SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zdk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 376
GLY A 374
CYH A 398
LEU A 394
ASP A 343
 None
None
None
ONL  A 601 ( 4.1A)
None
 1.46A 1dgmA-4zdkA:
undetectable		 1dgmA-4zdkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 PRO A 525
PRO A 364
GLY A 365
PHE A 538
THR A 521
 None
None
ONL  A 601 (-3.3A)
None
None
 1.44A 1h4oA-4zdkA:
undetectable
1h4oB-4zdkA:
undetectable		 1h4oA-4zdkA:
14.12
1h4oB-4zdkA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_D_BEZD1162_0
(PEROXIREDOXIN 5)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 PRO A 364
GLY A 365
LEU A 537
PHE A 538
THR A 521
 None
ONL  A 601 (-3.3A)
None
None
None
 1.44A 1h4oD-4zdkA:
undetectable		 1h4oD-4zdkA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HD2_A_BEZA201_0
(PEROXIREDOXIN 5
RESIDUES 54-214)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 PRO A 364
GLY A 365
LEU A 537
PHE A 538
THR A 521
 None
ONL  A 601 (-3.3A)
None
None
None
 1.45A 1hd2A-4zdkA:
undetectable		 1hd2A-4zdkA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 380
GLY A 344
VAL A 307
ALA A 305
THR A 348
 None
 1.19A 1jipA-4zdkA:
undetectable		 1jipA-4zdkA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 401
ALA A 404
VAL A 425
VAL A 508
LEU A 394
 None
None
None
None
ONL  A 601 ( 4.1A)
 1.07A 1n4hA-4zdkA:
undetectable		 1n4hA-4zdkA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 495
SER A 496
LEU A 396
VAL A 505
ALA A 403
 None
 1.17A 1q23H-4zdkA:
undetectable
1q23I-4zdkA:
undetectable		 1q23H-4zdkA:
15.53
1q23I-4zdkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 399
PRO A 525
VAL A 320
LEU A 355
ALA A 382
 None
 1.16A 1rv7A-4zdkA:
undetectable
1rv7B-4zdkA:
undetectable		 1rv7A-4zdkA:
10.75
1rv7B-4zdkA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 268
PHE A 271
ALA A 270
LEU A  31
 None
 0.79A 1ukbA-4zdkA:
4.1		 1ukbA-4zdkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 PRO A 525
PRO A 364
GLY A 365
PHE A 538
THR A 521
 None
None
ONL  A 601 (-3.3A)
None
None
 1.48A 1urmA-4zdkA:
undetectable		 1urmA-4zdkA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 397
HIS A 476
ARG A 477
 ONL  A 601 (-3.0A)
ONL  A 601 (-4.9A)
None
 0.70A 1zlqA-4zdkA:
undetectable		 1zlqA-4zdkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 390
GLY A 543
ALA A 544
ASP A 547
VAL A 519
 None
 0.83A 2ieoA-4zdkA:
undetectable		 2ieoA-4zdkA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 THR A 151
VAL A 181
VAL A 148
ILE A 150
VAL A 149
 None
 1.48A 2qboA-4zdkA:
undetectable		 2qboA-4zdkA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 362
PRO A 364
LEU A 306
ARG A 325
 None
 1.23A 2qd2A-4zdkA:
4.7		 2qd2A-4zdkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 364
GLY A 308
TYR A 317
 None
 0.71A 2vouA-4zdkA:
undetectable		 2vouA-4zdkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 364
GLY A 308
TYR A 317
 None
 0.56A 2vouB-4zdkA:
undetectable		 2vouB-4zdkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 364
GLY A 308
TYR A 317
 None
 0.58A 2vouC-4zdkA:
undetectable		 2vouC-4zdkA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 263
LEU A  26
GLY A  25
MET A  44
ARG A  84
 None
ACP  A 602 (-4.0A)
ACP  A 602 ( 3.1A)
None
None
 1.48A 2yhdA-4zdkA:
undetectable		 2yhdA-4zdkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  70
SER A 450
HIS A 535
ARG A 530
 None
 1.12A 3b9lA-4zdkA:
2.2		 3b9lA-4zdkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 SER A 529
SER A 319
GLU A  65
ASP A 315
 None
None
None
ACP  A 602 ( 4.9A)
 1.32A 3bc9A-4zdkA:
undetectable		 3bc9A-4zdkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 362
PRO A 364
LEU A 306
ARG A 325
 None
 1.27A 3hcoA-4zdkA:
4.2		 3hcoA-4zdkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 362
PRO A 364
LEU A 306
ARG A 325
 None
 1.32A 3hcoB-4zdkA:
3.3		 3hcoB-4zdkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 377
ASN A 413
GLY A 371
SER A 342
ILE A 372
 None
 1.24A 3k13B-4zdkA:
undetectable		 3k13B-4zdkA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 VAL A 101
PHE A 165
PHE A  13
VAL A 172
 None
 1.36A 3rv5C-4zdkA:
undetectable
3rv5D-4zdkA:
undetectable		 3rv5C-4zdkA:
9.25
3rv5D-4zdkA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 295
PHE A 329
PHE A  85
ILE A 256
LEU A 291
 None
None
None
ACP  A 602 (-4.7A)
None
 1.13A 3t3rA-4zdkA:
undetectable		 3t3rA-4zdkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 272
LEU A 276
LEU A 278
ILE A 150
 None
 0.89A 3u5kA-4zdkA:
undetectable		 3u5kA-4zdkA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 272
LEU A 276
LEU A 278
ILE A 150
 None
 0.91A 4a9jC-4zdkA:
undetectable		 4a9jC-4zdkA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A 488
LEU A 394
ILE A 399
CYH A 398
 None
ONL  A 601 ( 4.1A)
None
None
 0.79A 4asdA-4zdkA:
undetectable		 4asdA-4zdkA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 183
ILE A 213
ALA A 169
ALA A 168
ILE A 122
 None
 1.07A 4h1nA-4zdkA:
undetectable		 4h1nA-4zdkA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 518
ARG A 383
GLU A 402
LEU A 493
 None
 1.35A 4hojA-4zdkA:
undetectable		 4hojA-4zdkA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 365
GLY A 366
LEU A 394
HIS A 476
HIS A 524
 ONL  A 601 (-3.3A)
ONL  A 601 (-3.7A)
ONL  A 601 ( 4.1A)
ONL  A 601 (-4.9A)
ONL  A 601 ( 4.8A)
 0.38A 4l8fB-4zdkA:
19.0		 4l8fB-4zdkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 365
GLY A 366
LEU A 394
HIS A 476
HIS A 524
 ONL  A 601 (-3.3A)
ONL  A 601 (-3.7A)
ONL  A 601 ( 4.1A)
ONL  A 601 (-4.9A)
ONL  A 601 ( 4.8A)
 0.42A 4l8fD-4zdkA:
18.9		 4l8fD-4zdkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 11 LEU A  47
ALA A 168
ASP A 127
ILE A 122
ILE A 213
ILE A 129
 None
 1.48A 4njtC-4zdkA:
undetectable		 4njtC-4zdkA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 340
SER A 342
GLY A 350
ALA A 351
LEU A 355
 None
 0.89A 4rrwD-4zdkA:
undetectable		 4rrwD-4zdkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 340
SER A 342
GLY A 350
ALA A 351
LEU A 355
 None
 0.89A 4rrzD-4zdkA:
undetectable		 4rrzD-4zdkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 VAL A 340
SER A 342
GLY A 350
ALA A 351
LEU A 355
 None
 0.75A 4rs0A-4zdkA:
undetectable		 4rs0A-4zdkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 169
GLY A 154
GLN A 163
GLY A 158
LEU A 210
 None
 1.11A 4uilH-4zdkA:
undetectable
4uilL-4zdkA:
undetectable		 4uilH-4zdkA:
15.73
4uilL-4zdkA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 THR A 521
LEU A 392
HIS A 524
GLY A 395
 None
None
ONL  A 601 ( 4.8A)
None
 1.13A 5gwyA-4zdkA:
undetectable		 5gwyA-4zdkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 507
LEU A 455
ALA A 453
SER A 450
LEU A 392
 None
 1.16A 5h8tA-4zdkA:
undetectable		 5h8tA-4zdkA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 128
HIS A 124
VAL A 105
 None
 0.60A 5trqB-4zdkA:
undetectable		 5trqB-4zdkA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4zdk CTP SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 263
ILE A 150
PHE A 183
ALA A 219
 None
 0.83A 5y7pC-4zdkA:
undetectable		 5y7pC-4zdkA:
21.18