SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 HIS A 302
LEU A 218
LEU A 225
LEU A  18
 None
 1.21A 1a4lD-4z8zA:
undetectable		 1a4lD-4z8zA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A  98
LEU A 108
GLY A 111
LEU A 306
 None
 0.83A 1gtiA-4z8zA:
undetectable		 1gtiA-4z8zA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ARG A  28
SER A 235
ASP A 231
LYS A 227
 None
 1.20A 1hwiB-4z8zA:
1.2		 1hwiB-4z8zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 144
ASP A 104
PHE A 147
SER A 187
LEU A 225
 None
 1.33A 1lhuA-4z8zA:
undetectable		 1lhuA-4z8zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ALA A 168
LEU A  71
GLU A 167
LEU A  43
 None
 0.86A 1mt1D-4z8zA:
undetectable
1mt1E-4z8zA:
undetectable		 1mt1D-4z8zA:
15.48
1mt1E-4z8zA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 GLY A 101
SER A 187
ILE A 274
HIS A 302
 None
 1.09A 1yajJ-4z8zA:
6.0		 1yajJ-4z8zA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 SER A 269
ASP A 272
PRO A 211
LEU A  98
 None
 1.01A 2hdnE-4z8zA:
undetectable
2hdnF-4z8zA:
3.3
2hdnH-4z8zA:
3.2		 2hdnE-4z8zA:
7.69
2hdnF-4z8zA:
19.79
2hdnH-4z8zA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A  98
SER A 269
ASP A 272
PRO A 211
 None
 1.02A 2hdnF-4z8zA:
3.3
2hdnG-4z8zA:
undetectable
2hdnH-4z8zA:
3.2		 2hdnF-4z8zA:
19.79
2hdnG-4z8zA:
7.69
2hdnH-4z8zA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 129
VAL A 184
GLY A 185
GLY A 189
LEU A 113
 None
 1.18A 3dh0A-4z8zA:
undetectable		 3dh0A-4z8zA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ILE A 248
THR A 257
PHE A 259
PHE A 194
 None
 1.14A 3em0A-4z8zA:
undetectable		 3em0A-4z8zA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ILE A 255
PHE A 283
HIS A 197
 None
 0.75A 3h0aA-4z8zA:
undetectable		 3h0aA-4z8zA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ALA A 168
LEU A  97
LEU A  84
VAL A  82
THR A  48
 None
 1.32A 3jw5A-4z8zA:
undetectable		 3jw5A-4z8zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 237
VAL A 219
LEU A 225
ALA A 150
LEU A 152
 None
 1.01A 3pghA-4z8zA:
undetectable		 3pghA-4z8zA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLN A 273
GLU A   3
LYS A   7
 None
 1.16A 3su9A-4z8zA:
undetectable		 3su9A-4z8zA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 129
PHE A 147
GLY A 185
LEU A 208
PHE A 283
 None
 1.28A 3tbgA-4z8zA:
undetectable		 3tbgA-4z8zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ALA A 265
ILE A 264
HIS A 197
GLY A 205
 None
 0.98A 3v4tH-4z8zA:
undetectable		 3v4tH-4z8zA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ILE A 264
LEU A 292
THR A 206
GLY A 190
PHE A 283
 None
 1.24A 4bwlC-4z8zA:
undetectable		 4bwlC-4z8zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 PHE A 131
ALA A 155
GLY A 144
ILE A 148
GLU A 128
 None
 1.13A 4dcmA-4z8zA:
undetectable		 4dcmA-4z8zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ILE A 163
PHE A 159
ALA A 158
HIS A 197
LEU A 183
 None
 1.01A 4nqaA-4z8zA:
undetectable		 4nqaA-4z8zA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LYS A 310
LEU A 311
LEU A 296
VAL A 267
 None
 0.92A 4uswA-4z8zA:
undetectable		 4uswA-4z8zA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 163
PHE A  40
ARG A 195
ILE A 249
 None
 1.18A 4zzcA-4z8zA:
undetectable
4zzcB-4z8zA:
undetectable		 4zzcA-4z8zA:
22.63
4zzcB-4z8zA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ILE A 163
PHE A  40
ARG A 195
ILE A 249
 None
 1.20A 4zzcB-4z8zA:
undetectable
4zzcC-4z8zA:
undetectable		 4zzcB-4z8zA:
22.63
4zzcC-4z8zA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 PHE A 207
HIS A 197
LEU A 183
LEU A 182
 None
 1.22A 5dzke-4z8zA:
2.1
5dzks-4z8zA:
undetectable		 5dzke-4z8zA:
22.43
5dzks-4z8zA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A 237
VAL A 219
LEU A 225
ALA A 150
LEU A 152
 None
 1.10A 5iktB-4z8zA:
undetectable		 5iktB-4z8zA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 9 LEU A  71
ILE A 249
LEU A 199
PRO A 130
ALA A 158
 None
 1.06A 5og9A-4z8zA:
undetectable		 5og9A-4z8zA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 4z8z UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 MET A 188
GLY A 101
HIS A 100
GLY A 189
 None
 1.27A 6fgdA-4z8zA:
3.8		 6fgdA-4z8zA:
20.63