SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OHT_A_1N1A2000_1 (P38A)	4z8n	RETICULOCYTE-BINDING PROTEIN 2A (Plasmodium vivax)	5 / 12	ILE A 290 ILE A 310 ILE A 191 ALA A 201 TYR A 205	None	1.13A	3ohtA-4z8nA: 0.6 3ohtB-4z8nA: 1.1	3ohtA-4z8nA: 20.94 3ohtB-4z8nA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V2Z_C_Y70C151_1 (CEREBLON ISOFORM 4)	4z8n	RETICULOCYTE-BINDING PROTEIN 2A (Plasmodium vivax)	4 / 8	ASN A 415 PHE A 416 PHE A 411 TYR A 308	None	1.48A	4v2zC-4z8nA: undetectable	4v2zC-4z8nA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BMV_C_VLBC507_1 (TUBULIN BETA CHAIN TUBULIN ALPHA-1B CHAIN)	4z8n	RETICULOCYTE-BINDING PROTEIN 2A (Plasmodium vivax)	4 / 6	LYS A 192 TYR A 205 TYR A 410 LEU A 294	None	1.35A	5bmvB-4z8nA: undetectable	5bmvB-4z8nA: 19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FUK_A_SNPA1236_1 (MROUPO)	4z8n	RETICULOCYTE-BINDING PROTEIN 2A (Plasmodium vivax)	4 / 7	ILE A 174 ILE A 382 THR A 429 LEU A 424	None	0.74A	5fukA-4z8nA: undetectable 5fukB-4z8nA: undetectable	5fukA-4z8nA: 20.56 5fukB-4z8nA: 20.56

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3OHT_A_1N1A2000_1","P38A;P38A","4z8n","RETICULOCYTE-BINDING PROTEIN 2A","Plasmodium vivax",5,"ILE A 290;ILE A 310;ILE A 191;ALA A 201;TYR A 205","None","1.13A","3ohtA-4z8nA:0.6;3ohtB-4z8nA:1.1","3ohtA-4z8nA:20.94;3ohtB-4z8nA:20.94"],["4V2Z_C_Y70C151_1","CEREBLON ISOFORM 4","4z8n","RETICULOCYTE-BINDING PROTEIN 2A","Plasmodium vivax",4,"ASN A 415;PHE A 416;PHE A 411;TYR A 308","None","1.48A","4v2zC-4z8nA:undetectable","4v2zC-4z8nA:15.38"],["5BMV_C_VLBC507_1","TUBULIN BETA CHAIN;TUBULIN ALPHA-1B CHAIN","4z8n","RETICULOCYTE-BINDING PROTEIN 2A","Plasmodium vivax",4,"LYS A 192;TYR A 205;TYR A 410;LEU A 294","None","1.35A","5bmvB-4z8nA:undetectable","5bmvB-4z8nA:19.61"],["5FUK_A_SNPA1236_1","MROUPO;MROUPO","4z8n","RETICULOCYTE-BINDING PROTEIN 2A","Plasmodium vivax",4,"ILE A 174;ILE A 382;THR A 429;LEU A 424","None","0.74A","5fukA-4z8nA:undetectable;5fukB-4z8nA:undetectable","5fukA-4z8nA:20.56;5fukB-4z8nA:20.56"]]