SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		5 / 12 GLY A  92
PHE A  41
GLY A  88
ALA A  56
PHE A  39
 None
 1.14A 2dpmA-4z7fA:
undetectable		 2dpmA-4z7fA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		3 / 3 LYS A  36
ARG A  26
VAL A  22
 FOL  A 201 (-2.9A)
None
None
 0.90A 4x3uA-4z7fA:
undetectable
4x3uB-4z7fA:
undetectable		 4x3uA-4z7fA:
16.86
4x3uB-4z7fA:
16.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_A_FOLA201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		12 / 12 LEU A  35
LYS A  36
SER A  38
ASP A  64
MET A  68
ALA A  74
TYR A  76
PHE A  80
THR A  81
ASN A 117
ARG A 142
LYS A 145
 FOL  A 201 (-4.4A)
FOL  A 201 (-2.9A)
FOL  A 201 (-3.5A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.8A)
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
 0.03A 4z7fA-4z7fA:
33.7		 4z7fA-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		11 / 12 ASP A  64
MET A  68
ALA A  74
TYR A  76
PHE A  77
PHE A  80
THR A  81
ASN A 117
THR A 121
ARG A 142
LYS A 145
 FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.8A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
 0.60A 4z7fB-4z7fA:
26.7		 4z7fB-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		8 / 12 SER A  38
ALA A  74
PHE A  77
PHE A  80
THR A  81
ASN A 117
THR A 121
LYS A 145
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.6A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
FOL  A 201 (-3.7A)
 0.86A 4z7fC-4z7fA:
27.7		 4z7fC-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		9 / 12 SER A  38
ALA A  74
PHE A  77
PHE A  80
THR A  81
THR A 121
LEU A 125
ARG A 142
LYS A 145
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.6A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-2.6A)
None
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
 0.59A 4z7fC-4z7fA:
27.7		 4z7fC-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_D_FOLD201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		6 / 11 LYS A  36
SER A  38
ASP A  64
MET A  68
ALA A  74
LYS A 145
 FOL  A 201 (-2.9A)
FOL  A 201 (-3.5A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.7A)
 1.32A 4z7fD-4z7fA:
27.2		 4z7fD-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_D_FOLD201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		8 / 11 SER A  38
ASP A  64
MET A  68
ALA A  74
ASN A  83
ASN A 117
THR A 121
LYS A 145
 FOL  A 201 (-3.5A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
None
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
FOL  A 201 (-3.7A)
 0.97A 4z7fD-4z7fA:
27.2		 4z7fD-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		6 / 9 MET A  68
ALA A  74
PHE A  80
THR A  81
ASN A 117
THR A 121
 FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
 0.86A 4z7fE-4z7fA:
21.2		 4z7fE-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		6 / 9 SER A  38
MET A  68
ALA A  74
PHE A  80
ASN A 117
THR A 121
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.6A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
 1.08A 4z7fE-4z7fA:
21.2		 4z7fE-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z7F_E_FOLE201_0
(FOLATE ECF
TRANSPORTER)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		6 / 9 SER A  38
MET A  68
TYR A  76
PHE A  80
ASN A 117
THR A 121
 FOL  A 201 (-3.5A)
FOL  A 201 (-3.2A)
FOL  A 201 (-3.8A)
FOL  A 201 (-3.9A)
FOL  A 201 (-3.7A)
FOL  A 201 (-2.6A)
 1.20A 4z7fE-4z7fA:
21.2		 4z7fE-4z7fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		5 / 12 LEU A  35
ASP A  64
PHE A  80
THR A  81
LYS A 145
 FOL  A 201 (-4.4A)
FOL  A 201 (-2.8A)
FOL  A 201 (-3.9A)
FOL  A 201 (-4.5A)
FOL  A 201 (-3.7A)
 0.80A 5d0yB-4z7fA:
22.9		 5d0yB-4z7fA:
33.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		4 / 7 VAL A 112
THR A 113
VAL A 154
THR A 157
 None
 1.05A 5e4dA-4z7fA:
undetectable
5e4dB-4z7fA:
undetectable		 5e4dA-4z7fA:
23.11
5e4dB-4z7fA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		4 / 7 VAL A 154
THR A 157
VAL A 112
THR A 113
 None
 1.03A 5e4dA-4z7fA:
undetectable
5e4dB-4z7fA:
undetectable		 5e4dA-4z7fA:
23.11
5e4dB-4z7fA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4z7f FOLATE ECF
TRANSPORTER
(Enterococcus
faecalis) 		4 / 4 ASN A 162
ILE A  47
TYR A  91
PHE A  39
 None
 1.42A 5igvA-4z7fA:
undetectable		 5igvA-4z7fA:
18.63