SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 LEU A  56
LEU A 182
VAL A 139
PHE A  64
ILE A 263
 None
 1.33A 1uobA-4zaaA:
undetectable		 1uobA-4zaaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 ILE A 171
GLY A 155
LEU A 211
ILE A  66
SER A  72
 FZZ  A 602 ( 3.7A)
None
None
None
None
 1.23A 1zq9A-4zaaA:
undetectable		 1zq9A-4zaaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 LEU A 137
GLY A  62
ILE A 310
PRO A 140
VAL A 139
 None
 0.96A 2nnkA-4zaaA:
undetectable		 2nnkA-4zaaA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 9 PHE A 213
SER A 261
ALA A 210
LEU A 211
GLY A 155
 None
 1.21A 2wscA-4zaaA:
undetectable		 2wscA-4zaaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 9 PHE A 213
SER A 261
ALA A 210
LEU A 211
GLY A 155
 None
 1.21A 2wseA-4zaaA:
undetectable		 2wseA-4zaaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 9 PHE A 213
SER A 261
ALA A 210
LEU A 211
GLY A 155
 None
 1.19A 2wsfA-4zaaA:
undetectable		 2wsfA-4zaaA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zaa FDC1
(Aspergillus
niger) 		4 / 8 THR A 323
ASP A 321
SER A 314
TYR A 150
 FZZ  A 602 (-4.7A)
None
FZZ  A 602 ( 3.9A)
None
 1.36A 2xz5A-4zaaA:
undetectable
2xz5C-4zaaA:
undetectable		 2xz5A-4zaaA:
18.76
2xz5C-4zaaA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 TYR A 298
VAL A 186
THR A 183
 None
 0.90A 2ygnA-4zaaA:
undetectable		 2ygnA-4zaaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4zaa FDC1
(Aspergillus
niger) 		5 / 9 VAL A 237
GLY A 238
GLY A 242
LEU A  88
ALA A 218
 None
 0.94A 2z0yB-4zaaA:
undetectable		 2z0yB-4zaaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 PHE A 437
TRP A 193
PRO A 438
LEU A 439
VAL A 434
 4M4  A 606 (-4.7A)
None
None
4M4  A 606 ( 4.2A)
None
 0.93A 3av6A-4zaaA:
undetectable		 3av6A-4zaaA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 PHE A  10
VAL A 215
ALA A 212
ALA A 309
ILE A 171
 None
None
None
None
FZZ  A 602 ( 3.7A)
 1.16A 3dl9B-4zaaA:
undetectable		 3dl9B-4zaaA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 THR A 241
LEU A   8
GLY A 214
ILE A 158
LEU A 245
 None
 0.98A 3ijdA-4zaaA:
undetectable		 3ijdA-4zaaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 VAL A 400
VAL A 456
TRP A 359
 None
 0.88A 3l8lA-4zaaA:
undetectable
3l8lB-4zaaA:
undetectable		 3l8lA-4zaaA:
6.63
3l8lB-4zaaA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4zaa FDC1
(Aspergillus
niger) 		5 / 9 PHE A 213
SER A 261
ALA A 210
LEU A 211
GLY A 155
 None
 1.21A 3lw5A-4zaaA:
undetectable		 3lw5A-4zaaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 GLU A 233
ALA A 234
TRP A 166
GLY A 238
LEU A 245
 MN  A 603 ( 2.7A)
None
None
None
None
 1.26A 3ou6C-4zaaA:
undetectable		 3ou6C-4zaaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 GLU A 233
ALA A 234
TRP A 166
GLY A 238
LEU A 245
 MN  A 603 ( 2.7A)
None
None
None
None
 1.25A 3ou6D-4zaaA:
undetectable		 3ou6D-4zaaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 ILE A 192
LEU A 182
LEU A 269
ALA A 296
ILE A 171
 None
None
None
None
FZZ  A 602 ( 3.7A)
 1.06A 3vrmA-4zaaA:
undetectable		 3vrmA-4zaaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 TRP A 472
TRP A 416
THR A 420
 None
 1.33A 4bboB-4zaaA:
undetectable		 4bboB-4zaaA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LEU A 430
ARG A 380
MET A 462
 None
 0.85A 4m11C-4zaaA:
undetectable		 4m11C-4zaaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_1
(RETINOL-BINDING
PROTEIN 2)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LYS A 391
TRP A 166
GLN A 194
 FZZ  A 602 ( 2.6A)
None
None
 1.07A 4qzuC-4zaaA:
0.0		 4qzuC-4zaaA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 PRO A 189
ILE A 227
GLU A 282
THR A 395
TYR A 394
 None
None
CO2  A 608 ( 4.8A)
4M4  A 606 (-4.3A)
4M4  A 606 (-3.4A)
 1.22A 4rfqA-4zaaA:
0.0		 4rfqA-4zaaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 ASP A 407
ARG A 363
TYR A 409
 None
 0.91A 5a7mA-4zaaA:
undetectable		 5a7mA-4zaaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 ASP A 407
ARG A 363
TYR A 409
 None
 0.92A 5a7mB-4zaaA:
undetectable		 5a7mB-4zaaA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4zaa FDC1
(Aspergillus
niger) 		4 / 6 LEU A 330
LYS A 391
TRP A 166
GLN A 194
 None
FZZ  A 602 ( 2.6A)
None
None
 1.36A 5h8tA-4zaaA:
undetectable		 5h8tA-4zaaA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 HIS A 191
GLU A 233
TRP A 166
 MN  A 603 (-3.4A)
MN  A 603 ( 2.7A)
None
 1.18A 5odiD-4zaaA:
undetectable		 5odiD-4zaaA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 HIS A 191
GLU A 233
TRP A 166
 MN  A 603 (-3.4A)
MN  A 603 ( 2.7A)
None
 1.21A 5odqD-4zaaA:
undetectable		 5odqD-4zaaA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LYS A 297
HIS A 181
HIS A 177
 None
 0.98A 5oexA-4zaaA:
undetectable		 5oexA-4zaaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LYS A 297
HIS A 181
HIS A 177
 None
 0.93A 5oexB-4zaaA:
undetectable		 5oexB-4zaaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LYS A 297
HIS A 181
HIS A 177
 None
 0.94A 5oexC-4zaaA:
undetectable		 5oexC-4zaaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 4zaa FDC1
(Aspergillus
niger) 		3 / 3 LYS A 297
HIS A 181
HIS A 177
 None
 0.95A 5oexD-4zaaA:
undetectable		 5oexD-4zaaA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 11 GLY A  82
LEU A  17
ALA A  16
PHE A  13
HIS A  87
 None
None
4M4  A 607 (-3.3A)
None
None
 1.26A 6qgbA-4zaaA:
undetectable		 6qgbA-4zaaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 10 GLY A  82
LEU A  17
ALA A  16
PHE A  13
HIS A  87
 None
None
4M4  A 607 (-3.3A)
None
None
 1.26A 6qgbB-4zaaA:
undetectable		 6qgbB-4zaaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 10 GLY A  82
LEU A  17
ALA A  16
PHE A  13
HIS A  87
 None
None
4M4  A 607 (-3.3A)
None
None
 1.26A 6qgbD-4zaaA:
undetectable		 6qgbD-4zaaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 11 GLY A  82
LEU A  17
ALA A  16
PHE A  13
HIS A  87
 None
None
4M4  A 607 (-3.3A)
None
None
 1.27A 6qgbE-4zaaA:
undetectable		 6qgbE-4zaaA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4zaa FDC1
(Aspergillus
niger) 		5 / 10 GLY A  82
LEU A  17
ALA A  16
PHE A  13
HIS A  87
 None
None
4M4  A 607 (-3.3A)
None
None
 1.25A 6qgbF-4zaaA:
undetectable		 6qgbF-4zaaA:
22.89