SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zdl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 ASP A 201
GLU A 211
TYR A 245
 None
 0.79A 1wsvA-4zdlA:
undetectable		 1wsvA-4zdlA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 5 LEU A  55
SER A 328
LEU A 121
LEU A 320
 None
 0.95A 1yajD-4zdlA:
3.5		 1yajD-4zdlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 5 ILE A 166
ILE A 275
ILE A 241
LEU A 148
 None
 0.84A 1zgyA-4zdlA:
undetectable		 1zgyA-4zdlA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 7 THR A 144
VAL A 257
GLY A 256
ASP A 283
 PLR  A1001 (-3.6A)
None
None
None
 0.87A 2a1mA-4zdlA:
undetectable		 2a1mA-4zdlA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 282
PHE A 286
VAL A 257
MET A 263
ALA A 129
 None
 1.36A 2jj8B-4zdlA:
undetectable		 2jj8B-4zdlA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 9 GLY A  45
LEU A 329
TYR A 334
LEU A 128
LEU A  35
 None
 1.09A 2npnA-4zdlA:
3.0		 2npnA-4zdlA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 GLU A 194
HIS A 368
GLU A 197
 None
 0.79A 2x45B-4zdlA:
undetectable		 2x45B-4zdlA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 GLU A 194
HIS A 368
GLU A 197
 None
 0.87A 2x45C-4zdlA:
undetectable		 2x45C-4zdlA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 234
GLU A 237
SER A 259
 None
 0.90A 2xctD-4zdlA:
3.4		 2xctD-4zdlA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 11 ASP A  62
GLY A 110
GLY A  96
ILE A  95
ILE A  92
 None
 0.85A 3ebzB-4zdlA:
undetectable		 3ebzB-4zdlA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 8 ARG A  90
ALA A  59
ILE A  60
ASN A  65
 None
 1.00A 3fxrA-4zdlA:
undetectable		 3fxrA-4zdlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 ASP A  62
ASN A  64
SER A 112
 None
 0.85A 3lslA-4zdlA:
undetectable
3lslD-4zdlA:
undetectable		 3lslA-4zdlA:
20.99
3lslD-4zdlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 112
ASP A  62
ASN A  64
 None
 0.81A 3lslA-4zdlA:
undetectable
3lslD-4zdlA:
undetectable		 3lslA-4zdlA:
20.99
3lslD-4zdlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A 408
ARG A 362
ASN A 435
 None
 0.66A 3qxvD-4zdlA:
undetectable		 3qxvD-4zdlA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 11 ASP A  62
GLY A 110
GLY A  96
ILE A  95
ILE A  92
 None
 0.88A 3s45B-4zdlA:
undetectable		 3s45B-4zdlA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 4 SER A 174
ASP A 283
ASP A 321
ALA A 143
 PLR  A1001 (-2.7A)
None
None
PLR  A1001 (-3.0A)
 1.32A 3uj6A-4zdlA:
3.4		 3uj6A-4zdlA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 454
LEU A 395
GLU A 361
LEU A 434
ALA A 387
 None
 1.18A 4wg0B-4zdlA:
undetectable
4wg0C-4zdlA:
undetectable
4wg0D-4zdlA:
undetectable		 4wg0B-4zdlA:
4.32
4wg0C-4zdlA:
4.32
4wg0D-4zdlA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 454
LEU A 395
GLU A 361
LEU A 434
ALA A 387
 None
 1.16A 4wg0D-4zdlA:
undetectable
4wg0E-4zdlA:
undetectable
4wg0F-4zdlA:
undetectable		 4wg0D-4zdlA:
4.32
4wg0E-4zdlA:
4.32
4wg0F-4zdlA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 11 LEU A 454
LEU A 395
GLU A 361
LEU A 434
ALA A 387
 None
 1.12A 4wg0F-4zdlA:
undetectable
4wg0G-4zdlA:
undetectable
4wg0H-4zdlA:
undetectable		 4wg0F-4zdlA:
4.32
4wg0G-4zdlA:
4.32
4wg0H-4zdlA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 11 ALA A 387
GLU A 361
LEU A 434
LEU A 454
LEU A 395
 None
 1.16A 4wg0G-4zdlA:
undetectable
4wg0H-4zdlA:
undetectable
4wg0I-4zdlA:
undetectable		 4wg0G-4zdlA:
4.32
4wg0H-4zdlA:
4.32
4wg0I-4zdlA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 VAL A 406
PHE A 422
ARG A 169
 None
 0.95A 4xr4B-4zdlA:
3.5		 4xr4B-4zdlA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 6 ASP A 171
PRO A 430
TYR A 433
LEU A 364
 None
 1.08A 5bmvB-4zdlA:
undetectable		 5bmvB-4zdlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 283
PRO A 289
GLY A 292
THR A 144
SER A 317
 None
None
None
PLR  A1001 (-3.6A)
None
 1.28A 5hfjA-4zdlA:
3.2		 5hfjA-4zdlA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		3 / 3 CYH A 262
LYS A 261
HIS A 264
 None
 1.00A 5js5A-4zdlA:
undetectable		 5js5A-4zdlA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens) 		4 / 7 THR A 154
PHE A 152
LEU A 148
SER A 222
 None
 1.10A 5uxcA-4zdlA:
undetectable		 5uxcA-4zdlA:
19.65