ASP A  59
ASP A 220
HIS A 269
THR A 273
GLY A  12
 None
None
CU  A 402 (-3.6A)
None
None
 1.46A 1tubB-4z5yA:
undetectable		 1tubB-4z5yA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 6 PRO A 198
GLY A 199
LEU A 161
ASN A 180
 None
 1.02A 3zqtA-4z5yA:
undetectable		 3zqtA-4z5yA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 5 HIS A 307
LEU A 257
LEU A 208
ASP A 258
 None
 1.25A 4aqlA-4z5yA:
undetectable		 4aqlA-4z5yA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 GLU A 228
LEU A 267
GLY A 221
VAL A 294
ALA A 295
 None
 1.06A 4fqsA-4z5yA:
undetectable		 4fqsA-4z5yA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 GLU A 228
LEU A 267
GLY A 221
VAL A 294
ALA A 295
 None
 1.06A 4fqsB-4z5yA:
undetectable		 4fqsB-4z5yA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 ASP A  92
GLY A  13
SER A  41
GLY A   7
THR A 222
 None
 1.09A 4mm8A-4z5yA:
undetectable		 4mm8A-4z5yA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 GLY A  12
SER A  41
GLY A   7
ASP A 220
THR A 222
 None
 1.12A 4mm8A-4z5yA:
undetectable		 4mm8A-4z5yA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		3 / 3 MET A 113
ASP A 174
PHE A 173
 None
 1.06A 4xeyB-4z5yA:
undetectable		 4xeyB-4z5yA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 5 TYR A   2
ILE A   3
PRO A 152
THR A 190
 None
None
None
NA  A 403 (-2.9A)
 1.18A 4ze1A-4z5yA:
undetectable		 4ze1A-4z5yA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 6 LEU A  97
TRP A  51
GLN A   4
MET A  70
 None
 1.44A 5h8tA-4z5yA:
0.0		 5h8tA-4z5yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		3 / 3 GLN A  63
THR A  38
ASP A 297
 None
 0.89A 5k9dA-4z5yA:
undetectable		 5k9dA-4z5yA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 5 LEU A  44
TYR A   2
LYS A   0
LEU A 154
 None
None
NA  A 403 (-3.8A)
None
 1.47A 5ki6A-4z5yA:
undetectable		 5ki6A-4z5yA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		3 / 3 HIS A 306
ASP A 215
HIS A 307
 None
 0.90A 5n1tW-4z5yA:
undetectable		 5n1tW-4z5yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 4 THR A 111
ASP A 112
ARG A 139
LEU A 142
 None
 1.40A 5tdmA-4z5yA:
undetectable		 5tdmA-4z5yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 12 PHE A 159
LEU A 200
VAL A 256
THR A 157
GLU A 205
 None
 1.20A 5v1tA-4z5yA:
undetectable		 5v1tA-4z5yA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		5 / 11 THR A  94
ASN A  55
THR A 119
THR A 111
ILE A 140
 None
 1.43A 6hcoA-4z5yA:
undetectable
6hcoB-4z5yA:
undetectable		 6hcoA-4z5yA:
18.50
6hcoB-4z5yA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 5 LEU A 217
ILE A 140
MET A 210
GLY A 213
 None
 0.97A 6hd6A-4z5yA:
undetectable		 6hd6A-4z5yA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4z5y COENZYME PQQ
SYNTHESIS PROTEIN B
(Pseudomonas
putida) 		4 / 7 ILE A 270
TRP A 224
GLU A 283
VAL A 294
 None
 0.95A 6j20A-4z5yA:
undetectable		 6j20A-4z5yA:
21.60