SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		5 / 11 ALA A  76
ILE A  23
VAL A  71
THR A 166
ALA A 168
 None
 1.18A 1rv7A-4zb8A:
undetectable
1rv7B-4zb8A:
undetectable		 1rv7A-4zb8A:
17.94
1rv7B-4zb8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		3 / 3 ALA A 165
VAL A 161
TRP A 106
 None
 0.81A 1tkqB-4zb8A:
undetectable		 1tkqB-4zb8A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 5 GLY A  18
PRO A  59
ILE A  77
ILE A  78
 None
GDS  A 300 (-4.4A)
None
None
 0.84A 2q9rA-4zb8A:
undetectable		 2q9rA-4zb8A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		3 / 3 GLY A 113
TYR A 117
SER A 112
 None
 0.75A 2xatA-4zb8A:
undetectable		 2xatA-4zb8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		3 / 3 THR A  97
SER A  92
LYS A 164
 None
 0.94A 3aocC-4zb8A:
undetectable		 3aocC-4zb8A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 4 PRO A 174
LEU A 173
ILE A 209
ARG A 206
 None
 1.30A 3w1wA-4zb8A:
undetectable		 3w1wA-4zb8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 6 LEU A 150
SER A 171
PHE A 170
GLU A  27
 None
 1.14A 5b8iA-4zb8A:
undetectable		 5b8iA-4zb8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 175
PRO A  59
GLY A  15
PRO A  16
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.4A)
GDS  A 300 (-3.6A)
GDS  A 300 (-4.2A)
 1.08A 5kf8A-4zb8A:
undetectable		 5kf8A-4zb8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 175
PRO A  59
GLY A  15
PRO A  16
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.4A)
GDS  A 300 (-3.6A)
GDS  A 300 (-4.2A)
 1.12A 5kgpA-4zb8A:
undetectable		 5kgpA-4zb8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 TRP A 175
PRO A  59
GLY A  15
PRO A  16
 GDS  A 300 (-4.0A)
GDS  A 300 (-4.4A)
GDS  A 300 (-3.6A)
GDS  A 300 (-4.2A)
 1.12A 5kgpB-4zb8A:
undetectable		 5kgpB-4zb8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 8 LEU A   9
TYR A  32
GLU A  26
THR A  11
 None
 1.04A 6c71B-4zb8A:
undetectable		 6c71B-4zb8A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EID_A_EDTA1111_0
(ARCHAEAL-TYPE OPSIN
2)		 4zb8 PCURE2P6
(Phanerochaete
chrysosporium) 		4 / 4 GLN A 114
ASN A 176
PHE A 189
TYR A 118
 None
 1.42A 6eidA-4zb8A:
0.0		 6eidA-4zb8A:
20.86