SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4zel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 TRP A 104
ARG A  79
THR A 105
 None
 0.89A 1df7A-4zelA:
undetectable		 1df7A-4zelA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 GLN A 410
TYR A 249
ARG A 350
 None
 0.87A 1gtbA-4zelA:
undetectable		 1gtbA-4zelA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 12 SER A  58
GLY A  84
LEU A  76
ILE A 172
LEU A  59
 None
 1.34A 1lhuA-4zelA:
undetectable		 1lhuA-4zelA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ASN A  97
ASP A 158
GLN A 128
 None
 0.82A 3eeyC-4zelA:
undetectable		 3eeyC-4zelA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ASN A  97
ASP A 158
GLN A 128
 None
 0.83A 3eeyD-4zelA:
undetectable		 3eeyD-4zelA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ASN A  97
ASP A 158
GLN A 128
 None
 0.80A 3eeyE-4zelA:
undetectable		 3eeyE-4zelA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 HIS A 412
HIS A 414
MET A 487
 CU  A 701 (-3.3A)
CU  A 701 (-4.2A)
CU  A 701 (-2.7A)
 0.38A 3mihA-4zelA:
24.9		 3mihA-4zelA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 ASN A 361
ALA A 318
ARG A 243
 None
 0.80A 3tj7C-4zelA:
undetectable
3tj7D-4zelA:
1.3		 3tj7C-4zelA:
16.02
3tj7D-4zelA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		3 / 3 TYR A 440
ARG A 194
HIS A 443
 None
 1.12A 4fubA-4zelA:
undetectable		 4fubA-4zelA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 12 PHE A  74
LEU A 145
VAL A 101
ASP A 130
MET A  89
 None
 1.43A 4mubA-4zelA:
undetectable		 4mubA-4zelA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 6 GLN A  75
PHE A  74
PHE A  87
LEU A  53
 None
 1.10A 5b1bC-4zelA:
undetectable
5b1bJ-4zelA:
undetectable		 5b1bC-4zelA:
17.32
5b1bJ-4zelA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 6 GLY A 417
THR A 477
GLU A 486
ARG A 194
 None
 1.10A 5btaA-4zelA:
undetectable
5btaB-4zelA:
undetectable
5btaC-4zelA:
undetectable		 5btaA-4zelA:
22.04
5btaB-4zelA:
17.54
5btaC-4zelA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 6 ARG A 194
GLY A 417
THR A 477
GLU A 486
 None
 1.08A 5btcA-4zelA:
undetectable
5btcC-4zelA:
undetectable
5btcD-4zelA:
undetectable		 5btcA-4zelA:
22.04
5btcC-4zelA:
22.04
5btcD-4zelA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 6 GLY A 417
THR A 477
GLU A 486
ARG A 194
 None
 1.10A 5btcA-4zelA:
undetectable
5btcB-4zelA:
undetectable
5btcC-4zelA:
undetectable		 5btcA-4zelA:
22.04
5btcB-4zelA:
17.54
5btcC-4zelA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 7 ARG A 194
GLY A 417
THR A 477
GLU A 486
 None
 1.12A 5btfA-4zelA:
undetectable
5btfC-4zelA:
undetectable
5btfD-4zelA:
undetectable		 5btfA-4zelA:
22.04
5btfC-4zelA:
22.04
5btfD-4zelA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 5 THR A 254
GLY A 256
HIS A 262
ASP A 345
 None
 1.17A 5c0oH-4zelA:
undetectable		 5c0oH-4zelA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		5 / 11 VAL A 507
ILE A 561
TYR A 389
ILE A 463
ILE A 377
 None
 1.16A 5hw8A-4zelA:
undetectable
5hw8D-4zelA:
undetectable		 5hw8A-4zelA:
12.75
5hw8D-4zelA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens) 		4 / 5 LEU A  76
PHE A  74
PHE A  87
LEU A  53
 None
 1.09A 5x1bP-4zelA:
undetectable		 5x1bP-4zelA:
17.32