SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.05A 1dfoA-4z9cA:
undetectable		 1dfoA-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.05A 1dfoB-4z9cA:
undetectable		 1dfoB-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.06A 1dfoC-4z9cA:
undetectable		 1dfoC-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.05A 1dfoD-4z9cA:
undetectable		 1dfoD-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.02A 1eqbA-4z9cA:
undetectable		 1eqbA-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.01A 1eqbB-4z9cA:
undetectable		 1eqbB-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.02A 1eqbC-4z9cA:
undetectable		 1eqbC-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 12 LEU A  36
GLY A  38
LEU A  32
VAL A  95
SER A  40
 None
 1.01A 1eqbD-4z9cA:
undetectable		 1eqbD-4z9cA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		4 / 8 LEU A 171
ARG A  30
LEU A  36
SER A  48
 None
 1.11A 1hk3A-4z9cA:
undetectable		 1hk3A-4z9cA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 10 LEU A  77
SER A  12
THR A 137
TYR A 138
PHE A  73
 None
 1.48A 1rqpA-4z9cA:
undetectable		 1rqpA-4z9cA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		5 / 10 LEU A  77
SER A  12
THR A 137
TYR A 138
PHE A  73
 None
 1.48A 1rqpC-4z9cA:
undetectable		 1rqpC-4z9cA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		3 / 3 PRO A  14
ASP A  11
ASP A  21
 None
 0.80A 1sqfA-4z9cA:
undetectable		 1sqfA-4z9cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		4 / 5 VAL A 220
LEU A 221
ILE A 182
ALA A 184
 None
 1.01A 3n8yB-4z9cA:
undetectable		 3n8yB-4z9cA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		3 / 3 ILE A  18
ASP A 201
ARG A   9
 None
 0.62A 4pstA-4z9cA:
undetectable		 4pstA-4z9cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA
(Escherichia
coli) 		4 / 8 PHE A  23
ILE A 130
THR A  60
LEU A 136
 None
 0.92A 5esjA-4z9cA:
undetectable		 5esjA-4z9cA:
18.89