SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		4 / 6 LEU A  62
LYS A  55
ARG A  24
GLY A  20
 None
None
C  C  29 ( 4.1A)
None
 1.20A 2hs2B-4z7lA:
undetectable		 2hs2B-4z7lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 ILE A  79
LEU A  85
TYR A  10
PHE A  54
GLU A  82
 None
 1.28A 2no0A-4z7lA:
undetectable		 2no0A-4z7lA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 THR A 108
ILE A 163
GLY A 107
PHE A 106
ILE A 152
 None
A  C  23 ( 4.4A)
None
None
None
 1.42A 2y7kA-4z7lA:
undetectable		 2y7kA-4z7lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 10 THR A 108
ILE A 163
GLY A 107
PHE A 106
ILE A 152
 None
A  C  23 ( 4.4A)
None
None
None
 1.43A 2y7kB-4z7lA:
undetectable		 2y7kB-4z7lA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 7 THR A 108
ILE A 163
GLY A 107
PHE A 106
ILE A 152
 None
A  C  23 ( 4.4A)
None
None
None
 1.48A 2y7wC-4z7lA:
undetectable		 2y7wC-4z7lA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 ILE A  56
ILE A  57
GLY A 211
LEU A  62
VAL A 215
 None
 1.12A 2yvlA-4z7lA:
undetectable		 2yvlA-4z7lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 ILE A  56
ILE A  57
GLY A 211
LEU A  62
VAL A 215
 None
 1.10A 2yvlB-4z7lA:
undetectable		 2yvlB-4z7lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 ILE A  56
ILE A  57
GLY A 211
LEU A  62
VAL A 215
 None
 1.04A 2yvlC-4z7lA:
undetectable		 2yvlC-4z7lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 ILE A  79
LEU A  85
TYR A  10
PHE A  54
GLU A  82
 None
 1.36A 2ziaB-4z7lA:
undetectable		 2ziaB-4z7lA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 ILE A  56
SER A  60
PRO A  61
PRO A  11
SER A   9
 None
 1.07A 3bjwB-4z7lA:
undetectable		 3bjwB-4z7lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4z7l CAS6B
(Methanococcus
maripaludis) 		4 / 5 ILE A  56
SER A  60
PRO A  61
PRO A  11
 None
 1.07A 3bjwC-4z7lA:
undetectable		 3bjwC-4z7lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 ILE A  56
SER A  60
PRO A  61
PRO A  11
SER A   9
 None
 1.07A 3bjwH-4z7lA:
undetectable		 3bjwH-4z7lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 10 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.33A 3kz7A-4z7lA:
undetectable		 3kz7A-4z7lA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 10 LEU A 173
ALA A 123
ASN A 128
GLY A 150
ILE A 152
 None
None
A  C  26 ( 3.2A)
A  C  26 ( 3.2A)
None
 0.97A 3lzvA-4z7lA:
undetectable		 3lzvA-4z7lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.33A 3o5rA-4z7lA:
undetectable		 3o5rA-4z7lA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 10 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.37A 3uf8A-4z7lA:
undetectable		 3uf8A-4z7lA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 10 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.38A 3uqaA-4z7lA:
undetectable		 3uqaA-4z7lA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		4 / 8 TYR A  31
ILE A   8
ILE A  94
PHE A  27
 None
 0.79A 3uqbA-4z7lA:
undetectable		 3uqbA-4z7lA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.30A 3vawA-4z7lA:
undetectable		 3vawA-4z7lA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.27A 4drhA-4z7lA:
undetectable		 4drhA-4z7lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.22A 4drhD-4z7lA:
undetectable		 4drhD-4z7lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.25A 4driA-4z7lA:
undetectable		 4driA-4z7lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
GLU A  75
ILE A  63
TYR A  10
PHE A  27
 None
 1.27A 4drjA-4z7lA:
undetectable		 4drjA-4z7lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.33A 4drjA-4z7lA:
undetectable		 4drjA-4z7lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.30A 4dz2A-4z7lA:
undetectable
4dz2B-4z7lA:
undetectable		 4dz2A-4z7lA:
18.83
4dz2B-4z7lA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.29A 4dz2A-4z7lA:
undetectable
4dz2B-4z7lA:
undetectable		 4dz2A-4z7lA:
18.83
4dz2B-4z7lA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4z7l CAS6B
(Methanococcus
maripaludis) 		4 / 7 ILE A 194
LEU A 148
PHE A 117
GLY A 213
 None
 0.97A 4hc3A-4z7lA:
undetectable		 4hc3A-4z7lA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 10 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.28A 4laxA-4z7lA:
undetectable		 4laxA-4z7lA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4z7l CAS6B
(Methanococcus
maripaludis) 		4 / 6 GLU A 175
GLY A  20
ARG A 210
GLY A 211
 None
None
SO4  A 301 (-3.3A)
None
 0.86A 5cdnC-4z7lA:
2.2
5cdnD-4z7lA:
undetectable		 5cdnC-4z7lA:
19.45
5cdnD-4z7lA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 12 GLY A 213
GLY A 211
ILE A  57
ASN A 207
ASN A 151
 None
None
None
C  C  29 ( 3.1A)
A  C  26 ( 4.1A)
 1.11A 5fa8A-4z7lA:
undetectable		 5fa8A-4z7lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.24A 5hw8G-4z7lA:
undetectable		 5hw8G-4z7lA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4z7l CAS6B
(Methanococcus
maripaludis) 		5 / 11 TYR A  31
ILE A  63
TYR A  10
ILE A  94
PHE A  27
 None
 1.31A 5hwcA-4z7lA:
undetectable		 5hwcA-4z7lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		3 / 3 ASN A  39
PRO A  50
GLN A  51
 C  C  29 ( 3.6A)
G  C  28 ( 4.4A)
None
 0.68A 6jnhA-4z7lA:
undetectable		 6jnhA-4z7lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4z7l CAS6B
(Methanococcus
maripaludis) 		3 / 3 ASN A  39
PRO A  50
GLN A  51
 C  C  29 ( 3.6A)
G  C  28 ( 4.4A)
None
 0.66A 6jogA-4z7lA:
undetectable		 6jogA-4z7lA:
20.74