SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
3 / 3 PHE A  45
LEU A  36
SER A 162
GDP  A 201 (-4.4A)
None
GDP  A 201 (-3.4A)
0.70A 1e7aA-4z8yA:
undetectable
1e7aA-4z8yA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
5 / 12 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
None
0.88A 2rctA-4z8yA:
undetectable
2rctA-4z8yA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
5 / 10 ASP A  56
ARG A  83
ILE A  85
LEU A  37
GLY A  78
None
1.27A 2v0mA-4z8yA:
undetectable
2v0mA-4z8yA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
5 / 12 ILE A  97
ILE A  96
GLY A  27
LEU A  24
PHE A  82
None
1.28A 2yvlC-4z8yA:
undetectable
2yvlC-4z8yA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
5 / 12 ILE A 156
TYR A 100
VAL A 102
LEU A 130
LEU A  36
None
0.88A 4qynA-4z8yA:
undetectable
4qynA-4z8yA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
3 / 3 LYS A  33
GLN A 113
ASN A 110
GDP  A 201 (-2.7A)
None
None
0.79A 5l2tA-4z8yA:
undetectable
5l2tA-4z8yA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
4 / 6 VAL A  62
LEU A  71
LEU A  73
LEU A 176
None
0.71A 6f6sA-4z8yA:
undetectable
6f6sB-4z8yA:
undetectable
6f6sA-4z8yA:
18.71
6f6sB-4z8yA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4z8y RAS-RELATED PROTEIN
SEC4

(Saccharomyces
cerevisiae)
5 / 12 ILE A  23
ALA A 177
PHE A 173
LEU A  36
ILE A  97
None
1.09A 7dfrA-4z8yA:
undetectable
7dfrA-4z8yA:
23.28