SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4za2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A  30
LEU A   8
GLY A  34
THR A  48
ILE A  28
 None
 1.39A 1p93A-4za2A:
undetectable		 1p93A-4za2A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 12 ALA A 187
GLY A 189
ILE A 143
ALA A 185
SER A 148
 None
 1.07A 1ve3B-4za2A:
6.2		 1ve3B-4za2A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 9 GLY A  25
ILE A 186
THR A 169
VAL A  90
VAL A 120
 None
 1.17A 2nnhB-4za2A:
undetectable		 2nnhB-4za2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 12 SER A 148
SER A 161
ASN A  92
VAL A 168
VAL A 183
 None
 1.22A 2nniA-4za2A:
undetectable		 2nniA-4za2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		4 / 8 ILE A 143
ASN A 116
SER A 161
SER A 145
 None
 1.15A 2zw9B-4za2A:
5.9		 2zw9B-4za2A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 9 VAL A 165
GLY A  94
ILE A  95
ALA A 160
ILE A 117
 None
 0.90A 3el0B-4za2A:
undetectable		 3el0B-4za2A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 12 LEU A  30
CYH A  18
THR A  48
VAL A  52
PHE A  59
 None
 1.23A 3gn8B-4za2A:
undetectable		 3gn8B-4za2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 12 THR A  16
LEU A 115
ILE A  95
HIS A  72
LEU A  14
 None
 1.44A 3gwxB-4za2A:
undetectable		 3gwxB-4za2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		3 / 3 LYS A 107
ARG A  97
ASP A  65
 None
 1.44A 3o7wA-4za2A:
5.5		 3o7wA-4za2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_SAMB503_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE
(Pectobacterium
carotovorum) 		5 / 12 GLN A 222
GLY A  23
ASN A  92
MET A 225
THR A  48
 None
 1.45A 5yf0B-4za2A:
4.8		 5yf0B-4za2A:
21.25