SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z94'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		3 / 3 VAL G  45
VAL G  22
TRP G  20
 None
 0.77A 1av2C-4z94G:
undetectable
1av2D-4z94G:
undetectable		 1av2C-4z94G:
4.68
1av2D-4z94G:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 VAL G1375
ALA G1215
ILE G1389
ILE G1379
THR G1212
 None
 1.10A 1d1gB-4z94G:
undetectable		 1d1gB-4z94G:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 4 HIS G  62
ASP G  85
ASN G  89
ASP G  60
 None
 1.27A 1wg8A-4z94G:
undetectable		 1wg8A-4z94G:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 5 ASP G1373
LEU G1405
GLY G1401
ARG G1409
 None
 1.14A 2j2pA-4z94G:
undetectable
2j2pB-4z94G:
undetectable		 2j2pA-4z94G:
21.85
2j2pB-4z94G:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 4 ASP G1373
LEU G1405
GLY G1401
ARG G1409
 None
 1.14A 2j2pD-4z94G:
undetectable
2j2pE-4z94G:
undetectable		 2j2pD-4z94G:
21.85
2j2pE-4z94G:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 LEU G1420
LEU G1450
LEU G1467
ILE G1407
THR G1462
 None
 1.12A 2qd3A-4z94G:
2.4		 2qd3A-4z94G:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		3 / 3 ASN G  54
ASN G  56
ARG G  91
 None
 0.91A 2rlcA-4z94G:
undetectable		 2rlcA-4z94G:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 5 LEU G  47
GLN G  58
THR G  49
THR G  81
 None
 1.02A 2zj0B-4z94G:
undetectable		 2zj0B-4z94G:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 5 LEU G  47
GLN G  58
THR G  49
THR G  81
 None
 0.99A 2zj0C-4z94G:
undetectable		 2zj0C-4z94G:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 4 LEU G  47
GLN G  58
THR G  49
THR G  81
 None
 1.04A 2zj0D-4z94G:
undetectable		 2zj0D-4z94G:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 ILE G1399
ASN G1201
ILE G1379
ALA G1380
LEU G1420
 None
 1.02A 3a50A-4z94G:
undetectable		 3a50A-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.82A 3a50A-4z94G:
undetectable		 3a50A-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.80A 3a50C-4z94G:
undetectable		 3a50C-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 ILE G1399
ASN G1201
ILE G1379
ALA G1380
LEU G1420
 None
 0.96A 3a50D-4z94G:
undetectable		 3a50D-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.87A 3a50E-4z94G:
undetectable		 3a50E-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.89A 3a51A-4z94G:
undetectable		 3a51A-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.84A 3a51C-4z94G:
undetectable		 3a51C-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.86A 3a51D-4z94G:
undetectable		 3a51D-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 ILE G1399
ASN G1201
ILE G1379
ALA G1380
LEU G1420
 None
 1.08A 3a51E-4z94G:
undetectable		 3a51E-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.90A 3a51E-4z94G:
undetectable		 3a51E-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 5 LEU G  47
GLN G  58
THR G  49
THR G  81
 None
 1.02A 3ce6B-4z94G:
undetectable		 3ce6B-4z94G:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 VAL G1375
ALA G1215
ILE G1389
ILE G1379
THR G1212
 None
 1.03A 3clbA-4z94G:
2.1		 3clbA-4z94G:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		6 / 12 ALA G1215
ILE G1190
ILE G1389
LEU G1392
ILE G1379
THR G1212
 None
 1.24A 3clbC-4z94G:
2.7		 3clbC-4z94G:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		6 / 12 VAL G1375
ALA G1215
ILE G1389
LEU G1392
ILE G1379
THR G1212
 None
 1.16A 3clbC-4z94G:
2.7		 3clbC-4z94G:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 10 VAL G1375
ALA G1215
ILE G1389
ILE G1379
THR G1212
 None
 1.00A 3clbD-4z94G:
2.4		 3clbD-4z94G:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 VAL G1375
ALA G1215
ILE G1389
ILE G1379
THR G1212
 None
 1.01A 3hbbC-4z94G:
2.7		 3hbbC-4z94G:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 10 VAL G1375
ALA G1215
ILE G1389
ILE G1379
THR G1212
 None
 1.01A 3hbbD-4z94G:
2.8		 3hbbD-4z94G:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		3 / 3 VAL G  45
VAL G  22
TRP G  20
 None
 0.86A 3l8lA-4z94G:
undetectable
3l8lB-4z94G:
undetectable		 3l8lA-4z94G:
4.68
3l8lB-4z94G:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		6 / 10 LEU G1417
ALA G1410
ILE G1381
GLY G1403
ILE G1404
LEU G1383
 None
 1.33A 3ogqA-4z94G:
undetectable		 3ogqA-4z94G:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 PHE G1422
ASN G1424
HIS G1453
GLY G1451
GLY G1430
 None
 1.33A 4a6nB-4z94G:
undetectable		 4a6nB-4z94G:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 LEU G1366
LEU G1394
LEU G1420
ILE G1389
ILE G1379
 None
 1.11A 4a7aB-4z94G:
undetectable		 4a7aB-4z94G:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_A_MIYA391_1
(TETX2 PROTEIN)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 10 PHE G1422
ASN G1424
HIS G1453
GLY G1451
GLY G1430
 None
 1.32A 4a99A-4z94G:
undetectable		 4a99A-4z94G:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_B_MIYB391_1
(TETX2 PROTEIN)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 PHE G1422
ASN G1424
HIS G1453
GLY G1451
GLY G1430
 None
 1.33A 4a99B-4z94G:
undetectable		 4a99B-4z94G:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 PHE G1422
ASN G1424
HIS G1453
GLY G1451
GLY G1430
 None
 1.32A 4a99C-4z94G:
undetectable		 4a99C-4z94G:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 11 PHE G1422
ASN G1424
HIS G1453
GLY G1451
GLY G1430
 None
 1.31A 4a99D-4z94G:
undetectable		 4a99D-4z94G:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 LEU G1420
LEU G1450
LEU G1467
ILE G1407
THR G1462
 None
 1.11A 4f4dA-4z94G:
undetectable		 4f4dA-4z94G:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		5 / 12 LEU G1420
LEU G1450
LEU G1467
ILE G1407
THR G1462
 None
 1.06A 4f4dB-4z94G:
2.4		 4f4dB-4z94G:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 7 TYR G 109
ILE G  46
LEU G 114
GLY G  36
 None
 0.89A 4iqqB-4z94G:
undetectable		 4iqqB-4z94G:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 5 GLY G 124
ASP G  72
GLU G  23
VAL G  45
 None
 0.95A 4nkvD-4z94G:
undetectable		 4nkvD-4z94G:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 5 GLU G1184
TYR G1216
ILE G1208
THR G1212
 None
 1.28A 4qwpB-4z94G:
undetectable		 4qwpB-4z94G:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens) 		4 / 7 PHE G1408
ARG G1460
THR G1464
LEU G1467
 None
 0.92A 5b1bN-4z94G:
undetectable
5b1bW-4z94G:
undetectable		 5b1bN-4z94G:
18.49
5b1bW-4z94G:
12.14