SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 4 GLU A 655
MET A 648
LEU A 651
SER A 652
 None
 1.22A 1ee2B-4z96A:
undetectable		 1ee2B-4z96A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		5 / 9 PHE A 903
LEU A1009
VAL A 992
ILE A 949
ILE A1005
 None
 1.42A 1gebA-4z96A:
undetectable		 1gebA-4z96A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LYS C1109
ASP A 764
MET A 761
GLU A 744
 None
 1.35A 3dh0A-4z96C:
undetectable		 3dh0A-4z96C:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 LEU A 941
ARG A 940
MET A 988
 None
 0.93A 4m11C-4z96A:
undetectable		 4m11C-4z96A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 ILE A 949
PRO A1006
HIS A1081
VAL A1043
 None
 1.32A 4s0vA-4z96A:
undetectable		 4s0vA-4z96A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		3 / 3 VAL A 685
PHE A 688
ARG A 634
 None
 0.66A 4xr4B-4z96A:
undetectable		 4xr4B-4z96A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens) 		4 / 5 LEU A 622
PHE A 661
LEU A 609
PHE A 594
 None
 1.22A 5x1fC-4z96A:
undetectable
5x1fJ-4z96A:
undetectable		 5x1fC-4z96A:
19.42
5x1fJ-4z96A:
8.11