SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 PRO A  55
PHE A  57
PRO A  59
ILE A 316
SER A  12
 None
 1.10A 1fm4A-4z6kA:
undetectable		 1fm4A-4z6kA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		4 / 6 ALA A 310
ASP A 335
GLU A 311
ARG A 322
 None
 1.45A 2ouzA-4z6kA:
undetectable		 2ouzA-4z6kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 LEU A 251
LEU A 257
ILE A 228
VAL A 239
VAL A 194
 None
 1.17A 2po7A-4z6kA:
3.8		 2po7A-4z6kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 VAL A 181
ILE A 173
GLY A 174
GLY A 175
VAL A 304
 None
 1.01A 2r5pA-4z6kA:
undetectable		 2r5pA-4z6kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 VAL A 181
ILE A 173
GLY A 174
GLY A 175
VAL A 304
 None
 1.01A 2r5pC-4z6kA:
undetectable		 2r5pC-4z6kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 ILE A 328
ALA A   3
LEU A  13
ILE A 319
MET A 323
 None
 1.33A 2xkwB-4z6kA:
undetectable		 2xkwB-4z6kA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 9 ALA A 234
GLY A 230
LEU A 257
LEU A 248
ALA A 247
 None
 0.96A 2z0yA-4z6kA:
2.4		 2z0yA-4z6kA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		6 / 9 ALA A 234
VAL A 169
GLY A 230
LEU A 257
LEU A 248
ALA A 247
 None
 1.23A 2z0yB-4z6kA:
2.3		 2z0yB-4z6kA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 LEU A 251
LEU A 257
ILE A 228
VAL A 239
VAL A 194
 None
 1.27A 3aqiB-4z6kA:
undetectable		 3aqiB-4z6kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 GLU A  62
VAL A  37
CYH A  38
 ZN  A 401 (-3.6A)
None
ZN  A 401 (-2.2A)
 1.06A 3fbxA-4z6kA:
undetectable		 3fbxA-4z6kA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 GLY A  84
GLU A  62
ALA A 149
ASP A  41
ARG A 331
 None
ZN  A 401 (-3.6A)
None
None
ZN  A 401 (-4.0A)
 1.41A 3jzjA-4z6kA:
undetectable		 3jzjA-4z6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 ALA A 144
GLY A  63
HIS A  61
MET A  32
ASP A 139
 None
None
ZN  A 401 (-3.3A)
None
None
 1.31A 3pfgA-4z6kA:
8.3		 3pfgA-4z6kA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 LEU A 251
LEU A 257
ILE A 228
VAL A 239
VAL A 194
 None
 1.25A 3w1wB-4z6kA:
4.2		 3w1wB-4z6kA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		4 / 7 GLU A  16
HIS A   7
PRO A  56
VAL A  18
 None
 1.03A 4hvrA-4z6kA:
undetectable		 4hvrA-4z6kA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 HIS A  76
GLY A 132
ILE A 133
 None
 0.60A 4k50A-4z6kA:
undetectable		 4k50A-4z6kA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 HIS A  76
GLY A 132
ILE A 133
 None
 0.63A 4k50I-4z6kA:
undetectable		 4k50I-4z6kA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.95A 4k8cA-4z6kA:
5.6		 4k8cA-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.95A 4kahA-4z6kA:
5.8		 4kahA-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.95A 4kahB-4z6kA:
5.2		 4kahB-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.96A 4kanA-4z6kA:
5.8		 4kanA-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.95A 4kanB-4z6kA:
5.2		 4kanB-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.94A 4kbeA-4z6kA:
5.8		 4kbeA-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.93A 4kbeB-4z6kA:
5.8		 4kbeB-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.96A 4lbgA-4z6kA:
5.2		 4lbgA-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 SER A 295
TYR A 183
PRO A 135
 None
 0.96A 4lbgB-4z6kA:
5.2		 4lbgB-4z6kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 ILE A 133
ASP A 297
ARG A  82
 None
 0.81A 4pstA-4z6kA:
undetectable		 4pstA-4z6kA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 THR A 152
GLY A 261
ASN A 260
LEU A  42
ALA A  44
 None
 1.02A 4uckB-4z6kA:
undetectable		 4uckB-4z6kA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 ALA A 192
TRP A 167
VAL A 168
 None
 0.40A 4w9nC-4z6kA:
27.8		 4w9nC-4z6kA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		4 / 7 MET A 323
HIS A  61
CYH A 148
GLY A  36
 None
ZN  A 401 (-3.3A)
ZN  A 401 (-2.3A)
None
 0.94A 5a5zC-4z6kA:
undetectable		 5a5zC-4z6kA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		4 / 6 LEU A 257
LEU A 248
SER A 249
VAL A 194
 None
 1.21A 5a6iA-4z6kA:
undetectable		 5a6iA-4z6kA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 LEU A 262
LEU A 157
THR A 237
GLY A 177
ILE A 170
 None
 0.92A 5d4uC-4z6kA:
7.0		 5d4uC-4z6kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 12 LEU A 262
LEU A 157
THR A 237
GLY A 177
ILE A 170
 None
 0.93A 5d4uD-4z6kA:
6.9		 5d4uD-4z6kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		5 / 9 ILE A 334
TYR A 336
LEU A 313
ILE A  58
GLY A 118
 None
 1.46A 5ifuB-4z6kA:
2.1		 5ifuB-4z6kA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		3 / 3 GLY A  93
CYH A  98
CYH A  95
 ZN  A 402 ( 4.7A)
ZN  A 402 (-2.3A)
ZN  A 402 (-2.3A)
 0.96A 5inzB-4z6kA:
undetectable		 5inzB-4z6kA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4z6k ALCOHOL
DEHYDROGENASE
(Moraxella
sp.
TAE123) 		4 / 6 THR A 274
ASP A 273
LEU A 248
ASP A 245
 None
 0.86A 5tdzA-4z6kA:
2.5		 5tdzA-4z6kA:
24.20