SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		4 / 6 ARG A  77
TYR A  76
PHE A  97
PHE A 151
 None
 1.27A 1e73M-4z8sA:
undetectable		 1e73M-4z8sA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		4 / 7 THR A  26
ASN A  20
LEU A  50
GLN A  24
 None
 0.96A 1qzrB-4z8sA:
undetectable		 1qzrB-4z8sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 11 LEU A  54
ILE A 114
ILE A 155
VAL A 158
LEU A 159
 None
 0.94A 3w67A-4z8sA:
undetectable		 3w67A-4z8sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 12 LEU A  54
ILE A 114
ILE A 155
VAL A 158
LEU A 159
 None
 0.94A 3w67B-4z8sA:
undetectable		 3w67B-4z8sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 12 LEU A  54
ILE A 114
ILE A 155
VAL A 158
LEU A 159
 None
 0.99A 3w68D-4z8sA:
undetectable		 3w68D-4z8sA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 11 LEU A  39
SER A 198
LEU A 197
PHE A 164
ALA A  71
 None
 1.26A 4hwkB-4z8sA:
undetectable		 4hwkB-4z8sA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 12 LEU A  39
SER A 198
LEU A 197
PHE A 164
ALA A  71
 None
 1.25A 4hwkC-4z8sA:
undetectable		 4hwkC-4z8sA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 11 LEU A  39
SER A 198
LEU A 197
PHE A 164
ALA A  71
 None
 1.27A 4hwkD-4z8sA:
undetectable		 4hwkD-4z8sA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		4 / 6 GLY A 128
ILE A 167
ILE A 175
LEU A   4
 None
 0.72A 4o8fB-4z8sA:
undetectable		 4o8fB-4z8sA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		3 / 3 ARG A  22
LYS A  15
GLU A 168
 None
 0.65A 5d0yA-4z8sA:
undetectable		 5d0yA-4z8sA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 10 ALA A  75
ILE A  91
ILE A  45
PHE A  49
ALA A  65
 None
 1.21A 5nukA-4z8sA:
undetectable		 5nukA-4z8sA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		3 / 3 GLU A 144
HIS A 142
ARG A  81
 None
 0.97A 5uunA-4z8sA:
0.5		 5uunA-4z8sA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		4 / 6 PHE A 107
SER A 150
HIS A 142
TYR A  76
 None
 1.11A 5ycnA-4z8sA:
undetectable		 5ycnA-4z8sA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4z8s RRNA N-GLYCOSIDASE
(Momordica
charantia) 		5 / 11 PHE A 166
SER A 220
ALA A 186
THR A 182
LEU A 127
 None
 1.19A 6efnA-4z8sA:
undetectable		 6efnA-4z8sA:
19.61