SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4z6y TBC1 DOMAIN FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 4 LYS B 139
LEU B 135
ALA B 105
LEU B 109
 None
 1.19A 1f86B-4z6yB:
undetectable		 1f86B-4z6yB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4z6y TBC1 DOMAIN FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 10 GLU B 241
LEU B 181
MET B 251
HIS B 191
LEU B 192
 None
 1.47A 3erdB-4z6yB:
undetectable		 3erdB-4z6yB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4z6y TBC1 DOMAIN FAMILY
MEMBER 7
(Homo
sapiens) 		4 / 5 TYR B 166
GLN B 161
ILE B  66
LEU B  64
 None
 1.10A 3ls4L-4z6yB:
undetectable		 3ls4L-4z6yB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4z6y TBC1 DOMAIN FAMILY
MEMBER 7
(Homo
sapiens) 		5 / 12 ILE B 154
LEU B 215
PHE B 158
VAL B 238
LEU B 235
 None
 1.03A 3w67B-4z6yB:
undetectable		 3w67B-4z6yB:
22.15