SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 4zad FDC1
(Candida
dubliniensis) 		5 / 10 SER A 339
VAL A 338
LEU A 409
GLY A 336
HIS A 291
 None
 1.33A 1equA-4zadA:
undetectable		 1equA-4zadA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 SER A 339
VAL A 338
LEU A 409
GLY A 336
HIS A 291
 None
 1.24A 1fdsA-4zadA:
undetectable		 1fdsA-4zadA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4zad FDC1
(Candida
dubliniensis) 		4 / 7 SER A 457
PHE A 295
ALA A 453
PHE A 450
 None
 1.24A 1fxvA-4zadA:
undetectable
1fxvB-4zadA:
undetectable		 1fxvA-4zadA:
17.10
1fxvB-4zadA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4zad FDC1
(Candida
dubliniensis) 		4 / 4 GLY A 190
LEU A 191
GLY A 180
ARG A 179
 None
4LU  A 603 (-4.1A)
None
None
 1.25A 1j7kA-4zadA:
undetectable		 1j7kA-4zadA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 LEU A   7
ALA A   6
GLY A 245
ILE A 244
LEU A 337
 None
 1.17A 1kglA-4zadA:
undetectable		 1kglA-4zadA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 PHE A 272
PHE A 220
PHE A  68
 None
 0.85A 2od9A-4zadA:
undetectable		 2od9A-4zadA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 PHE A 272
PHE A 220
PHE A  68
 None
 0.85A 2qqgA-4zadA:
undetectable		 2qqgA-4zadA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 TRP A 163
GLN A 196
TRP A 205
 None
4LU  A 603 (-3.4A)
None
 1.09A 2vqyA-4zadA:
undetectable		 2vqyA-4zadA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zad FDC1
(Candida
dubliniensis) 		4 / 8 MET A  99
ILE A  87
ASP A 328
SER A 321
 None
None
None
4LU  A 603 ( 3.7A)
 1.00A 2xytE-4zadA:
undetectable		 2xytE-4zadA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zad FDC1
(Candida
dubliniensis) 		4 / 8 MET A  99
ILE A  87
ASP A 328
SER A 321
 None
None
None
4LU  A 603 ( 3.7A)
 1.09A 2xytH-4zadA:
undetectable		 2xytH-4zadA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4zad FDC1
(Candida
dubliniensis) 		4 / 7 MET A  99
ILE A  87
ASP A 328
SER A 321
 None
None
None
4LU  A 603 ( 3.7A)
 1.09A 2xytI-4zadA:
undetectable		 2xytI-4zadA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 LYS A 343
LYS A 372
VAL A 358
 None
 1.10A 3brfA-4zadA:
undetectable		 3brfA-4zadA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 GLY A 246
GLY A 245
PRO A   5
VAL A  15
LEU A  89
 None
 0.93A 3m6wA-4zadA:
undetectable		 3m6wA-4zadA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4zad FDC1
(Candida
dubliniensis) 		4 / 8 ILE A 102
GLN A  96
LEU A  91
LEU A 337
 None
 0.74A 3ozwA-4zadA:
undetectable		 3ozwA-4zadA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4zad FDC1
(Candida
dubliniensis) 		4 / 6 HIS A 131
GLU A 269
ASP A  11
ASP A 314
 None
 1.09A 3vywA-4zadA:
undetectable		 3vywA-4zadA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 ARG A 434
PHE A 476
PRO A 477
 None
 0.81A 3zoaB-4zadA:
undetectable		 3zoaB-4zadA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4zad FDC1
(Candida
dubliniensis) 		4 / 8 ILE A  70
PRO A  50
ILE A  25
ILE A  38
 None
 0.94A 4dtaB-4zadA:
undetectable		 4dtaB-4zadA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 LEU A 378
LEU A 381
ILE A 373
HIS A 348
VAL A 392
 None
 1.22A 4f4dA-4zadA:
undetectable		 4f4dA-4zadA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 LEU A 378
LEU A 381
ILE A 373
HIS A 348
VAL A 392
 None
 1.22A 4f4dB-4zadA:
undetectable		 4f4dB-4zadA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 GLN A 166
ASN A 174
LEU A 262
VAL A 264
LEU A 120
 None
MN  A 601 ( 2.6A)
None
None
None
 1.50A 4k36B-4zadA:
undetectable		 4k36B-4zadA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 LEU A 381
LYS A 382
THR A 383
 None
 0.63A 4lj0A-4zadA:
undetectable		 4lj0A-4zadA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_1
(RETINOL-BINDING
PROTEIN 2)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 LYS A 404
TRP A 172
GLN A 200
 4LU  A 603 (-2.6A)
None
None
 1.09A 4qzuC-4zadA:
0.0		 4qzuC-4zadA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4zad FDC1
(Candida
dubliniensis) 		4 / 7 GLU A 242
TYR A 243
GLU A 240
ARG A 110
 None
None
MN  A 601 (-2.8A)
None
 1.43A 4r87J-4zadA:
undetectable
4r87L-4zadA:
undetectable		 4r87J-4zadA:
15.53
4r87L-4zadA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 4zad FDC1
(Candida
dubliniensis) 		5 / 12 HIS A  90
SER A 231
GLY A 221
PHE A  12
GLY A  72
 None
4LU  A 603 (-2.9A)
None
None
None
 1.33A 4uinH-4zadA:
undetectable
4uinL-4zadA:
undetectable		 4uinH-4zadA:
16.41
4uinL-4zadA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4zad FDC1
(Candida
dubliniensis) 		4 / 6 LEU A 337
LYS A 404
TRP A 172
GLN A 200
 None
4LU  A 603 (-2.6A)
None
None
 1.42A 5h8tA-4zadA:
undetectable		 5h8tA-4zadA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4zad FDC1
(Candida
dubliniensis) 		4 / 5 ASP A 152
HIS A 150
GLY A  36
ALA A  37
 None
 1.04A 5hwaA-4zadA:
undetectable		 5hwaA-4zadA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4zad FDC1
(Candida
dubliniensis) 		3 / 3 HIS A 197
GLU A 240
TRP A 172
 MN  A 601 ( 3.5A)
MN  A 601 (-2.8A)
None
 1.22A 5odiD-4zadA:
undetectable		 5odiD-4zadA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4zad FDC1
(Candida
dubliniensis) 		4 / 8 ILE A 157
LEU A 218
LEU A 276
LEU A 304
 None
 0.85A 5y7pE-4zadA:
undetectable		 5y7pE-4zadA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4zad FDC1
(Candida
dubliniensis) 		4 / 7 PHE A  80
LEU A  22
ALA A  48
ALA A  49
 None
 0.83A 6a7jA-4zadA:
undetectable		 6a7jA-4zadA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4zad FDC1
(Candida
dubliniensis) 		4 / 5 PRO A 118
VAL A 254
GLY A 161
VAL A 164
 None
 1.12A 6ak3B-4zadA:
undetectable		 6ak3B-4zadA:
12.35