SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zas'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 VAL A 332
VAL A 360
TRP A 143
 None
 0.92A 1av2C-4zasA:
undetectable
1av2D-4zasA:
undetectable		 1av2C-4zasA:
3.59
1av2D-4zasA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.13A 1hrkB-4zasA:
2.3		 1hrkB-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 VAL A 139
LEU A 169
LEU A  70
SER A  71
LEU A  68
 None
 1.45A 1mmkA-4zasA:
undetectable		 1mmkA-4zasA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 VAL A 332
VAL A 360
TRP A 143
 None
 0.91A 1w5uC-4zasA:
undetectable
1w5uD-4zasA:
undetectable		 1w5uC-4zasA:
3.59
1w5uD-4zasA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 THR A  91
LEU A  90
ILE A 138
VAL A 170
MET A 122
 None
 1.10A 1wsvA-4zasA:
undetectable		 1wsvA-4zasA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 THR A  91
LEU A  90
ILE A 138
VAL A 170
MET A 122
 None
 1.07A 1wsvB-4zasA:
undetectable		 1wsvB-4zasA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 6 GLU A 285
ASP A 283
PHE A 305
ARG A 297
 None
 1.38A 2a3bB-4zasA:
undetectable		 2a3bB-4zasA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 MET A 307
GLY A 145
PHE A 305
ALA A 177
TYR A 196
 None
 1.27A 2avdB-4zasA:
undetectable		 2avdB-4zasA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.31A 2hrcA-4zasA:
undetectable		 2hrcA-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.09A 2hrcB-4zasA:
2.8		 2hrcB-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.19A 2pnjB-4zasA:
2.7		 2pnjB-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.36A 2qd2A-4zasA:
undetectable		 2qd2A-4zasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 LEU A 214
PRO A 215
LEU A 219
 None
 0.48A 2qd5B-4zasA:
undetectable		 2qd5B-4zasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 VAL A  56
GLY A  52
PHE A 211
VAL A 213
GLY A  48
 None
 0.80A 2v0zC-4zasA:
undetectable		 2v0zC-4zasA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 VAL A  56
GLY A  52
PHE A 211
VAL A 213
GLY A  48
 None
 0.84A 2v0zO-4zasA:
undetectable		 2v0zO-4zasA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.43A 3hcoA-4zasA:
undetectable		 3hcoA-4zasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.26A 3hcoB-4zasA:
undetectable		 3hcoB-4zasA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 VAL A 332
VAL A 360
TRP A 143
 None
 0.96A 3l8lC-4zasA:
undetectable
3l8lD-4zasA:
undetectable		 3l8lC-4zasA:
3.59
3l8lD-4zasA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 ALA A  46
GLY A 258
GLY A 261
GLU A  42
VAL A  40
 None
 0.97A 3o7wA-4zasA:
2.6		 3o7wA-4zasA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4zas CALS13
(Micromonospora
echinospora) 		4 / 5 LEU A  68
SER A  71
ARG A  75
LEU A 223
 None
 0.94A 3onnA-4zasA:
undetectable		 3onnA-4zasA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 GLY A 209
GLY A  62
THR A  63
TYR A 196
GLY A 199
 None
LLP  A 202 ( 3.5A)
LLP  A 202 ( 3.6A)
None
LLP  A 202 ( 4.3A)
 1.06A 3sglA-4zasA:
undetectable		 3sglA-4zasA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 ASP A 173
LEU A 204
GLY A 199
SER A 197
ALA A 177
 LLP  A 202 ( 2.9A)
None
LLP  A 202 ( 4.3A)
LLP  A 202 ( 2.8A)
None
 1.05A 3sufA-4zasA:
undetectable		 3sufA-4zasA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 LEU A 214
PRO A 215
LEU A 219
 None
 0.45A 3w1wB-4zasA:
2.3		 3w1wB-4zasA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 GLY A  65
ALA A 137
ILE A 103
VAL A 139
VAL A 171
 None
 1.06A 4nkxC-4zasA:
undetectable		 4nkxC-4zasA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 9 ARG A 315
SER A 330
THR A 329
LEU A  12
ILE A 362
 None
 1.29A 4ubsA-4zasA:
undetectable		 4ubsA-4zasA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 10 ALA A 356
LEU A 352
GLY A 351
ILE A 103
LEU A  70
 None
 1.25A 5oy01-4zasA:
undetectable
5oy07-4zasA:
undetectable		 5oy01-4zasA:
11.83
5oy07-4zasA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 GLU A  35
HIS A  36
ARG A 227
 None
 0.92A 5uunA-4zasA:
undetectable		 5uunA-4zasA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 THR A 329
LEU A 322
VAL A 312
SER A 382
ILE A 289
 None
 1.40A 5w8aA-4zasA:
undetectable		 5w8aA-4zasA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 ASN A 254
GLY A 209
PHE A 211
GLU A  44
ILE A 260
 None
 1.06A 6ectA-4zasA:
2.1		 6ectA-4zasA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4zas CALS13
(Micromonospora
echinospora) 		3 / 3 HIS A  36
ARG A 250
ILE A 252
 None
 0.78A 6fgdA-4zasA:
undetectable		 6fgdA-4zasA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 12 TYR A 308
ASP A 283
ARG A 297
VAL A 292
ILE A 289
 None
 1.15A 6mkeB-4zasA:
undetectable
6mkeC-4zasA:
undetectable		 6mkeB-4zasA:
10.86
6mkeC-4zasA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4zas CALS13
(Micromonospora
echinospora) 		5 / 10 TYR A 308
ASP A 283
ARG A 297
VAL A 292
ILE A 289
 None
 1.21A 6mkeC-4zasA:
undetectable		 6mkeC-4zasA:
10.86