SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z7r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ILE A 250
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 0.96A 1hvyD-4z7rA:
undetectable		 1hvyD-4z7rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ASP A  59
ASP A 216
HIS A 265
THR A 269
GLY A  12
 None
None
ZN  A 302 (-3.3A)
None
None
 1.48A 1ia0B-4z7rA:
undetectable		 1ia0B-4z7rA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ASP A  59
ASP A 216
HIS A 265
THR A 269
GLY A  12
 None
None
ZN  A 302 (-3.3A)
None
None
 1.48A 1tubB-4z7rA:
undetectable		 1tubB-4z7rA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		4 / 8 ARG A  37
HIS A  93
SER A  40
VAL A 264
 None
ZN  A 302 ( 4.6A)
None
None
 1.20A 1u1jA-4z7rA:
undetectable		 1u1jA-4z7rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 THR A 111
VAL A 156
PHE A 143
TYR A 192
LEU A  54
 None
 1.31A 1wsvA-4z7rA:
undetectable		 1wsvA-4z7rA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 SER A 282
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 1.20A 2kceA-4z7rA:
undetectable		 2kceA-4z7rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		4 / 8 ALA A 197
HIS A 240
GLY A 172
ILE A 171
 None
 0.83A 2zm9A-4z7rA:
undetectable		 2zm9A-4z7rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ALA A  56
LEU A 100
SER A  79
PRO A  72
ALA A  43
 None
 1.05A 3dfrA-4z7rA:
undetectable		 3dfrA-4z7rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		4 / 5 PRO A 271
VAL A 272
THR A 247
GLY A 245
 None
 1.20A 3elzB-4z7rA:
undetectable		 3elzB-4z7rA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ILE A 250
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 1.15A 3k2hA-4z7rA:
undetectable		 3k2hA-4z7rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 11 ALA A 191
ARG A 189
ILE A 193
GLY A 180
LEU A 213
 None
 1.24A 3kw2A-4z7rA:
undetectable		 3kw2A-4z7rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 11 ALA A 191
ARG A 189
ILE A 193
GLY A 180
LEU A 213
 None
 1.26A 3kw2B-4z7rA:
undetectable		 3kw2B-4z7rA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 11 PHE A 106
VAL A  84
PHE A 124
GLY A  96
LEU A  86
 None
 1.17A 3t3rA-4z7rA:
undetectable		 3t3rA-4z7rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ILE A 258
GLY A 287
SER A 282
VAL A 272
LEU A 220
 None
 1.20A 3v8vA-4z7rA:
undetectable		 3v8vA-4z7rA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ILE A 250
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 1.00A 4foxA-4z7rA:
undetectable		 4foxA-4z7rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 11 ILE A 250
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 1.06A 4foxF-4z7rA:
undetectable		 4foxF-4z7rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ILE A 250
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 1.07A 4foxG-4z7rA:
undetectable		 4foxG-4z7rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		6 / 12 ASP A  92
GLY A  13
SER A  41
GLY A   7
ASP A 216
THR A 218
 ZN  A 302 (-2.3A)
None
None
None
None
None
 1.38A 4mm8A-4z7rA:
undetectable		 4mm8A-4z7rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 GLY A  12
SER A  41
GLY A   7
ASP A 216
THR A 218
 None
 1.13A 4mm8A-4z7rA:
undetectable		 4mm8A-4z7rA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		3 / 3 ARG A 261
TRP A 288
ILE A 258
 None
 1.11A 4mwxA-4z7rA:
undetectable		 4mwxA-4z7rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		4 / 6 TRP A 288
GLY A 245
ILE A 241
PHE A 215
 None
 1.09A 4qogA-4z7rA:
undetectable
4qogB-4z7rA:
undetectable		 4qogA-4z7rA:
23.36
4qogB-4z7rA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		4 / 8 THR A 269
GLY A  12
GLY A  13
VAL A  14
 None
 0.84A 4qvvK-4z7rA:
undetectable
4qvvL-4z7rA:
undetectable		 4qvvK-4z7rA:
22.15
4qvvL-4z7rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		4 / 8 THR A 269
GLY A  12
GLY A  13
VAL A  14
 None
 0.84A 4qvvY-4z7rA:
undetectable
4qvvZ-4z7rA:
undetectable		 4qvvY-4z7rA:
22.15
4qvvZ-4z7rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 11 ILE A 250
TRP A 288
LEU A 213
ASP A 216
GLY A 217
 None
 1.10A 5fctA-4z7rA:
undetectable		 5fctA-4z7rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 LEU A 190
LEU A 297
ALA A 212
ILE A 241
LEU A 203
 None
 1.11A 5h8tA-4z7rA:
undetectable		 5h8tA-4z7rA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 TYR A 192
VAL A   3
LEU A 297
ALA A 212
ILE A   5
 None
 1.02A 5hbsA-4z7rA:
undetectable		 5hbsA-4z7rA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		3 / 3 GLN A  63
THR A  38
ASP A 293
 None
 0.91A 5k9dA-4z7rA:
undetectable		 5k9dA-4z7rA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 11 ILE A  42
ASP A 293
GLY A 294
ASN A  67
ALA A   9
 None
 1.28A 6r2eF-4z7rA:
undetectable		 6r2eF-4z7rA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4z7r COENZYME PQQ
SYNTHESIS PROTEIN B
(Methylobacterium
extorquens) 		5 / 12 ILE A  42
ASP A 293
GLY A 294
ASN A  67
ALA A   9
 None
 1.29A 6r2eH-4z7rA:
undetectable		 6r2eH-4z7rA:
22.69