SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zd6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 12 ILE A  58
LEU A  12
ALA A 200
ASP A 199
VAL A 114
 None
 1.16A 2yvlD-4zd6A:
4.8		 2yvlD-4zd6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		3 / 3 TYR A  19
ASP A 199
HIS A 162
 None
 0.92A 3e23A-4zd6A:
4.1		 3e23A-4zd6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 8 ILE A  58
ALA A  63
THR A  14
VAL A  52
 None
 0.87A 3me6B-4zd6A:
undetectable		 3me6B-4zd6A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 12 GLN A 138
PHE A 158
GLY A 117
ASP A 199
ALA A 203
 None
 1.12A 3sudB-4zd6A:
undetectable		 3sudB-4zd6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 12 ALA A  69
PHE A  71
ASP A 199
ILE A 159
ARG A 135
 None
 1.39A 3welA-4zd6A:
undetectable		 3welA-4zd6A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 11 ALA A  63
LEU A  94
PHE A  65
PHE A 105
ILE A  58
 None
 1.46A 4claA-4zd6A:
undetectable		 4claA-4zd6A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		3 / 3 TYR A  19
PHE A 158
ARG A 135
 None
 1.00A 4g19D-4zd6A:
undetectable		 4g19D-4zd6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 12 ARG A 174
TRP A 171
GLU A 168
ALA A 128
TYR A  19
 None
 1.28A 4mx0A-4zd6A:
undetectable		 4mx0A-4zd6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		3 / 3 ASP A  41
ARG A  96
PRO A  93
 None
 0.91A 4wanC-4zd6A:
undetectable		 4wanC-4zd6A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 7 ARG A 135
PHE A 170
TYR A  19
TYR A 131
 None
CL  A 301 (-4.8A)
None
None
 1.40A 5a06A-4zd6A:
6.2		 5a06A-4zd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 7 ARG A 135
PHE A 170
TYR A  19
TYR A 131
 None
CL  A 301 (-4.8A)
None
None
 1.41A 5a06C-4zd6A:
4.4		 5a06C-4zd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 7 ARG A 135
PHE A 170
TYR A  19
TYR A 131
 None
CL  A 301 (-4.8A)
None
None
 1.41A 5a06D-4zd6A:
6.4		 5a06D-4zd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 7 ARG A 135
PHE A 170
TYR A  19
TYR A 131
 None
CL  A 301 (-4.8A)
None
None
 1.40A 5a06E-4zd6A:
6.2		 5a06E-4zd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 7 ARG A 135
PHE A 170
TYR A  19
TYR A 131
 None
CL  A 301 (-4.8A)
None
None
 1.41A 5a06F-4zd6A:
6.4		 5a06F-4zd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 5 VAL A  51
THR A  14
ASN A  15
LEU A  42
 None
 1.23A 5m0iB-4zd6A:
undetectable		 5m0iB-4zd6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 12 SER A 118
VAL A 188
GLY A 223
PHE A 170
GLU A 179
 None
None
None
CL  A 301 (-4.8A)
None
 1.09A 6bqgA-4zd6A:
undetectable		 6bqgA-4zd6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 5 TYR A 116
GLN A 161
ASN A 166
THR A 164
 None
CL  A 301 (-4.3A)
CL  A 301 (-3.8A)
CL  A 301 (-4.5A)
 1.43A 6d8pA-4zd6A:
4.4		 6d8pA-4zd6A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		5 / 12 ILE A  90
PHE A 158
VAL A 115
LEU A  82
ALA A 130
 None
 1.16A 6djzA-4zd6A:
undetectable		 6djzA-4zd6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4zd6 HALOHYDRIN EPOXIDASE
B
(Corynebacterium
sp.) 		4 / 8 HIS A 162
ARG A 186
ASP A 183
GLU A 179
 None
 1.17A 6mn4B-4zd6A:
undetectable		 6mn4B-4zd6A:
19.62