SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4zdt STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
(Schizosaccharomy
ces
pombe) 		5 / 12 ASN A 205
LEU A 207
ALA A 194
CYH A 228
THR A 229
 None
None
None
ZN  A 302 (-2.3A)
None
 1.17A 2aa5B-4zdtA:
undetectable		 2aa5B-4zdtA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4zdt STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX4
(Schizosaccharomy
ces
pombe) 		4 / 6 ILE B 376
CYH B 407
TRP B 406
LEU B 391
 None
 0.77A 2q83B-4zdtB:
undetectable		 2q83B-4zdtB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4zdt STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 214
PHE A 240
ALA A 194
LEU A 182
 None
 0.86A 4ejgB-4zdtA:
undetectable		 4ejgB-4zdtA:
10.62