SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 402
SER A 352
LEU A 355
GLU A 286
HIS A 343
 None
ZN  A 502 ( 4.2A)
None
EDO  A 505 (-3.2A)
ZN  A 501 (-3.3A)
 1.36A 1kw0A-4zd5A:
undetectable		 1kw0A-4zd5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		5 / 10 ALA A 403
VAL A 353
HIS A 341
HIS A 343
THR A 316
 None
EDO  A 505 (-4.6A)
ZN  A 501 ( 3.2A)
ZN  A 501 (-3.3A)
EDO  A 505 (-4.7A)
 1.17A 1r55A-4zd5A:
undetectable		 1r55A-4zd5A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		3 / 3 HIS A 406
HIS A 404
HIS A 356
 ZN  A 502 (-3.1A)
ZN  A 502 (-3.1A)
ZN  A 502 (-3.2A)
 0.41A 2ozrF-4zd5A:
undetectable		 2ozrF-4zd5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		3 / 3 MET A 373
GLU A 422
ASN A 424
 None
 1.11A 3a27A-4zd5A:
undetectable		 3a27A-4zd5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 402
HIS A 343
GLU A 286
HIS A 341
 None
ZN  A 501 (-3.3A)
EDO  A 505 (-3.2A)
ZN  A 501 ( 3.2A)
 0.83A 4a7bB-4zd5A:
undetectable		 4a7bB-4zd5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY A 390
THR A 393
VAL A 410
HIS A 356
 None
None
None
ZN  A 502 (-3.2A)
 1.03A 5ewuA-4zd5A:
undetectable		 5ewuA-4zd5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 6 GLY A 390
THR A 393
VAL A 410
HIS A 356
 None
None
None
ZN  A 502 (-3.2A)
 1.08A 5ewuB-4zd5A:
undetectable		 5ewuB-4zd5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 4 HIS A 406
CYH A 397
HIS A 356
HIS A 404
 ZN  A 502 (-3.1A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.1A)
 1.33A 5zrdA-4zd5A:
undetectable		 5zrdA-4zd5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 381
ILE A 371
ASP A 354
HIS A 358
 None
None
ZN  A 501 ( 2.0A)
None
 0.93A 6ag0A-4zd5A:
undetectable		 6ag0A-4zd5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 381
ILE A 371
ASP A 354
HIS A 358
 None
None
ZN  A 501 ( 2.0A)
None
 0.98A 6ag0C-4zd5A:
undetectable		 6ag0C-4zd5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4zd5 AMSH-LIKE PROTEASE
SST2
(Schizosaccharomy
ces
pombe) 		4 / 8 GLN A 416
VAL A 414
ILE A 369
TYR A 411
 None
EDO  A 504 (-3.7A)
None
None
 0.96A 6cduG-4zd5A:
undetectable
6cduH-4zd5A:
undetectable		 6cduG-4zd5A:
19.27
6cduH-4zd5A:
19.27