SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 TYR A 626
CYH A 690
ASP A 623
VAL A 653
 CDC  A 801 (-4.3A)
CDC  A 801 ( 4.9A)
CDC  A 801 (-3.5A)
None
 1.14A 1ekjC-4zcsA:
undetectable
1ekjD-4zcsA:
undetectable		 1ekjC-4zcsA:
19.30
1ekjD-4zcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 CYH A 690
ASP A 623
VAL A 653
TYR A 626
 CDC  A 801 ( 4.9A)
CDC  A 801 (-3.5A)
None
CDC  A 801 (-4.3A)
 1.13A 1ekjC-4zcsA:
undetectable
1ekjD-4zcsA:
undetectable		 1ekjC-4zcsA:
19.30
1ekjD-4zcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 4 THR A 676
LEU A 677
VAL A 683
LEU A 649
 None
 1.01A 1fbmB-4zcsA:
undetectable		 1fbmB-4zcsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 LYS A 719
ASP A 623
CYH A 690
 None
CDC  A 801 (-3.5A)
CDC  A 801 ( 4.9A)
 1.48A 2br4F-4zcsA:
undetectable		 2br4F-4zcsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 LEU A 699
VAL A 619
TYR A 621
LEU A 744
 None
 0.89A 3v81C-4zcsA:
undetectable		 3v81C-4zcsA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 LEU A 699
VAL A 619
TYR A 621
LEU A 744
 None
 0.85A 4pwdC-4zcsA:
undetectable		 4pwdC-4zcsA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 8 LEU A 699
VAL A 619
TYR A 621
LEU A 744
 None
 0.89A 4q0bA-4zcsA:
undetectable		 4q0bA-4zcsA:
17.71