SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zaj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 255
ASP A 578
LYS A 432
 None
 1.09A 1lqtB-4zajA:
4.3		 1lqtB-4zajA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 255
ASP A 578
LYS A 432
 None
 1.08A 1lquB-4zajA:
3.8		 1lquB-4zajA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 HIS A 136
GLY A 138
HIS A 139
GLN A 340
VAL A 372
 None
 0.56A 1qu2A-4zajA:
12.6		 1qu2A-4zajA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 HIS A 136
GLY A 138
HIS A 139
GLN A 340
VAL A 372
LYS A 379
 None
 0.83A 1qu3A-4zajA:
14.9		 1qu3A-4zajA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 479
LYS A 485
ARG A 488
 None
 0.98A 1ra8A-4zajA:
undetectable		 1ra8A-4zajA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 155
ILE A 149
ILE A 516
VAL A 160
PHE A 126
 None
 1.23A 1sg9A-4zajA:
2.3		 1sg9A-4zajA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 502
ILE A 469
ARG A 468
ILE A 492
LEU A 103
 None
 1.23A 1tw4B-4zajA:
undetectable		 1tw4B-4zajA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ARG A 440
HIS A 139
ARG A 141
VAL A 336
 None
 1.23A 1u1jA-4zajA:
2.6		 1u1jA-4zajA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 4 SER A 100
TRP A 561
ASP A 479
ILE A 478
 None
 1.11A 2oxtD-4zajA:
2.5		 2oxtD-4zajA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 10 CYH A 240
ILE A 239
ILE A 131
VAL A 166
GLY A 262
 None
 1.29A 3em0A-4zajA:
undetectable		 3em0A-4zajA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 522
GLY A 576
VAL A 572
ILE A 516
ILE A   4
 None
 1.03A 3frqB-4zajA:
undetectable		 3frqB-4zajA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 394
GLY A 395
TYR A 428
ILE A 431
PHE A 446
 None
 1.11A 3gwwA-4zajA:
2.1		 3gwwA-4zajA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ILE A 506
GLY A 503
SER A 105
LEU A 106
ALA A 568
 None
 1.15A 3kw2A-4zajA:
2.5		 3kw2A-4zajA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ILE A 506
GLY A 503
SER A 105
LEU A 106
ALA A 568
 None
 1.15A 3kw2B-4zajA:
undetectable		 3kw2B-4zajA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ILE A 332
TYR A 334
GLN A 352
LEU A 163
 None
 0.86A 3ozwA-4zajA:
4.7		 3ozwA-4zajA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.45A 3w9tA-4zajA:
undetectable		 3w9tA-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.44A 3w9tB-4zajA:
undetectable		 3w9tB-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.44A 3w9tC-4zajA:
undetectable		 3w9tC-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.43A 3w9tD-4zajA:
undetectable		 3w9tD-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.44A 3w9tE-4zajA:
undetectable		 3w9tE-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.44A 3w9tF-4zajA:
undetectable		 3w9tF-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 371
GLY A 370
TYR A 444
ASP A 435
 None
 1.45A 3w9tG-4zajA:
undetectable		 3w9tG-4zajA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 LEU A 152
VAL A 124
TYR A 158
LEU A 520
 None
 1.10A 4b3qA-4zajA:
2.0		 4b3qA-4zajA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ILE A 506
LEU A 107
ALA A 571
ALA A 574
ILE A 529
 None
 1.15A 4h1nA-4zajA:
undetectable		 4h1nA-4zajA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 470
ASP A 578
ASP A 255
 None
 0.76A 4kicB-4zajA:
undetectable		 4kicB-4zajA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 GLN A 181
HIS A 179
ILE A 177
ILE A 239
 None
 1.17A 5dnvA-4zajA:
2.5		 5dnvA-4zajA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ARG A 261
LEU A 163
PHE A 126
LEU A 161
 None
 1.23A 5iy5P-4zajA:
2.5
5iy5W-4zajA:
undetectable		 5iy5P-4zajA:
16.86
5iy5W-4zajA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ILE A 431
LEU A 398
LEU A 254
ALA A 253
LEU A 452
 None
 1.10A 5ji0A-4zajA:
undetectable		 5ji0A-4zajA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 PHE A  38
SER A  33
GLU A  83
ASP A  40
 None
 1.04A 5n5dB-4zajA:
undetectable		 5n5dB-4zajA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 VAL A  30
TYR A  41
GLN A  42
 None
 0.59A 5qgkA-4zajA:
undetectable		 5qgkA-4zajA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 VAL A  30
TYR A  41
GLN A  42
 None
 0.59A 5qgrA-4zajA:
undetectable		 5qgrA-4zajA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 VAL A  30
TYR A  41
GLN A  42
 None
 0.61A 5qgtA-4zajA:
undetectable		 5qgtA-4zajA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ILE A 529
ILE A 149
LEU A 152
PHE A 365
 None
 1.10A 5vkqA-4zajA:
2.4
5vkqB-4zajA:
2.4		 5vkqA-4zajA:
16.49
5vkqB-4zajA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ARG A 261
LEU A 163
PHE A 126
LEU A 161
 None
 1.22A 5x1fC-4zajA:
2.4
5x1fJ-4zajA:
undetectable		 5x1fC-4zajA:
17.02
5x1fJ-4zajA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ARG A 261
LEU A 163
PHE A 126
LEU A 161
 None
 1.21A 5xdxC-4zajA:
2.6
5xdxJ-4zajA:
undetectable		 5xdxC-4zajA:
16.86
5xdxJ-4zajA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ARG A 261
LEU A 163
PHE A 126
LEU A 161
 None
 1.25A 5xdxP-4zajA:
2.5
5xdxW-4zajA:
undetectable		 5xdxP-4zajA:
16.86
5xdxW-4zajA:
8.91