SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 11 GLU A  42
HIS A 124
ARG A 144
SER A 139
PHE A 137
 None
 1.48A 1rnrA-4zbzA:
undetectable		 1rnrA-4zbzA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A 119
ILE A  67
ARG A  75
LEU A  63
PHE A 182
 None
 1.24A 2qk8A-4zbzA:
undetectable		 2qk8A-4zbzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A  73
ARG A 186
ILE A  67
 GOL  A 203 ( 4.7A)
None
None
 0.61A 2xn5B-4zbzA:
undetectable		 2xn5B-4zbzA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 5 ARG A  75
PHE A 182
LEU A  63
PHE A  55
 None
 1.26A 3ag3C-4zbzA:
undetectable
3ag3J-4zbzA:
undetectable		 3ag3C-4zbzA:
18.38
3ag3J-4zbzA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  40
GLY A  41
LEU A 121
GLN A 109
ILE A   7
 None
 1.05A 3ijdA-4zbzA:
undetectable		 3ijdA-4zbzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  40
GLY A  41
LEU A 121
GLN A 109
ILE A   7
 None
 1.07A 3ijdB-4zbzA:
undetectable		 3ijdB-4zbzA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 117
LEU A 121
ILE A  67
LEU A  71
ILE A  37
 None
None
None
None
GOL  A 203 (-4.3A)
 1.04A 3tq9A-4zbzA:
undetectable		 3tq9A-4zbzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 108
LYS A   1
LYS A   6
 None
 0.94A 4k50A-4zbzA:
undetectable		 4k50A-4zbzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 108
LYS A   1
LYS A   6
 None
 1.07A 4k50E-4zbzA:
undetectable		 4k50E-4zbzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 108
LYS A   1
LYS A   6
 None
 1.05A 4k50I-4zbzA:
undetectable		 4k50I-4zbzA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A 106
ARG A 108
MET A   1
 None
 0.86A 4m11C-4zbzA:
undetectable		 4m11C-4zbzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 12 ILE A 140
ILE A 110
ASP A 107
ILE A 129
ASN A 136
 MES  A 202 ( 4.2A)
None
None
None
None
 1.12A 4o1eA-4zbzA:
undetectable		 4o1eA-4zbzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A  41
PHE A  55
ASN A  82
HIS A 164
 None
 0.32A 4wryA-4zbzA:
9.8		 4wryA-4zbzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A  41
PHE A  55
ASN A  82
HIS A 164
 None
 0.34A 4wrzA-4zbzA:
10.0		 4wrzA-4zbzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A  41
PHE A  55
ASN A  82
HIS A 164
 None
 0.31A 4ws0A-4zbzA:
9.7		 4ws0A-4zbzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A  41
PHE A  55
ASN A  82
HIS A 164
 None
 0.31A 4ws1A-4zbzA:
9.7		 4ws1A-4zbzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 6 ALA A 166
PRO A 165
PHE A  55
GLU A  48
 None
 0.90A 5odqA-4zbzA:
3.1		 5odqA-4zbzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		4 / 5 ARG A  75
PHE A 182
LEU A  63
PHE A  55
 None
 1.25A 5wauC-4zbzA:
undetectable
5wauJ-4zbzA:
undetectable		 5wauC-4zbzA:
18.38
5wauJ-4zbzA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4zbz URACIL-DNA
GLYCOSYLASE
(Sulfurisphaera
tokodaii) 		5 / 10 LEU A  73
ILE A 117
LEU A 178
LEU A  63
GLU A  74
 GOL  A 203 ( 4.7A)
None
None
None
None
 1.08A 5y7pG-4zbzA:
undetectable		 5y7pG-4zbzA:
21.15