SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 11 ASN A 447
SER A 191
GLY A 192
ASN A 445
GLY A 178
 None
 1.26A 1ho5A-4zc0A:
undetectable		 1ho5A-4zc0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 7 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.76A 1p2yA-4zc0A:
undetectable		 1p2yA-4zc0A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 11 GLU A  95
VAL A  98
ILE A 101
ILE A  85
PHE A  40
 None
 1.24A 2dg3A-4zc0A:
undetectable		 2dg3A-4zc0A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 11 GLU A  95
VAL A  98
ILE A 101
ILE A  85
PHE A  40
 None
 1.26A 2dg4A-4zc0A:
undetectable		 2dg4A-4zc0A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 TYR A 189
VAL A 453
THR A 450
 None
 0.76A 2ygnA-4zc0A:
undetectable		 2ygnA-4zc0A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 LEU A 218
VAL A 227
GLY A 226
LEU A 307
LEU A 275
 None
 1.02A 3ijdA-4zc0A:
undetectable		 3ijdA-4zc0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 LEU A 218
VAL A 227
GLY A 226
LEU A 307
LEU A 275
 None
 1.05A 3ijdB-4zc0A:
undetectable		 3ijdB-4zc0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		5 / 12 ALA A 342
LYS A 339
LEU A 338
ALA A 351
ILE A 312
 None
 1.19A 3ut5D-4zc0A:
2.6		 3ut5D-4zc0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 5 LEU A 359
ARG A 204
PRO A 205
ALA A 203
 None
 1.49A 3vm4A-4zc0A:
undetectable		 3vm4A-4zc0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 7 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.55A 4cp4A-4zc0A:
undetectable		 4cp4A-4zc0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 381
ARG A 336
ASP A 374
 None
 0.79A 4fp9D-4zc0A:
2.5		 4fp9D-4zc0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 381
ARG A 336
ASP A 374
 None
 0.74A 4fzvA-4zc0A:
undetectable		 4fzvA-4zc0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 8 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.60A 4l4bA-4zc0A:
undetectable		 4l4bA-4zc0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 7 HIS A   6
LEU A  10
ALA A 104
HIS A   3
 None
 0.96A 5hrqE-4zc0A:
undetectable
5hrqF-4zc0A:
undetectable
5hrqJ-4zc0A:
undetectable		 5hrqE-4zc0A:
4.21
5hrqF-4zc0A:
5.04
5hrqJ-4zc0A:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 6 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.06A 5igyA-4zc0A:
undetectable		 5igyA-4zc0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 6 ASP A 371
ILE A 441
ARG A 366
TYR A 389
 None
 1.07A 5iwuA-4zc0A:
undetectable		 5iwuA-4zc0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 381
ARG A 336
ASP A 374
 None
 0.59A 5zvgA-4zc0A:
undetectable		 5zvgA-4zc0A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		3 / 3 ASP A 381
ARG A 336
ASP A 374
 None
 0.61A 5zvgB-4zc0A:
undetectable		 5zvgB-4zc0A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4zc0 REPLICATIVE DNA
HELICASE
(Helicobacter
pylori) 		4 / 8 PHE A  40
LEU A  53
ASP A  39
VAL A  98
 None
 0.58A 6cp4A-4zc0A:
undetectable		 6cp4A-4zc0A:
21.19