SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 8 ILE A 165
MET A  61
VAL A 214
GLY A 245
 None
 0.80A 1dzmA-4zbtA:
undetectable		 1dzmA-4zbtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 4 ILE A 165
MET A  61
VAL A 214
GLY A 245
 None
 0.78A 1e06B-4zbtA:
undetectable		 1e06B-4zbtA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		5 / 9 VAL A  29
GLY A 245
ALA A 163
THR A 242
ILE A 165
 None
 1.34A 1gtnL-4zbtA:
undetectable
1gtnM-4zbtA:
undetectable		 1gtnL-4zbtA:
16.33
1gtnM-4zbtA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		3 / 3 ASP A  64
HIS A 247
ASP A 249
 None
 0.74A 1nw5A-4zbtA:
undetectable		 1nw5A-4zbtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 5 TYR A  67
ALA A  25
TYR A  24
GLN A 118
 None
None
PYR  A 301 ( 4.2A)
PYR  A 301 (-3.0A)
 0.89A 1xl6A-4zbtA:
undetectable
1xl6B-4zbtA:
undetectable		 1xl6A-4zbtA:
23.68
1xl6B-4zbtA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 7 LEU A 234
PHE A  85
ILE A  87
PHE A  33
 None
 0.92A 2opxA-4zbtA:
undetectable		 2opxA-4zbtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		3 / 3 MET A 258
CYH A  93
PRO A 181
 None
 1.05A 3h52C-4zbtA:
undetectable		 3h52C-4zbtA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 7 TYR A  24
LEU A 250
LEU A 209
THR A 255
 PYR  A 301 ( 4.2A)
None
None
None
 0.87A 3lm8A-4zbtA:
undetectable
3lm8C-4zbtA:
undetectable		 3lm8A-4zbtA:
21.40
3lm8C-4zbtA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		5 / 12 PHE A 149
ASP A  64
GLY A 150
PHE A  62
SER A 154
 None
 1.25A 3sueD-4zbtA:
undetectable		 3sueD-4zbtA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 6 PHE A  33
LEU A 234
ALA A  40
THR A  43
 None
 0.94A 3t3zA-4zbtA:
undetectable		 3t3zA-4zbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 6 PHE A  33
LEU A 234
ALA A  40
THR A  43
 None
 0.98A 3t3zB-4zbtA:
undetectable		 3t3zB-4zbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 6 PHE A  33
LEU A 234
ALA A  40
THR A  43
 None
 0.99A 3t3zD-4zbtA:
undetectable		 3t3zD-4zbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		5 / 10 TYR A   4
SER A  69
ARG A 114
ALA A 110
GLY A   3
 None
None
PYR  A 301 (-3.7A)
None
None
 1.40A 4lb9A-4zbtA:
undetectable		 4lb9A-4zbtA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		5 / 12 GLY A  30
GLY A 245
THR A 242
ILE A  63
LEU A 224
 None
 1.18A 5bw4A-4zbtA:
undetectable		 5bw4A-4zbtA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		3 / 3 ASN A 108
ALA A 110
ARG A 114
 None
None
PYR  A 301 (-3.7A)
 0.46A 5cvtB-4zbtA:
undetectable		 5cvtB-4zbtA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		5 / 9 ARG A  57
GLY A 245
ALA A  60
VAL A  31
ILE A 165
 None
 1.16A 5i3cA-4zbtA:
undetectable		 5i3cA-4zbtA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		5 / 12 GLY A  30
GLY A 245
VAL A  28
THR A  27
ALA A 163
 None
 1.14A 5kpcB-4zbtA:
undetectable		 5kpcB-4zbtA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4zbt ACETOACETATE
DECARBOXYLASE
(Streptomyces
bingchenggensis) 		4 / 7 THR A  27
HIS A 247
PHE A 149
THR A 140
 None
 1.36A 5u6mB-4zbtA:
undetectable		 5u6mB-4zbtA:
19.08