SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z79'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		4 / 5 ASP A 373
LEU A 405
GLY A 401
ARG A 409
 None
None
None
CL  A 507 (-4.1A)
 1.22A 2j2pA-4z79A:
undetectable
2j2pB-4z79A:
undetectable		 2j2pA-4z79A:
19.82
2j2pB-4z79A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		4 / 4 ASP A 373
LEU A 405
GLY A 401
ARG A 409
 None
None
None
CL  A 507 (-4.1A)
 1.25A 2j2pD-4z79A:
undetectable
2j2pE-4z79A:
undetectable		 2j2pD-4z79A:
19.82
2j2pE-4z79A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 11 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
None
None
None
GOL  A 504 (-3.5A)
 1.15A 2qd3A-4z79A:
undetectable		 2qd3A-4z79A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 ILE A 399
ASN A 336
ILE A 379
ALA A 380
LEU A 420
 None
GOL  A 505 (-4.2A)
None
GOL  A 502 (-3.6A)
None
 0.98A 3a50A-4z79A:
undetectable		 3a50A-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.79A 3a50A-4z79A:
undetectable		 3a50A-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 11 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.79A 3a50C-4z79A:
undetectable		 3a50C-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 ILE A 399
ASN A 336
ILE A 379
ALA A 380
LEU A 420
 None
GOL  A 505 (-4.2A)
None
GOL  A 502 (-3.6A)
None
 0.97A 3a50D-4z79A:
undetectable		 3a50D-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.87A 3a50E-4z79A:
undetectable		 3a50E-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 11 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.84A 3a51A-4z79A:
undetectable		 3a51A-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.81A 3a51C-4z79A:
undetectable		 3a51C-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.84A 3a51D-4z79A:
undetectable		 3a51D-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 ILE A 399
ASN A 336
ILE A 379
ALA A 380
LEU A 420
 None
GOL  A 505 (-4.2A)
None
GOL  A 502 (-3.6A)
None
 1.06A 3a51E-4z79A:
undetectable		 3a51E-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.88A 3a51E-4z79A:
undetectable		 3a51E-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		6 / 10 LEU A 417
ALA A 410
ILE A 381
GLY A 403
ILE A 404
LEU A 383
 None
None
GOL  A 502 ( 4.3A)
None
None
None
 1.35A 3ogpA-4z79A:
undetectable		 3ogpA-4z79A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		6 / 10 LEU A 417
ALA A 410
ILE A 381
GLY A 403
ILE A 404
LEU A 383
 None
None
GOL  A 502 ( 4.3A)
None
None
None
 1.38A 3ogqA-4z79A:
undetectable		 3ogqA-4z79A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		3 / 3 ASN A 386
ALA A 385
LYS A 387
 None
None
NA  A 509 (-4.3A)
 0.95A 3runA-4z79A:
undetectable		 3runA-4z79A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 ILE A 379
ILE A 399
ALA A 371
THR A 369
VAL A 337
 None
None
None
None
GOL  A 501 ( 4.8A)
 1.22A 3s79A-4z79A:
undetectable		 3s79A-4z79A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
None
None
None
GOL  A 504 (-3.5A)
 1.15A 4f4dA-4z79A:
undetectable		 4f4dA-4z79A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
None
None
None
GOL  A 504 (-3.5A)
 1.10A 4f4dB-4z79A:
undetectable		 4f4dB-4z79A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 10 ILE A 379
ILE A 399
ALA A 371
THR A 369
VAL A 337
 None
None
None
None
GOL  A 501 ( 4.8A)
 1.22A 4kq8A-4z79A:
undetectable		 4kq8A-4z79A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 12 ILE A 379
ILE A 399
ALA A 371
THR A 369
VAL A 337
 None
None
None
None
GOL  A 501 ( 4.8A)
 1.21A 5jkvA-4z79A:
undetectable		 5jkvA-4z79A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)
(Homo
sapiens) 		5 / 11 ILE A 379
ILE A 399
THR A 369
VAL A 337
VAL A 335
 None
None
None
GOL  A 501 ( 4.8A)
GOL  A 501 (-3.9A)
 1.07A 5jkwA-4z79A:
undetectable		 5jkwA-4z79A:
18.34