SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N4H_A_REAA500_1 (NUCLEAR RECEPTOR ROR-BETA)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	5 / 11	ILE A 449 VAL A 307 MET A 309 ARG A 357 VAL A 382	None	1.11A	1n4hA-4zckA: undetectable	1n4hA-4zckA: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q7K_A_TESA304_1 (ANDROGEN RECEPTOR)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	5 / 12	LEU A 335 VAL A 382 MET A 309 MET A 373 LEU A 380	None	1.25A	2q7kA-4zckA: undetectable	2q7kA-4zckA: 19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZT7_A_GLYA1300_0 (GLYCYL-TRNA SYNTHETASE)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	4 / 7	GLU A 570 GLU A 566 ARG A 422 SER A 453	None	1.20A	2zt7A-4zckA: undetectable	2zt7A-4zckA: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A3Y_A_OBNA6000_1 (NA, K-ATPASE ALPHA SUBUNIT)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	5 / 10	GLU A 517 PHE A 318 VAL A 578 ALA A 381 LEU A 592	None	1.35A	3a3yA-4zckA: undetectable	3a3yA-4zckA: 14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K13_C_THHC643_1 (5-METHYLTETRAHYDROFO LATE-HOMOCYSTEINE METHYLTRANSFERASE)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	3 / 3	ASN A 601 ASP A 575 ARG A 507	None	0.63A	3k13C-4zckA: undetectable	3k13C-4zckA: 23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KR3_A_GLYA701_0 (GLYCINE--TRNA LIGASE)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	4 / 6	GLU A 322 GLU A 379 ARG A 586 GLU A 579	None	1.31A	4kr3A-4zckA: undetectable	4kr3A-4zckA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L3G_F_ACTF401_0 (METHYLAMINE DEHYDROGENASE HEAVY CHAIN)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	3 / 3	ARG A 590 LEU A 577 GLU A 576	None	0.76A	4l3gF-4zckA: undetectable	4l3gF-4zckA: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_A_IBPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	5 / 10	VAL A 403 VAL A 415 LEU A 419 GLY A 463 LEU A 405	None	1.02A	4ph9A-4zckA: undetectable	4ph9A-4zckA: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_B_IBPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	5 / 10	VAL A 403 VAL A 415 LEU A 419 GLY A 463 LEU A 405	None	1.02A	4ph9B-4zckA: undetectable	4ph9B-4zckA: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLO_A_GBQA1501_1 (SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR)	4zck	GTP-BINDING PROTEIN TYPA/BIPA (Escherichia coli)	5 / 9	ILE A 572 ILE A 523 GLU A 363 VAL A 578 ILE A 587	None	1.47A	6hloA-4zckA: undetectable	6hloA-4zckA: 20.84

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1N4H_A_REAA500_1","NUCLEAR RECEPTOR ROR-BETA","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",5,"ILE A 449;VAL A 307;MET A 309;ARG A 357;VAL A 382","None","1.11A","1n4hA-4zckA:undetectable","1n4hA-4zckA:22.50"],["2Q7K_A_TESA304_1","ANDROGEN RECEPTOR","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",5,"LEU A 335;VAL A 382;MET A 309;MET A 373;LEU A 380","None","1.25A","2q7kA-4zckA:undetectable","2q7kA-4zckA:19.47"],["2ZT7_A_GLYA1300_0","GLYCYL-TRNA SYNTHETASE","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",4,"GLU A 570;GLU A 566;ARG A 422;SER A 453","None","1.20A","2zt7A-4zckA:undetectable","2zt7A-4zckA:18.25"],["3A3Y_A_OBNA6000_1","NA, K-ATPASE ALPHA SUBUNIT","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",5,"GLU A 517;PHE A 318;VAL A 578;ALA A 381;LEU A 592","None","1.35A","3a3yA-4zckA:undetectable","3a3yA-4zckA:14.43"],["3K13_C_THHC643_1","5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",3,"ASN A 601;ASP A 575;ARG A 507","None","0.63A","3k13C-4zckA:undetectable","3k13C-4zckA:23.30"],["4KR3_A_GLYA701_0","GLYCINE--TRNA LIGASE","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",4,"GLU A 322;GLU A 379;ARG A 586;GLU A 579","None","1.31A","4kr3A-4zckA:undetectable","4kr3A-4zckA:21.59"],["4L3G_F_ACTF401_0","METHYLAMINE DEHYDROGENASE HEAVY CHAIN","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",3,"ARG A 590;LEU A 577;GLU A 576","None","0.76A","4l3gF-4zckA:undetectable","4l3gF-4zckA:21.31"],["4PH9_A_IBPA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",5,"VAL A 403;VAL A 415;LEU A 419;GLY A 463;LEU A 405","None","1.02A","4ph9A-4zckA:undetectable","4ph9A-4zckA:23.66"],["4PH9_B_IBPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",5,"VAL A 403;VAL A 415;LEU A 419;GLY A 463;LEU A 405","None","1.02A","4ph9B-4zckA:undetectable","4ph9B-4zckA:23.66"],["6HLO_A_GBQA1501_1","SUBSTANCE-P RECEPTOR,GLGA GLYCOGEN SYNTHASE,SUBSTANCE-P RECEPTOR","4zck","GTP-BINDING PROTEIN TYPA\/BIPA","Escherichia coli",5,"ILE A 572;ILE A 523;GLU A 363;VAL A 578;ILE A 587","None","1.47A","6hloA-4zckA:undetectable","6hloA-4zckA:20.84"]]