SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		5 / 12 VAL A 480
ASP A 482
ASP A 286
THR A 399
GLY A 424
 None
 1.47A 1ia0B-4zefA:
undetectable		 1ia0B-4zefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		5 / 12 VAL A 480
ASP A 482
ASP A 286
THR A 399
GLY A 424
 None
 1.47A 1tubB-4zefA:
undetectable		 1tubB-4zefA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		4 / 6 THR A 328
ARG A 333
ASP A 416
THR A 399
 GLN  A 501 (-4.1A)
GLN  A 501 (-2.9A)
GLN  A 501 ( 4.9A)
None
 1.15A 2okcB-4zefA:
undetectable		 2okcB-4zefA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		5 / 10 TYR A 343
ILE A 475
ILE A 285
GLY A 326
LEU A 463
 None
 1.12A 3elzB-4zefA:
undetectable		 3elzB-4zefA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		5 / 10 TYR A 343
ILE A 475
ILE A 285
GLY A 326
LEU A 463
 None
 1.25A 3em0A-4zefA:
undetectable		 3em0A-4zefA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		4 / 5 THR A 478
ILE A 475
LYS A 474
GLU A 471
 None
 1.43A 4ac9C-4zefA:
undetectable		 4ac9C-4zefA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		4 / 5 THR A 478
ILE A 475
LYS A 474
GLU A 471
 None
 1.43A 4acaC-4zefA:
undetectable		 4acaC-4zefA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		4 / 5 THR A 478
ILE A 475
LYS A 474
GLU A 471
 None
 1.36A 4acbC-4zefA:
undetectable		 4acbC-4zefA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		4 / 5 TYR A 391
VAL A 370
ASP A 412
ALA A 413
 None
 1.05A 5otrA-4zefA:
undetectable		 5otrA-4zefA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4zef AMINO ACID ABC
TRANSPORTER AMINO
ACID-BINDING/PERMEAS
E
(Enterococcus
faecalis) 		4 / 6 ILE A 475
GLY A 470
TYR A 472
GLU A 471
 None
 1.11A 6gqiA-4zefA:
undetectable		 6gqiA-4zefA:
18.81