SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zdm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 12 ARG A 147
ILE A  91
VAL A  93
GLU A  17
ASP A 190
 GLY  A 301 (-3.2A)
None
None
GLY  A 301 ( 4.6A)
None
 1.36A 2qeoA-4zdmA:
undetectable		 2qeoA-4zdmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 12 ALA A 154
SER A 155
LEU A 217
ASP A 190
TYR A 174
 None
 1.15A 3k2hA-4zdmA:
undetectable		 3k2hA-4zdmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 12 ALA A 154
SER A 155
LEU A 217
ASP A 190
TYR A 174
 None
 1.16A 3k2hB-4zdmA:
undetectable		 3k2hB-4zdmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 9 ASN A  77
GLY A  67
GLY A  68
GLY A  78
ASP A  63
 None
 1.06A 3ztvA-4zdmA:
undetectable		 3ztvA-4zdmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 9 ASN A  77
GLY A  67
GLY A  68
GLY A  78
ASP A  63
 None
 1.11A 4h2fA-4zdmA:
undetectable		 4h2fA-4zdmA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 9 ASN A  77
GLY A  67
GLY A  68
GLY A  78
ASP A  63
 None
 1.13A 4h2gA-4zdmA:
undetectable		 4h2gA-4zdmA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 5 SER A 225
ARG A 222
LEU A 221
ASP A 106
 None
 1.39A 4xdtA-4zdmA:
undetectable		 4xdtA-4zdmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 4 VAL A 120
VAL A 187
TYR A 139
GLN A 140
 None
 0.97A 5qggA-4zdmA:
undetectable		 5qggA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		3 / 3 VAL A 187
TYR A 139
GLN A 140
 None
 0.69A 5qgkA-4zdmA:
undetectable		 5qgkA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 4 VAL A 120
VAL A 187
TYR A 139
GLN A 140
 None
 0.94A 5qgoA-4zdmA:
undetectable		 5qgoA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 4 VAL A 120
VAL A 187
TYR A 139
GLN A 140
 None
 0.94A 5qgpA-4zdmA:
undetectable		 5qgpA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 4 VAL A 120
VAL A 187
TYR A 139
GLN A 140
 None
 0.93A 5qgqA-4zdmA:
undetectable		 5qgqA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		3 / 3 VAL A 187
TYR A 139
GLN A 140
 None
 0.68A 5qgrA-4zdmA:
undetectable		 5qgrA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		3 / 3 VAL A 187
TYR A 139
GLN A 140
 None
 0.71A 5qgtA-4zdmA:
undetectable		 5qgtA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 4 VAL A 120
VAL A 187
TYR A 139
GLN A 140
 None
 0.94A 5qhbA-4zdmA:
undetectable		 5qhbA-4zdmA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		4 / 4 ASP A  63
ILE A  15
PRO A  16
LEU A  64
 None
 1.49A 6mkeB-4zdmA:
undetectable		 6mkeB-4zdmA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		3 / 3 ARG A 101
PHE A 219
PHE A  66
 GLY  A 301 (-2.9A)
None
GLY  A 301 (-3.1A)
 1.04A 6nknC-4zdmA:
undetectable
6nknJ-4zdmA:
undetectable		 6nknC-4zdmA:
24.36
6nknJ-4zdmA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4zdm GLUTAMATE RECEPTOR
KAINATE-LIKE PROTEIN
(Pleurobrachia
bachei) 		5 / 10 THR A 199
GLY A 177
GLY A 175
GLU A 176
PHE A 186
 None
 1.42A 6nqaK-4zdmA:
undetectable		 6nqaK-4zdmA:
20.14