SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ze8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		5 / 11 ASP A  96
ARG A  94
ILE A 171
THR A 161
ARG A 101
 None
 1.42A 2f9wA-4ze8A:
undetectable
2f9wB-4ze8A:
undetectable		 2f9wA-4ze8A:
18.66
2f9wB-4ze8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 7 TRP A 423
GLU A  47
GLY A 142
PHE A 174
 None
 0.95A 2qmzA-4ze8A:
undetectable
2qmzB-4ze8A:
2.1		 2qmzA-4ze8A:
19.87
2qmzB-4ze8A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 ILE A 488
GLY A 329
ARG A 477
PHE A 332
 None
 0.80A 2vctA-4ze8A:
undetectable		 2vctA-4ze8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 ILE A 488
GLY A 329
ARG A 477
PHE A 332
 None
 0.76A 2vctB-4ze8A:
undetectable		 2vctB-4ze8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 ILE A 488
GLY A 329
ARG A 477
PHE A 332
 None
 0.81A 2vctC-4ze8A:
undetectable		 2vctC-4ze8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 7 ILE A 488
GLY A 329
ARG A 477
PHE A 332
 None
 0.78A 2vctD-4ze8A:
undetectable		 2vctD-4ze8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		5 / 11 LEU A 250
GLY A  38
VAL A 240
ILE A 269
ALA A 497
 None
 0.98A 2yy8A-4ze8A:
undetectable
2yy8B-4ze8A:
undetectable		 2yy8A-4ze8A:
20.56
2yy8B-4ze8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		5 / 12 GLU A 172
ILE A 171
SER A 168
PRO A 152
ILE A  95
 None
 1.12A 3cd2A-4ze8A:
undetectable		 3cd2A-4ze8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 4 PRO A 230
TYR A 206
GLY A 204
THR A 203
 None
 0.90A 3ib0A-4ze8A:
2.5		 3ib0A-4ze8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 5 ALA A 497
ALA A 498
ARG A 278
LYS A 505
 None
 1.09A 3kp2B-4ze8A:
undetectable		 3kp2B-4ze8A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		3 / 3 GLU A 510
PHE A 509
GLN A 422
 None
EDO  A 607 (-3.6A)
None
 1.02A 3r55A-4ze8A:
undetectable		 3r55A-4ze8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 ARG A  32
LEU A 518
ASP A 256
ILE A 257
 SO4  A 601 (-4.1A)
None
None
None
 1.08A 4l7iA-4ze8A:
undetectable		 4l7iA-4ze8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 7 ARG A 416
ILE A 367
PHE A 297
LEU A 306
 GOL  A 606 (-3.6A)
None
None
None
 1.08A 4mmcA-4ze8A:
undetectable		 4mmcA-4ze8A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		5 / 12 LEU A 518
ASN A 517
GLN A  62
LEU A  37
PHE A  73
 None
 1.24A 4p6xE-4ze8A:
undetectable		 4p6xE-4ze8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		3 / 3 ASP A 265
ARG A 246
PRO A 243
 None
 0.83A 4wanC-4ze8A:
undetectable		 4wanC-4ze8A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		3 / 3 TYR A 145
TYR A 375
SER A 419
 None
 0.99A 5iktB-4ze8A:
undetectable		 5iktB-4ze8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 GLU A 513
GLY A 204
PRO A 205
ASP A  65
 PEG  A 605 ( 4.1A)
None
None
None
 0.92A 5kgpA-4ze8A:
undetectable		 5kgpA-4ze8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 GLU A 513
GLY A 204
PRO A 205
ASP A  65
 PEG  A 605 ( 4.1A)
None
None
None
 0.92A 5kgpB-4ze8A:
undetectable		 5kgpB-4ze8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 TYR A 255
TYR A 237
THR A 236
ILE A 235
 None
 0.78A 5mzrE-4ze8A:
undetectable		 5mzrE-4ze8A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		5 / 12 TYR A 225
PRO A 228
GLY A 227
LEU A  84
ASP A  65
 None
 1.36A 5yn6A-4ze8A:
undetectable		 5yn6A-4ze8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		4 / 8 GLU A 513
ARG A 181
PRO A 205
ILE A 235
 PEG  A 605 ( 4.1A)
EDO  A 607 ( 4.1A)
None
None
 1.12A 6a4iA-4ze8A:
undetectable		 6a4iA-4ze8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)
(Agrobacterium
fabrum) 		3 / 3 TRP A 447
ILE A 479
GLU A 455
 None
 0.81A 6hcxA-4ze8A:
undetectable		 6hcxA-4ze8A:
11.09