SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 VAL A 375
ALA A 215
ILE A 389
ILE A 379
THR A 212
 None
 1.10A 1d1gB-4z8gA:
undetectable		 1d1gB-4z8gA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		4 / 4 ASP A 373
LEU A 405
GLY A 401
ARG A 409
 None
 1.30A 2j2pD-4z8gA:
undetectable
2j2pE-4z8gA:
undetectable		 2j2pD-4z8gA:
17.37
2j2pE-4z8gA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 11 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
 1.13A 2qd3A-4z8gA:
undetectable		 2qd3A-4z8gA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 ILE A 399
ASN A 201
ILE A 379
ALA A 380
LEU A 420
 None
NI  A 509 (-4.0A)
None
None
None
 0.92A 3a50A-4z8gA:
undetectable		 3a50A-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.76A 3a50A-4z8gA:
undetectable		 3a50A-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 11 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.75A 3a50C-4z8gA:
undetectable		 3a50C-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 ILE A 399
ASN A 201
ILE A 379
ALA A 380
LEU A 420
 None
NI  A 509 (-4.0A)
None
None
None
 0.87A 3a50D-4z8gA:
undetectable		 3a50D-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.77A 3a50E-4z8gA:
undetectable		 3a50E-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 11 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.84A 3a51A-4z8gA:
undetectable		 3a51A-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.79A 3a51C-4z8gA:
undetectable		 3a51C-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.81A 3a51D-4z8gA:
undetectable		 3a51D-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 ILE A 399
ASN A 201
ILE A 379
ALA A 380
LEU A 420
 None
NI  A 509 (-4.0A)
None
None
None
 0.96A 3a51E-4z8gA:
undetectable		 3a51E-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.80A 3a51E-4z8gA:
undetectable		 3a51E-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 11 VAL A 375
ALA A 215
ILE A 389
LEU A 392
ILE A 379
THR A 212
 None
 1.18A 3clbA-4z8gA:
undetectable		 3clbA-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 12 ALA A 215
ILE A 190
ILE A 389
LEU A 392
ILE A 379
THR A 212
 None
 1.22A 3clbC-4z8gA:
undetectable		 3clbC-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 12 VAL A 375
ALA A 215
ILE A 389
LEU A 392
ILE A 379
THR A 212
 None
 1.15A 3clbC-4z8gA:
undetectable		 3clbC-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 10 VAL A 375
ALA A 215
ILE A 389
ILE A 379
THR A 212
 None
 1.02A 3clbD-4z8gA:
undetectable		 3clbD-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 10 VAL A 375
ALA A 215
ILE A 389
LEU A 392
ILE A 379
 None
 1.14A 3hbbA-4z8gA:
undetectable		 3hbbA-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 11 ALA A 215
ILE A 190
ILE A 389
LEU A 392
ILE A 379
THR A 212
 None
 1.28A 3hbbC-4z8gA:
undetectable		 3hbbC-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 11 VAL A 375
ALA A 215
ILE A 389
LEU A 392
ILE A 379
THR A 212
 None
 1.15A 3hbbC-4z8gA:
undetectable		 3hbbC-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 10 VAL A 375
ALA A 215
ILE A 389
ILE A 379
THR A 212
 None
 1.03A 3hbbD-4z8gA:
undetectable		 3hbbD-4z8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 10 LEU A 417
ALA A 410
GLY A 403
ILE A 404
LEU A 383
 None
 1.08A 3ogpB-4z8gA:
undetectable		 3ogpB-4z8gA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 10 LEU A 417
ALA A 410
ILE A 381
GLY A 403
ILE A 404
LEU A 383
 None
 1.34A 3ogpA-4z8gA:
undetectable		 3ogpA-4z8gA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		6 / 10 LEU A 417
ALA A 410
ILE A 381
GLY A 403
ILE A 404
LEU A 383
 None
 1.38A 3ogqA-4z8gA:
undetectable		 3ogqA-4z8gA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 LEU A 417
ALA A 410
GLY A 403
ILE A 404
LEU A 383
 None
 1.00A 3ogqB-4z8gA:
undetectable		 3ogqB-4z8gA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		3 / 3 ASN A 386
ALA A 385
LYS A 387
 None
 0.92A 3runA-4z8gA:
undetectable		 3runA-4z8gA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
 1.15A 4f4dA-4z8gA:
undetectable		 4f4dA-4z8gA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)
(Homo
sapiens) 		5 / 12 LEU A 420
LEU A 450
LEU A 467
ILE A 407
THR A 462
 None
 1.08A 4f4dB-4z8gA:
undetectable		 4f4dB-4z8gA:
16.99