SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4z9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 ASP A  66
GLY A  16
ILE A  14
VAL A  77
ILE A  73
 None
 0.97A 1hpvB-4z9xA:
undetectable		 1hpvB-4z9xA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 ASP A  66
GLY A  16
ILE A  14
VAL A  77
ILE A  73
 None
 0.94A 1hxwA-4z9xA:
undetectable		 1hxwA-4z9xA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 TYR A 158
THR A 196
THR A 193
MET A 146
 None
 1.11A 1tv8A-4z9xA:
2.3		 1tv8A-4z9xA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  16
ASP A  40
ASP A  66
ASN A  93
ALA A  94
 None
 0.92A 2bm9E-4z9xA:
6.2		 2bm9E-4z9xA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 8 TYR A 158
THR A 196
THR A 193
MET A 146
 None
 1.11A 2fb2A-4z9xA:
undetectable		 2fb2A-4z9xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 TYR A 158
THR A 196
THR A 193
MET A 146
 None
 1.09A 2fb2B-4z9xA:
2.2		 2fb2B-4z9xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 TYR A  19
GLY A  22
ILE A  11
ALA A  26
ALA A  60
 None
 1.08A 3sudB-4z9xA:
undetectable		 3sudB-4z9xA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 SER A 145
ILE A  21
TYR A 158
GLY A 189
 None
 0.96A 3uboB-4z9xA:
6.8		 3uboB-4z9xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 ILE A 123
ASN A  92
LEU A 129
ILE A 181
PHE A 122
 None
 1.34A 4r38C-4z9xA:
undetectable		 4r38C-4z9xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 PHE A  38
ASP A  40
GLY A  62
SER A  18
 None
 1.35A 4xp9C-4z9xA:
undetectable		 4xp9C-4z9xA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 238
LEU A   7
SER A 242
ALA A 241
LYS A 139
 None
 1.13A 4ypmA-4z9xA:
2.7		 4ypmA-4z9xA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ASP A  66
GLY A  16
ILE A  14
VAL A  77
ILE A  73
 None
 0.86A 5kqxA-4z9xA:
undetectable		 5kqxA-4z9xA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4z9x GLUCONATE
5-DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 143
ILE A 186
THR A 169
ASN A 246
ILE A 249
 None
 1.10A 5lg3J-4z9xA:
undetectable		 5lg3J-4z9xA:
22.46