SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
ZN  A 701 (-3.3A)
 1.07A 1q23A-4z8xA:
undetectable		 1q23A-4z8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
ZN  A 701 (-3.3A)
 1.09A 1q23F-4z8xA:
undetectable		 1q23F-4z8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 4 ALA A 478
VAL A 482
ALA A 479
HIS A 418
 None
None
None
ZN  A 701 (-3.3A)
 0.98A 1q23K-4z8xA:
undetectable		 1q23K-4z8xA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		3 / 3 ASP A 287
PHE A 240
ASN A 280
 None
 0.86A 1sg9B-4z8xA:
undetectable		 1sg9B-4z8xA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		3 / 3 PRO A 177
GLY A 294
TYR A 173
 None
 0.62A 2vouA-4z8xA:
undetectable		 2vouA-4z8xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		3 / 3 PRO A 177
GLY A 294
TYR A 173
 None
 0.61A 2vouB-4z8xA:
undetectable		 2vouB-4z8xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		3 / 3 PRO A 177
GLY A 294
TYR A 173
 None
 0.60A 2vouC-4z8xA:
undetectable		 2vouC-4z8xA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 8 GLY A 190
ILE A 217
MET A 250
CYH A 249
 None
 0.92A 3ko0O-4z8xA:
undetectable
3ko0Q-4z8xA:
undetectable		 3ko0O-4z8xA:
12.24
3ko0Q-4z8xA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 6 LEU A 239
PHE A 240
ILE A 251
CYH A 249
 None
 0.98A 3ko0S-4z8xA:
undetectable		 3ko0S-4z8xA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		5 / 12 ILE A 171
PHE A 154
ILE A 160
LEU A 204
VAL A 167
 None
 1.11A 3s3vA-4z8xA:
undetectable		 3s3vA-4z8xA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 7 GLY A 492
ALA A 493
ASP A 496
ILE A 417
 None
None
ZN  A 701 (-2.2A)
None
 0.69A 3t3cA-4z8xA:
undetectable		 3t3cA-4z8xA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		5 / 11 GLY A 492
ALA A 493
ASP A 496
GLY A 475
ILE A 417
 None
None
ZN  A 701 (-2.2A)
None
None
 0.83A 3ufnA-4z8xA:
undetectable		 3ufnA-4z8xA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		5 / 12 HIS A 338
GLY A 200
GLY A 362
LEU A 365
LEU A 204
 ADP  A 702 ( 4.1A)
ADP  A 702 ( 3.4A)
ADP  A 702 ( 3.6A)
None
None
 1.09A 3vywB-4z8xA:
undetectable		 3vywB-4z8xA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 5 GLY A 476
GLY A 475
MET A 425
GLU A 480
 None
 1.27A 4fglC-4z8xA:
undetectable		 4fglC-4z8xA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		5 / 12 THR A 361
ALA A 363
ASP A 364
GLU A 366
LEU A 203
 None
ADP  A 702 ( 3.4A)
None
ADP  A 702 ( 2.7A)
ADP  A 702 ( 3.7A)
 1.32A 4xi3A-4z8xA:
3.4		 4xi3A-4z8xA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 7 GLY A 492
ALA A 493
ASP A 496
ILE A 417
 None
None
ZN  A 701 (-2.2A)
None
 0.64A 5kqyB-4z8xA:
undetectable		 5kqyB-4z8xA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4z8x ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH
(Aquifex
aeolicus) 		4 / 8 GLY A 492
ALA A 493
ASP A 496
ILE A 417
 None
None
ZN  A 701 (-2.2A)
None
 0.63A 5kr1B-4z8xA:
undetectable		 5kr1B-4z8xA:
12.53