SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		4 / 7 TYR A 381
PHE A 374
PHE A 370
PHE A 392
 None
 1.22A 1e71M-4z7eA:
undetectable		 1e71M-4z7eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		4 / 7 TYR A 381
PHE A 374
PHE A 370
PHE A 392
 None
 1.20A 1e72M-4z7eA:
undetectable		 1e72M-4z7eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU A 263
GLU A 458
LEU A 459
ILE A 236
LEU A 453
 None
 1.06A 1wopA-4z7eA:
undetectable		 1wopA-4z7eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU A 263
GLU A 458
LEU A 459
ILE A 236
MET A 448
 None
 1.23A 1wopA-4z7eA:
undetectable		 1wopA-4z7eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 9 PHE A 374
PHE A 392
VAL A 366
PHE A 370
LEU A 390
 None
 1.37A 1wrkA-4z7eA:
undetectable
1wrkB-4z7eA:
undetectable		 1wrkA-4z7eA:
14.48
1wrkB-4z7eA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 414
ALA A 342
ARG A 403
ASN A 413
PHE A 392
 None
 1.22A 2ejtA-4z7eA:
undetectable		 2ejtA-4z7eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 421
ASP A 472
ASP A 416
 1PE  A 604 (-3.2A)
None
None
 0.72A 2igtA-4z7eA:
undetectable		 2igtA-4z7eA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		4 / 7 PHE A 292
THR A 420
ILE A 502
GLY A 444
 PPI  A 601 (-3.2A)
None
None
PPI  A 601 ( 3.9A)
 0.91A 2v0mB-4z7eA:
undetectable		 2v0mB-4z7eA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ASP A 416
LEU A 414
PHE A 392
TYR A 381
ILE A 384
 None
 1.08A 3o94A-4z7eA:
undetectable		 3o94A-4z7eA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ASP A 416
LEU A 414
PHE A 392
TYR A 381
ILE A 384
 None
 1.15A 3o94B-4z7eA:
undetectable		 3o94B-4z7eA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ASP A 416
LEU A 414
PHE A 392
TYR A 381
ILE A 384
 None
 1.13A 3o94C-4z7eA:
undetectable		 3o94C-4z7eA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ASP A 416
LEU A 414
PHE A 392
TYR A 381
ILE A 384
 None
 1.12A 3o94D-4z7eA:
undetectable		 3o94D-4z7eA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		4 / 6 GLU A 247
ILE A 250
ASN A 251
GLU A 235
 None
 0.92A 4ejwB-4z7eA:
undetectable		 4ejwB-4z7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 12 PHE A 392
ILE A 384
LEU A 359
LEU A 432
VAL A 343
 None
 1.19A 5im2A-4z7eA:
6.7		 5im2A-4z7eA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		5 / 9 LEU A 432
LEU A 359
ILE A 407
LEU A 424
ALA A 368
 None
 1.23A 5og9A-4z7eA:
undetectable		 5og9A-4z7eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4z7e LMO1422 PROTEIN
(Listeria
monocytogenes) 		4 / 4 LEU A 353
LEU A 432
SER A 344
ALA A 342
 None
 1.08A 5uunA-4z7eA:
undetectable		 5uunA-4z7eA:
20.06