SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 10 PHE A 206
THR A  83
LEU A  22
THR A 136
ASP A 103
 None
GSH  A 401 (-4.1A)
GSH  A 401 ( 4.7A)
GSH  A 401 ( 4.8A)
None
 1.36A 1o76A-4z9nA:
undetectable		 1o76A-4z9nA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 10 ILE A 201
GLY A 106
ILE A 128
LEU A 123
PHE A 144
 None
 1.13A 1z11C-4z9nA:
undetectable		 1z11C-4z9nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 THR A 136
GLY A 133
ALA A  63
TYR A 174
 GSH  A 401 ( 4.8A)
EDO  A 403 (-4.3A)
GSH  A 401 (-3.6A)
None
 0.77A 2a1hA-4z9nA:
undetectable
2a1hB-4z9nA:
undetectable		 2a1hA-4z9nA:
23.68
2a1hB-4z9nA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 ASN A 284
ILE A 278
THR A 237
ASN A 240
VAL A 320
 None
 1.43A 2gl0A-4z9nA:
undetectable
2gl0C-4z9nA:
undetectable		 2gl0A-4z9nA:
22.36
2gl0C-4z9nA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 ASN A 284
ILE A 278
THR A 237
ASN A 240
VAL A 320
 None
 1.42A 2gl0D-4z9nA:
undetectable
2gl0E-4z9nA:
undetectable		 2gl0D-4z9nA:
22.36
2gl0E-4z9nA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 11 ASN A 284
ILE A 278
THR A 237
ASN A 240
VAL A 320
 None
 1.45A 2gl0D-4z9nA:
undetectable
2gl0F-4z9nA:
undetectable		 2gl0D-4z9nA:
22.36
2gl0F-4z9nA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLN A 131
ALA A 162
ASP A 177
GLY A 183
LEU A 186
 GSH  A 401 (-3.1A)
None
GSH  A 401 (-3.0A)
None
None
 1.26A 2nv4B-4z9nA:
undetectable		 2nv4B-4z9nA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 5 SER A  47
GLY A 281
HIS A 225
ASP A  40
 None
 0.96A 2oxtB-4z9nA:
undetectable		 2oxtB-4z9nA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 9 ILE A 293
GLY A 294
GLY A 296
SER A  27
LEU A  23
 None
 1.00A 2qmmA-4z9nA:
undetectable		 2qmmA-4z9nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 9 ILE A 293
GLY A 294
SER A  35
SER A  27
LEU A  23
 None
 1.07A 2qmmA-4z9nA:
undetectable		 2qmmA-4z9nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 11 ILE A 293
GLY A 294
GLY A 296
SER A  27
LEU A  23
 None
 1.01A 2qmmA-4z9nA:
undetectable
2qmmB-4z9nA:
undetectable		 2qmmA-4z9nA:
20.43
2qmmB-4z9nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 LEU A 197
ILE A 128
PHE A 144
MET A 149
 None
 0.98A 2weyB-4z9nA:
undetectable		 2weyB-4z9nA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLY A 183
LEU A 188
ILE A 293
SER A 179
LEU A  22
 None
None
None
None
GSH  A 401 ( 4.7A)
 1.08A 2zbpA-4z9nA:
undetectable		 2zbpA-4z9nA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		3 / 3 PHE A 206
ASN A 100
PHE A  37
 None
 1.00A 2zbuD-4z9nA:
undetectable		 2zbuD-4z9nA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 11 GLY A 125
ALA A 126
ILE A 109
LEU A 121
ILE A 128
 None
 0.86A 3em4U-4z9nA:
undetectable		 3em4U-4z9nA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 LEU A 255
VAL A 320
ILE A 318
GLY A 317
HIS A 225
 None
 1.41A 3hgiA-4z9nA:
undetectable		 3hgiA-4z9nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 GLY A  24
PHE A  25
ILE A 159
PHE A 206
 None
None
GSH  A 401 (-3.6A)
None
 0.93A 3ko0O-4z9nA:
undetectable
3ko0Q-4z9nA:
undetectable		 3ko0O-4z9nA:
16.04
3ko0Q-4z9nA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 PHE A 144
VAL A 130
THR A 136
PHE A 107
 None
None
GSH  A 401 ( 4.8A)
None
 1.28A 3ltwA-4z9nA:
undetectable		 3ltwA-4z9nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 8 ARG A 303
GLY A  24
PHE A  25
SER A 297
 None
 1.11A 3tzfB-4z9nA:
undetectable		 3tzfB-4z9nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 5 SER A 202
GLY A 104
THR A  85
ASP A 177
 None
None
EDO  A 403 ( 4.9A)
GSH  A 401 (-3.0A)
 1.09A 4eohA-4z9nA:
undetectable		 4eohA-4z9nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 VAL A 195
ILE A 196
TYR A 182
ILE A 301
PRO A 191
 None
 1.13A 4nnrA-4z9nA:
undetectable
4nnrB-4z9nA:
undetectable		 4nnrA-4z9nA:
20.12
4nnrB-4z9nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 12 GLY A 207
TYR A 101
THR A  82
GLY A 104
PHE A  25
 None
None
GSH  A 401 (-4.3A)
None
None
 1.12A 5d4uB-4z9nA:
undetectable		 5d4uB-4z9nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 5 PHE A 289
ILE A 301
GLN A 315
ARG A 303
 None
 1.48A 5jm4A-4z9nA:
undetectable		 5jm4A-4z9nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 4 PHE A 289
ILE A 301
GLN A 315
ARG A 303
 None
 1.42A 5jm4B-4z9nA:
undetectable		 5jm4B-4z9nA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		3 / 3 LYS A   2
ASP A   7
ARG A 211
 None
 1.01A 5jwaA-4z9nA:
undetectable
5jwaH-4z9nA:
undetectable		 5jwaA-4z9nA:
21.54
5jwaH-4z9nA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 6 ASN A  81
ASN A  19
ARG A  66
ILE A 159
 GSH  A 401 (-3.3A)
GSH  A 401 (-3.2A)
GSH  A 401 (-3.1A)
GSH  A 401 (-3.6A)
 0.96A 5uigA-4z9nA:
undetectable		 5uigA-4z9nA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		5 / 10 TYR A 174
LEU A 181
LEU A 186
ALA A 187
GLU A 161
 None
 1.26A 5y7pG-4z9nA:
undetectable		 5y7pG-4z9nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN
(Brucella
ovis) 		4 / 5 TYR A 101
GLN A 315
GLY A 296
ILE A 293
 None
 1.27A 6debB-4z9nA:
undetectable		 6debB-4z9nA:
14.71