SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 9 LEU A 199
ILE A 200
VAL A 234
GLY A 233
ALA A 229
 None
 1.29A 1e7aA-4z6gA:
undetectable		 1e7aA-4z6gA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 12 PHE A 112
LEU A 110
ALA A 109
LEU A 139
LEU A  82
 None
 1.22A 1og5A-4z6gA:
undetectable		 1og5A-4z6gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		4 / 8 SER A 187
SER A 247
SER A 188
ASN A 185
 None
 1.14A 2cmlB-4z6gA:
undetectable		 2cmlB-4z6gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 12 ILE A 123
ILE A 128
GLY A  76
LEU A  82
LEU A 113
 None
 1.00A 3em0B-4z6gA:
undetectable		 3em0B-4z6gA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 12 PHE A 186
LEU A 167
GLY A 193
MET A 195
LEU A 199
 None
 1.28A 4kykA-4z6gA:
undetectable
4kykB-4z6gA:
undetectable		 4kykA-4z6gA:
18.84
4kykB-4z6gA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 11 LEU A 199
ALA A 198
VAL A 208
ASP A 206
ASP A 280
 None
 1.15A 4uuuA-4z6gA:
undetectable
4uuuB-4z6gA:
undetectable		 4uuuA-4z6gA:
17.09
4uuuB-4z6gA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		3 / 3 MET A 161
GLU A 165
LEU A 169
 None
 0.50A 4v2oB-4z6gA:
undetectable		 4v2oB-4z6gA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		4 / 8 ARG A  45
VAL A  46
ASP A 239
ASP A 242
 None
 1.09A 4xqgA-4z6gA:
undetectable		 4xqgA-4z6gA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		4 / 8 ARG A  45
VAL A  46
ASP A 239
ASP A 242
 None
 1.09A 4xqgB-4z6gA:
undetectable		 4xqgB-4z6gA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		4 / 8 GLY A 138
THR A 142
LEU A 135
ASN A 122
 None
 0.86A 5hwaA-4z6gA:
undetectable		 5hwaA-4z6gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		3 / 3 GLU A  94
HIS A 101
ARG A 102
 None
 0.93A 5uunA-4z6gA:
undetectable		 5uunA-4z6gA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 10 ILE A 140
ILE A 144
LEU A 145
ILE A 128
ASN A 132
 None
 1.29A 5vkqA-4z6gA:
undetectable
5vkqD-4z6gA:
undetectable		 5vkqA-4z6gA:
12.05
5vkqD-4z6gA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 10 ILE A 128
ASN A 132
ILE A 140
ILE A 144
LEU A 145
 None
 1.30A 5vkqA-4z6gA:
undetectable
5vkqB-4z6gA:
undetectable		 5vkqA-4z6gA:
12.05
5vkqB-4z6gA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		5 / 10 ILE A 128
ASN A 132
ILE A 140
ILE A 144
LEU A 145
 None
 1.29A 5vkqC-4z6gA:
undetectable
5vkqD-4z6gA:
undetectable		 5vkqC-4z6gA:
12.05
5vkqD-4z6gA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		4 / 5 TYR A 323
ARG A 382
MET A 379
LEU A 375
 None
 1.32A 5x19J-4z6gA:
undetectable		 5x19J-4z6gA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		4 / 5 TYR A 323
ARG A 382
MET A 379
LEU A 375
 None
 1.33A 5x1bJ-4z6gA:
undetectable		 5x1bJ-4z6gA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens) 		3 / 3 ARG A 202
HIS A 201
ARG A 356
 None
 0.80A 6dwdD-4z6gA:
undetectable		 6dwdD-4z6gA:
20.65