SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 11 LEU A 615
GLU A 618
LEU A 682
HIS A 622
GLY A 675
 None
 1.16A 1cmaA-4z7gA:
undetectable
1cmaB-4z7gA:
undetectable		 1cmaA-4z7gA:
12.37
1cmaB-4z7gA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 ALA A 641
VAL A 586
ILE A 601
VAL A 566
ILE A 569
 None
 0.95A 1fb7A-4z7gA:
undetectable		 1fb7A-4z7gA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 10 MET A 708
LEU A 695
ALA A 647
GLU A 651
LEU A 577
 None
 1.29A 1gwrA-4z7gA:
undetectable		 1gwrA-4z7gA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 7 SER A 896
ASP A 899
TRP A 874
PHE A 937
 None
 1.27A 1ismB-4z7gA:
undetectable		 1ismB-4z7gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
 None
 1.33A 1l7fA-4z7gA:
undetectable		 1l7fA-4z7gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
 None
 1.33A 1l7gA-4z7gA:
undetectable		 1l7gA-4z7gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
 None
 1.34A 1l7hA-4z7gA:
undetectable		 1l7hA-4z7gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 LEU A 577
ALA A 597
LYS A 599
GLU A 612
LEU A 644
LEU A 695
ASP A 711
 None
 0.94A 1m17A-4z7gA:
19.9		 1m17A-4z7gA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 HIS A 622
GLY A 675
LEU A 615
GLU A 618
LEU A 682
 None
 1.19A 1mj2C-4z7gA:
undetectable
1mj2D-4z7gA:
undetectable		 1mj2C-4z7gA:
12.11
1mj2D-4z7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 9 LEU A 615
GLU A 618
LEU A 682
HIS A 622
GLY A 675
 None
 1.10A 1mjlA-4z7gA:
undetectable
1mjlB-4z7gA:
undetectable		 1mjlA-4z7gA:
12.11
1mjlB-4z7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 HIS A 622
GLY A 675
LEU A 615
GLU A 618
LEU A 682
 None
 1.20A 1mjoC-4z7gA:
undetectable
1mjoD-4z7gA:
undetectable		 1mjoC-4z7gA:
12.11
1mjoD-4z7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 11 LEU A 615
GLU A 618
LEU A 682
HIS A 622
GLY A 675
 None
 1.17A 1mjqA-4z7gA:
undetectable
1mjqB-4z7gA:
undetectable		 1mjqA-4z7gA:
12.11
1mjqB-4z7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 11 LEU A 615
GLU A 618
LEU A 682
HIS A 622
GLY A 675
 None
 1.22A 1mjqI-4z7gA:
undetectable
1mjqJ-4z7gA:
undetectable		 1mjqI-4z7gA:
12.11
1mjqJ-4z7gA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 10 MET A 708
LEU A 695
ALA A 647
GLU A 651
LEU A 577
 None
 1.34A 1qktA-4z7gA:
undetectable		 1qktA-4z7gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 7 ASP A 844
ASP A 847
LYS A 908
HIS A 909
 None
 1.28A 1t03A-4z7gA:
undetectable		 1t03A-4z7gA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 ALA A 597
GLU A 612
LEU A 616
CYH A 645
LEU A 679
HIS A 686
 None
 0.67A 1uwhA-4z7gA:
20.9		 1uwhA-4z7gA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 ALA A 597
GLU A 612
LEU A 616
CYH A 645
LEU A 679
HIS A 686
 None
 0.68A 1uwhB-4z7gA:
20.8		 1uwhB-4z7gA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 VAL A 586
ALA A 597
GLU A 612
CYH A 645
LEU A 679
HIS A 686
 None
 0.67A 1uwjA-4z7gA:
5.2		 1uwjA-4z7gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 VAL A 586
ALA A 597
GLU A 612
CYH A 645
LEU A 679
HIS A 686
 None
 0.66A 1uwjB-4z7gA:
5.2		 1uwjB-4z7gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 577
VAL A 586
ALA A 597
THR A 648
ASN A 693
ASP A 711
 None
 0.83A 2fumC-4z7gA:
21.9		 2fumC-4z7gA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		9 / 12 LEU A 577
GLY A 578
GLY A 580
VAL A 586
ALA A 597
THR A 648
LYS A 690
ASN A 693
ASP A 711
 None
 1.02A 2fumD-4z7gA:
21.7		 2fumD-4z7gA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 ILE A 813
ALA A 760
LEU A 669
PHE A 831
LEU A 795
 None
 1.17A 2w3bB-4z7gA:
undetectable		 2w3bB-4z7gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 10 VAL A 586
ALA A 597
ILE A 626
LEU A 644
LEU A 695
ASP A 711
 None
 0.80A 2y7jB-4z7gA:
22.6		 2y7jB-4z7gA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 6 VAL A 625
LEU A 644
ILE A 684
ILE A 709
 NA  A1001 (-4.9A)
None
None
None
 0.61A 3gcsA-4z7gA:
17.1		 3gcsA-4z7gA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 VAL A 586
ALA A 597
GLU A 612
LEU A 615
LEU A 616
ILE A 626
HIS A 686
 None
 0.97A 3gp0A-4z7gA:
18.8		 3gp0A-4z7gA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 6 VAL A 625
ILE A 684
HIS A 686
ILE A 709
 NA  A1001 (-4.9A)
None
None
None
 0.27A 3hegA-4z7gA:
17.9		 3hegA-4z7gA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
 None
 1.36A 3k37A-4z7gA:
undetectable		 3k37A-4z7gA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 VAL A 586
ALA A 597
GLU A 612
LEU A 616
ILE A 626
LEU A 679
HIS A 686
 None
 0.76A 3rgfA-4z7gA:
19.1		 3rgfA-4z7gA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 577
GLY A 578
ALA A 597
GLU A 612
LEU A 616
CYH A 645
 None
 0.79A 3wzdA-4z7gA:
19.5		 3wzdA-4z7gA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 8 VAL A 625
CYH A 645
LEU A 695
ILE A 709
 NA  A1001 (-4.9A)
None
None
None
 0.30A 3wzeA-4z7gA:
20.2		 3wzeA-4z7gA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 ALA A 597
LYS A 599
GLU A 612
ILE A 626
LEU A 679
HIS A 686
LEU A 695
 None
 0.84A 3zosB-4z7gA:
19.0		 3zosB-4z7gA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 616
ILE A 640
ASP A 688
LYS A 690
ASN A 693
ASP A 711
 None
 1.03A 4an2A-4z7gA:
19.1		 4an2A-4z7gA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 616
ILE A 642
ASP A 688
LYS A 690
ASN A 693
ASP A 711
 None
 1.44A 4an2A-4z7gA:
19.1		 4an2A-4z7gA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		8 / 12 LEU A 577
VAL A 586
ALA A 597
LYS A 599
GLU A 612
LEU A 616
LEU A 679
HIS A 686
 None
 1.00A 4asdA-4z7gA:
20.0		 4asdA-4z7gA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 ALA A 597
LYS A 599
GLU A 612
LEU A 616
ILE A 640
HIS A 686
LEU A 695
 None
 0.91A 4c8bA-4z7gA:
21.4		 4c8bA-4z7gA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 LEU A 616
ILE A 642
ASN A 693
ASP A 711
PHE A 712
 None
 0.91A 4lmnA-4z7gA:
18.7		 4lmnA-4z7gA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 12 LEU A 950
ARG A 946
GLU A 949
GLU A 807
TYR A 961
 None
 1.32A 4mx0A-4z7gA:
undetectable		 4mx0A-4z7gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		9 / 11 LEU A 577
GLY A 578
VAL A 586
ALA A 597
LYS A 599
THR A 648
ASN A 693
LEU A 695
ASP A 711
 None
 0.68A 4o0sA-4z7gA:
21.7		 4o0sA-4z7gA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 6 ALA A 597
LYS A 599
THR A 648
LEU A 695
 None
 0.76A 4o0uA-4z7gA:
5.6		 4o0uA-4z7gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 6 VAL A 586
ALA A 597
THR A 648
LEU A 695
 None
 0.38A 4o0uA-4z7gA:
5.6		 4o0uA-4z7gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 6 LEU A 577
GLY A 578
VAL A 586
ALA A 597
THR A 648
LEU A 695
 None
 0.45A 4o0wA-4z7gA:
21.3		 4o0wA-4z7gA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 9 LEU A 577
VAL A 586
ILE A 626
ARG A 687
LEU A 695
ILE A 709
 None
 0.92A 4v01A-4z7gA:
19.6		 4v01A-4z7gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 9 LEU A 577
VAL A 586
ILE A 626
ARG A 687
LEU A 695
ILE A 709
 None
 0.82A 4v01B-4z7gA:
20.1		 4v01B-4z7gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 9 LEU A 577
VAL A 586
LYS A 599
ARG A 687
LEU A 695
ILE A 709
 None
 0.97A 4v01B-4z7gA:
20.1		 4v01B-4z7gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 8 LEU A 577
ALA A 597
LEU A 695
SER A 710
 None
 0.36A 4wboB-4z7gA:
17.6		 4wboB-4z7gA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 577
ALA A 597
LYS A 599
LEU A 644
GLU A 651
LEU A 695
 None
 0.99A 5h2uA-4z7gA:
20.0		 5h2uA-4z7gA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 577
VAL A 586
ALA A 597
LEU A 644
GLU A 651
LEU A 695
 None
 0.70A 5h2uA-4z7gA:
20.0		 5h2uA-4z7gA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 LEU A 577
VAL A 586
ALA A 597
ILE A 640
LEU A 644
LEU A 695
 None
 0.61A 5h2uD-4z7gA:
20.1		 5h2uD-4z7gA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 ALA A 597
GLU A 612
LEU A 616
CYH A 645
LEU A 679
HIS A 686
 None
 0.72A 5hi2A-4z7gA:
21.4		 5hi2A-4z7gA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		6 / 12 ALA A 597
GLU A 612
ILE A 626
ILE A 640
LEU A 695
SER A 710
 None
 0.69A 5i9xA-4z7gA:
20.8		 5i9xA-4z7gA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		3 / 3 HIS A 825
LYS A 824
PHE A 962
 None
 1.00A 5klaA-4z7gA:
undetectable		 5klaA-4z7gA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 10 GLY A 578
VAL A 586
ALA A 597
ILE A 626
LEU A 644
 None
 0.53A 5lw1E-4z7gA:
18.3		 5lw1E-4z7gA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 5 LEU A 616
CYH A 645
LEU A 695
ASP A 711
 None
 0.88A 5mafA-4z7gA:
21.9		 5mafA-4z7gA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 8 ALA A 597
GLU A 612
ILE A 642
CYH A 645
 None
 0.55A 5owrA-4z7gA:
17.6		 5owrA-4z7gA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 8 ALA A 597
ILE A 642
CYH A 645
LEU A 695
 None
 0.46A 5owrA-4z7gA:
17.6		 5owrA-4z7gA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		4 / 5 VAL A 586
LEU A 644
CYH A 645
ASP A 711
 None
 0.82A 5vcvA-4z7gA:
20.0		 5vcvA-4z7gA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		5 / 9 HIS A 692
GLY A 580
VAL A 586
GLY A 578
LEU A 577
 None
 1.29A 5wm2A-4z7gA:
undetectable		 5wm2A-4z7gA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 LEU A 577
VAL A 586
ALA A 597
GLU A 612
LEU A 644
CYH A 645
LEU A 695
 None
 0.77A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 LEU A 577
VAL A 586
ALA A 597
GLU A 612
LEU A 644
CYH A 645
LEU A 695
 None
 0.77A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 LEU A 577
VAL A 586
ALA A 597
LEU A 644
CYH A 645
GLU A 651
LEU A 695
 None
 0.85A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 LEU A 577
VAL A 586
ALA A 597
LEU A 644
CYH A 645
GLU A 651
LEU A 695
 None
 0.85A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		7 / 12 LEU A 577
GLY A 578
VAL A 586
ALA A 597
LYS A 599
LEU A 695
ASP A 711
 None
 1.11A 5yu9A-4z7gA:
18.6		 5yu9A-4z7gA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		3 / 3 MET A 742
ASP A 756
ARG A 611
 None
 0.86A 5z6jA-4z7gA:
undetectable		 5z6jA-4z7gA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens) 		3 / 3 MET A 742
ASP A 756
ARG A 611
 None
 0.95A 5z6kA-4z7gA:
undetectable		 5z6kA-4z7gA:
15.59