SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		3 / 3 TRP A 407
VAL A 409
TRP A 457
 None
 1.15A 1c4dC-4z81A:
undetectable
1c4dD-4z81A:
undetectable		 1c4dC-4z81A:
2.82
1c4dD-4z81A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 5 TYR A 150
PRO A 401
LEU A 402
THR A 394
 None
 1.27A 1i2wA-4z81A:
undetectable		 1i2wA-4z81A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 4 GLY A 107
SER A 442
ILE A  73
HIS A 456
 None
 1.36A 1yajJ-4z81A:
undetectable		 1yajJ-4z81A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		3 / 3 ALA A 366
THR A 361
PHE A 351
 None
 0.79A 2c6nB-4z81A:
undetectable		 2c6nB-4z81A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		3 / 3 TYR A  97
VAL A 234
THR A  96
 None
 0.90A 2ygnA-4z81A:
undetectable		 2ygnA-4z81A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		5 / 12 ASN A 171
THR A 167
MET A 373
SER A 164
PHE A 156
 None
 1.47A 3g4lA-4z81A:
undetectable		 3g4lA-4z81A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 6 VAL A 409
ARG A 422
VAL A 485
TRP A 457
 None
 1.50A 3jx4A-4z81A:
undetectable
3jx4B-4z81A:
undetectable		 3jx4A-4z81A:
21.71
3jx4B-4z81A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 7 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.14A 4a97E-4z81A:
undetectable		 4a97E-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 8 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.10A 4a97D-4z81A:
undetectable		 4a97D-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 8 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.07A 4a97G-4z81A:
undetectable		 4a97G-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 7 PHE A 367
TYR A 368
VAL A 370
ILE A 154
 None
 1.11A 4a97H-4z81A:
undetectable		 4a97H-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 5 GLU A 195
GLU A 201
TYR A 346
HIS A 347
 None
 1.24A 4a97J-4z81A:
undetectable		 4a97J-4z81A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 7 TYR A 116
SER A 113
SER A 329
ARG A 328
 None
 1.23A 4lv9A-4z81A:
undetectable
4lv9B-4z81A:
undetectable		 4lv9A-4z81A:
20.86
4lv9B-4z81A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 6 GLU A 201
GLU A 172
TYR A 272
GLU A 195
 None
 1.42A 4mi4A-4z81A:
undetectable		 4mi4A-4z81A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		5 / 10 ASP A 350
VAL A 452
TYR A 109
GLY A 445
GLY A 107
 None
 1.30A 4xpbA-4z81A:
undetectable		 4xpbA-4z81A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 6 VAL A 409
ARG A 422
VAL A 485
TRP A 457
 None
 1.48A 5addA-4z81A:
undetectable
5addB-4z81A:
undetectable		 5addA-4z81A:
21.71
5addB-4z81A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 7 ALA A 537
THR A 538
VAL A 542
LYS A 540
 None
 1.24A 5ecnA-4z81A:
undetectable		 5ecnA-4z81A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 8 PRO A 148
TYR A 150
PHE A 305
SER A 308
 None
 1.02A 5l1fA-4z81A:
undetectable
5l1fB-4z81A:
undetectable		 5l1fA-4z81A:
20.27
5l1fB-4z81A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 6 HIS A 456
ASN A 149
VAL A 110
GLN A 349
 None
 1.44A 5xdhA-4z81A:
undetectable
5xdhC-4z81A:
undetectable		 5xdhA-4z81A:
9.84
5xdhC-4z81A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 7 GLU A 431
ARG A 476
THR A 474
PRO A 506
 None
 1.40A 6a4iB-4z81A:
undetectable		 6a4iB-4z81A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN
(Toxoplasma
gondii) 		4 / 6 GLU A 393
ARG A  92
PHE A 305
VAL A 384
 None
 1.23A 6fgdA-4z81A:
undetectable		 6fgdA-4z81A:
21.22