SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z7y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 270
LEU A 299
ILE A 307
ILE A 266
THR A 290
 None
 1.05A 1draB-4z7yA:
undetectable		 1draB-4z7yA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.17A 1jolA-4z7yA:
undetectable		 1jolA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 10 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.17A 1pxxD-4z7yA:
undetectable		 1pxxD-4z7yA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.16A 1tdrA-4z7yA:
undetectable		 1tdrA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 5 LEU A  39
PHE A 234
MET A 238
SER A 242
 None
 1.02A 1wrlC-4z7yA:
undetectable		 1wrlC-4z7yA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 270
LEU A 299
ILE A 307
ILE A 266
THR A 290
 None
 1.03A 2drcB-4z7yA:
undetectable		 2drcB-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 7 ARG A 144
ALA A 109
PRO A 319
ALA A   9
 None
 1.07A 2ejfA-4z7yA:
undetectable		 2ejfA-4z7yA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 SER A  36
GLY A 140
ALA A 142
LEU A 137
LEU A  29
 None
 0.90A 2nyuA-4z7yA:
undetectable		 2nyuA-4z7yA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 SER A  36
GLY A 140
ALA A 142
LEU A 137
LEU A  29
 None
 1.01A 2nyuB-4z7yA:
undetectable		 2nyuB-4z7yA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 9 ALA A 109
ALA A 113
GLY A 138
SER A 145
ALA A 142
 None
 1.30A 2vh3A-4z7yA:
undetectable		 2vh3A-4z7yA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 305
ILE A 182
LEU A  39
ILE A 311
ILE A  37
 None
 1.11A 2ygnA-4z7yA:
undetectable		 2ygnA-4z7yA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.25A 2zzaA-4z7yA:
undetectable		 2zzaA-4z7yA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
MET A 238
ILE A  13
LEU A  39
 None
 1.14A 2zzaA-4z7yA:
undetectable		 2zzaA-4z7yA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A 181
ALA A 276
MET A 238
ILE A  13
LEU A  39
 None
 1.14A 2zzaB-4z7yA:
undetectable		 2zzaB-4z7yA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 5 ALA A 105
ALA A  14
TYR A  18
MET A 245
 None
 1.10A 3d91A-4z7yA:
undetectable		 3d91A-4z7yA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 270
LEU A 299
ILE A 307
ILE A 266
THR A 290
 None
 1.04A 3drcB-4z7yA:
undetectable		 3drcB-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 9 VAL A  15
ILE A 182
ASP A 281
SER A 313
ILE A  37
 None
 1.41A 3hbbB-4z7yA:
undetectable		 3hbbB-4z7yA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
MET A 238
ILE A  13
LEU A  39
 None
 1.15A 3ia4B-4z7yA:
undetectable		 3ia4B-4z7yA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
MET A 238
ILE A  13
LEU A  39
 None
 1.11A 3ia4D-4z7yA:
undetectable		 3ia4D-4z7yA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 276
MET A 238
LEU A 178
ILE A  13
LEU A  39
 None
 1.11A 3ql0A-4z7yA:
undetectable		 3ql0A-4z7yA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
MET A 238
LEU A 178
LEU A  39
 None
 1.06A 3ql0A-4z7yA:
undetectable		 3ql0A-4z7yA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 270
LEU A 299
ILE A 307
ILE A 266
THR A 290
 None
 1.13A 3ql3A-4z7yA:
undetectable		 3ql3A-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ASN A  60
LEU A  64
THR A  47
VAL A  49
VAL A  57
 None
 0.85A 3rukA-4z7yA:
undetectable		 3rukA-4z7yA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 6 LEU A  35
VAL A  15
MET A 238
PHE A 234
 None
 1.13A 3soaA-4z7yA:
undetectable		 3soaA-4z7yA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 270
LEU A 299
ILE A 307
ILE A 266
THR A 290
 None
 1.02A 3tq9A-4z7yA:
undetectable		 3tq9A-4z7yA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		4 / 8 SER A 193
SER A 194
MET A 198
GLY A 283
 None
 0.98A 4af0A-4z7yA:
undetectable		 4af0A-4z7yA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		6 / 12 ILE A 181
ALA A 276
MET A 238
LEU A 178
ILE A  13
LEU A  39
 None
 1.21A 4p3rA-4z7yA:
undetectable		 4p3rA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
MET A 238
LEU A 178
ILE A  13
LEU A  39
 None
 1.06A 4psyA-4z7yA:
undetectable		 4psyA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.16A 4qi9B-4z7yA:
undetectable		 4qi9B-4z7yA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.13A 4qleA-4z7yA:
undetectable		 4qleA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.16A 4qleB-4z7yA:
undetectable		 4qleB-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.18A 4qlfA-4z7yA:
undetectable		 4qlfA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.12A 4qlgA-4z7yA:
undetectable		 4qlgA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		3 / 3 GLY A 318
PRO A 319
ALA A 113
 SO4  A 401 (-4.3A)
None
None
 0.37A 4qn9B-4z7yA:
undetectable		 4qn9B-4z7yA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
ALA A 276
LEU A 178
ILE A  13
LEU A  39
 None
 1.18A 4rgcA-4z7yA:
undetectable		 4rgcA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 181
MET A 238
LEU A 178
ILE A  13
LEU A  39
 None
 1.12A 4rgcA-4z7yA:
undetectable		 4rgcA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.08A 4rrwA-4z7yA:
undetectable		 4rrwA-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.09A 4rrwB-4z7yA:
undetectable		 4rrwB-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.08A 4rrwC-4z7yA:
undetectable		 4rrwC-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.09A 4rrwD-4z7yA:
undetectable		 4rrwD-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.08A 4rrzA-4z7yA:
undetectable		 4rrzA-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.09A 4rrzB-4z7yA:
undetectable		 4rrzB-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.08A 4rrzC-4z7yA:
undetectable		 4rrzC-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.09A 4rrzD-4z7yA:
undetectable		 4rrzD-4z7yA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 MET A 239
ASN A 243
TYR A 278
ILE A 182
ILE A 181
 None
 1.34A 4xueA-4z7yA:
undetectable		 4xueA-4z7yA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 270
LEU A 299
ILE A 307
ILE A 266
THR A 290
 None
 1.05A 5e8qA-4z7yA:
undetectable		 5e8qA-4z7yA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  92
TYR A  72
VAL A  45
ALA A 113
SER A 117
 None
 1.16A 5ikrA-4z7yA:
undetectable		 5ikrA-4z7yA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		3 / 3 ASN A  28
TYR A  18
CYH A 143
 None
 0.53A 5lsuB-4z7yA:
undetectable		 5lsuB-4z7yA:
20.36